Membrane fouling in sterile filtration of recombinant human growth hormone

Biotechnology and Bioengineering

Volumn 50, Issue 3, 1996, Pages 319-328

  Maa, Yuh Fun ^a   Hsu, Chung C ^a  

^a GENENTECH INC   (United States)

Author keywords

membrane fouling; microfiltration; protein aggregation adsorption; quasi elastic light scattering; sterile filtration

Indexed keywords

AGGLOMERATION; ELECTROSTATICS; FILTERS (FOR FLUIDS); FILTRATION; HORMONES; IONS; LIGHT SCATTERING; PARTICLE SIZE ANALYSIS; PH; SCANNING ELECTRON MICROSCOPY; SURFACE ACTIVE AGENTS; ZINC;

ELECTROSTATIC REPULSION; FILTER PORES; MEMBRANE FOULING; PROTEIN FILTER MEMBER INTERACTIONS; RECOMBINANT HUMAN GROWTH HORMONE; STERILE FILTRATION;

FOULING;

HUMAN GROWTH HORMONE;

ARTICLE; INFLAMMATION; IONIC STRENGTH; LIGHT SCATTERING; MEMBRANE FORMATION; MEMBRANE TRANSPORT; MICROFILTRATION; NONHUMAN; PARTICULATE MATTER; PROTEIN AGGREGATION; PROTEIN DENATURATION; PROTEIN PROTEIN INTERACTION; SCANNING ELECTRON MICROSCOPY;

EID: 0030570127     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19960505)50:3<319::AID-BIT10>3.0.CO;2-I     Document Type: Article

References (23)

1. Bowen, W. R., Gan, Q. 1991. Properties of microfiltration membranes: Flux loss during constant pressure permeation of bovine serum albumin. Biotechnol. Bioeng. 38: 688-696.
2. Chandavarkar, A. S., Cooney, C. L. 1990. Mathematical modelling of flux decline caused by protein aggregation. ACS National Meeting, Washington, DC, August.
3. Francken, A. C. M., Sluys, J. T. M., Chen, V., Fane, A. G., Fell, C. J. D. 1990. Proc. Fifth World Filtration Congr. 1: 207.
4. Hagelocher, M., Pearlman, R. 1989. Use of cyclodextrin for stabilization of solutions of recombinant human growth hormone. Abstract BT219. Presented at the Fourth Annual meeting of the AAPS. Atlanta, Oct. 22-26.
5. Hsu, C. C., Pearlman, R., Curley, J. 1990. Some factors causing protein denaturation and aggregate formation in pharmaceutical processing. Pharm. Res. 5(10): S-34 (Abstract BT-418).
6. Katakam, M., Bell, L. N., Banga, A. K. 1995. Effect of surfactants on the physical stability of recombinant human growth hormone. J. Pharm. Sci. 84: 713-716.
7. Kelly, S. T., Opong, W. S., Zydney, A. L. 1993. The influence of protein aggregates on the fouling of microfiltration membranes during stirred cell filtration. J. Membr. Sci. 80: 175-187.
8. Kelly, S. T., Zydney, A. L. 1994. Effects of intermolecular thioldisulfide interchange reactions on BSA fouling during microfiltration. Biotechnol. Bioeng. 44: 972-982.
9. Meireles, M., Aimar, P., Sanchez, V. 1991. Effects of protein fouling on the apparent pore size distribution of sieving membranes. J. Membr. Sci. 56: 13-28.
10. Mochizuki, S., Zydney, A. L. 1992. Effect of protein adsorption on the transport characteristics of asymmetric ultrafiltration membranes. Biotechnol. Prog. 8: 553-561.
11. Mochizuki, S., Zydney, A. L. 1993. Sieving characteristics of albumin deposits formed during microfiltration. J. Colloid Interf. Sci. 158: 136-145.
12. Narendranathan, T. J., Dunhill, P. 1982. The effects of shear on globular proteins during ultrafiltration: Studies of alcohol dehydrogenase. Biotechnol. Bioeng. 14: 2103-2107.
13. Nilsson, J. L., Hallstrom, B. 1992. Deviation in the fouling resistance of UF membrane due to clean membrane permeability variations. J. Membr. Sci. 67: 177-189.
14. Opong, W. E., Zydney, A. L. 1991. Hydraulic permeability of protein layers deposited during ultrafiltration. J. Colloid Interf. Sci. 142: 41-60.
15. Pikal, M. J., Dellerman, K. M., Roy, M. L., Riggin, R. M. 1991. The effects of formulation and variables on the stability of freeze-dried human growth hormone. Pharmac. Res. 8: 427-436.
16. Pitt, A. M. 1987. The nonspecific protein binding of polymeric microporous membranes. J. Patenteral Sci. Technol. 41: 110-113.
17. Robertson, B. C., Zydney, A. L. 1990. Hindered protein diffusion in asymmetric ultrafiltration membranes with highly constricted pores. J. Membr. Sci. 49: 287-303.
18. Robertson, B. C., Zydney, A. L. 1990. Protein adsorption in asymmetric ultrafiltration membranes with highly constricted pores. J. Colloid Interf. Sci. 134: 563-575.
19. Thomas, C. R., Nienow, A. W., Dunhill, P. 1979. Action of shear on enzymes: Studies with alcohol dehydrogenase. Biotechnol. Bioeng. 21: 2263-2278.
20. Thomas, C. R., Dunhill, P. 1979. Action of shear on enzymes: Studies with catalase and urease. Biotechnol. Bioeng. 21: 2279-2302.
21. Virkar, P. D., Narendranathan, T. J., Hoare, M., Dunhill, P. 1981. Studies of effects of shear on globular proteins: Extension to high shear fields and to pumps. Biotechnol. Bioeng. 13: 425-429.
22. Wong, H. J., Quinn, J. L. 1976. pp. 169-180. In: M. Kerker (ed.), Colloid and interface science, vol. 5. Academic, New York.
23. Zeman, L. J. 1981. Adsorption effects in rejection of macromolecules by ultrafiltration membranes. J. Membr. Sci. 15: 213-230.