Synthesis of sulfonyl flosulide

Synthesis

Volumn , Issue 8, 1998, Pages 1101-1103

  Black, W Cameron ^a   Guay, Benoit ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

Benzothiophene; COX 2 inhibitor; Flosulide

Indexed keywords

BENZOTHIOPHENE; CYCLOOXYGENASE 2 INHIBITOR; FLOSULIDE; SULFONE DERIVATIVE;

CONJUGATE; CONTROLLED STUDY; DRUG SYNTHESIS; NONHUMAN; SHORT SURVEY; STRUCTURE ACTIVITY RELATION;

EID: 0031822821     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1998-2114     Document Type: Short Survey

References (15)

1. (a) Hla, T.; Neilson, K. Proc. Natl. Acad. Sci. USA 1992, 89, 7384.
2. (b) Holtzman, M.J.; Turk, J.; Shornick, L.P. J. Biol. Chem. 1992, 267, 21438.
3. Herschman, H.R. Cancer and Metastasis Reviews 1994, 13, 241.
4. Kennedy, B.P.; Chan, C.-C.; Culp, S.A.; Cromlish, W.A. Biochem. Biophys. Res. Commun. 1993, 197, 494.
5. (a) Graul, A.; Martel, A.M.; Castaner, J. Drugs of the Future 1997, 22, 711.
6. (b) Lanza, F.; Simon, T.; Quan, H.; Bolognese, J.; Rack, M.F.; Hoover, M.; Wilson, F. Meeting of the American Gastroenterological Association, Washington D.C., May 1997; Abstract 395.
7. Wiesenberg-Böttcher, I.; Schweizer, A.; Green, J.R.; Seltenmeyer, Y.; Müller, K. Agents Actions 1989, 26, 240.
8. Li, C.-S.; Black, W.C.; Chan, C.-C.; Ford-Hutchinson, A.W.; Gauthier, J.Y.; Gordon, R.; Guay, D.; Kargman, S.; Lau, C.K.; Mancini, J.; Ouimet, N.; Roy, P.; Vickers, P.; Wong, E.; Young, R.N.; Zamboni, R.; Prasit, P. J. Med. Chem. 1995, 38, 4897.
9. Haché, B.; Gareau, Y. Tetrahedron Lett. 1994, 35, 1837.
10. Stille, J.K. Angew. Chem. 1986, 98, 504;
11. Angew. Chem. Int. Ed. Engl. 1986, 25, 508.
12. (a) Blacklock, T.J.; Butcher, J.W.; Sohar, P.; Lamanec, T.R.; Grabowski, E.J.J. J.Org. Chem. 1989, 54, 3907.
13. (b) Schultz, H.S.; Freyermuth, H.B.; Bue, S.R. J. Org. Chem. 1963, 28, 1140.
14. Chan, C.-C.; Boyce, S.; Brideau, C.; Ford-Hutchinson, A.W.; Gordon, R.; Guay, D.; Hill, R.G.; Li, C.-S.; Mancini, J.; Penneton, M.; Prasit, P.; Rasori, R.; Riendeau, D.; Roy, P.; Vickers, P.; Wong, E.; Rodger, I.W. J. Pharmacol. Exp. Ther. 1995, 274, 1531.
15. Brideau, C.; Kargman, S.; Liu, S.; Dallob, A.L.; Ehrich, E.W.; Rodger, I.W.; Chan, C.-C. Inflamm. Res. 1996, 45, 68.