Different in vitro systems affect CYPIA1 activity in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin

Toxicology in Vitro

Volumn 12, Issue 3, 1998, Pages 259-272

  Mufti, N A ^a   Shuler, M L ^a  

^a Cornell University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ARTICLE; COMPARTMENT MODEL; DOSE RESPONSE; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ENZYME INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; RISK ASSESSMENT;

EID: 0031821339     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(97)00114-8     Document Type: Article

References (25)

1. Aden D. P., Fogel A., Plotkin S., Damjanov I., Knowles B. B. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature. 282:1979;615-616.
2. Brown M. M., McCready T. L., Bunce N. J. Factors affecting the toxicity of dioxin-like toxicants: a molecular approach to risk assessment of dioxins. Toxicology Letters. 61:1992;141-147.
3. Buckley L. A. Biologically-based models of dioxin pharmacokientics. Toxicology. 102:1995;125-131.
4. Burke M. D., Mayer R. T. Ethoxyresorufin: direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metabolism and Disposition. 2:1974;583-588.
5. Burke M. D., Thompson S., Elcombe C. R., Halpert J., Haaparanta T., Mayer R. T. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochemical Pharmacology. 34:1985;3337-3345.
6. Crestill T., Jaiswal A. K., Eisen H. J. Transcriptional control of human cytochrome P1-450 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human tissue culture cell lines. Archives of Biochemistry and Biophysics. 253:1987;233-240.
7. Dippold W. G., Dienes H.-P., Knuth A., Sachsse W., Prellwitz W., Bitter-Suermann D., Zum Buschenfelde K.-H. M. Hepatocellular carcinoma after thorotrast exposure: establishment of a new cell line (Mz-Hep-1). Hepatology. 5:1985;1112-1119.
8. Drahushuk A. T., McGarrigle B. P., Tai H. L., Kitareewan S., Goldstein J. A., Olson J. R. Validation of precision-cut liver slices in dynamic organ culture as an in vitro model for studying CYPIA1 and CYPIA2 induction. Toxicology and Applied Pharmacology. 140:1996;393-403.
9. Fernandez-Salguero P. M., Hilbert D. M., Rudikoff S., Ward J. M., Gonzalez F. J. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicology and Applied Pharmacology. 140:1996;173-179.
10. Forestell S. P., Kalogerakis N., Behie L. A. Development of the optimal inoculation conditions for microcarrier cultures. Biotechnology and Bioengineering. 39:1992;305-313.
11. Henderson L. O., Patterson D. G. J. Distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human whole blood and its association with, and extractability from lipoproteins. Bulletin of Environmental Contamination and Toxicology. 40:1988;604-611.
12. Jaiswal A. K., Nebert D. W., Eisen H. W. Comparison of aryl hydrocarbon hydroxylase and acetanilide 4-hydroxylase induction by polycyclic aromatic compounds in human and mouse cell lines. Biochemical Pharmacology. 34:1985;2721-2731.
13. Kohn M. C., Lucier G. W., Clark G. C., Sewall C., Tritscher A. M., Portier C. J. A mechanistic model of effects of dioxin on gene expression in the rat liver. Toxicology and Applied Pharmacology. 120:1993;138-154.
14. Lucier G. W., Portier C. J., Gallo M. A. Receptor mechanisms and dose-response models for the effects of dioxin. Environmental Health Perspectives. 101:1993;36-44.
15. Mills J. J., Andersen M. E. Dioxin hepatic carcinogenesis: biologically motivated modeling and risk assessment. Toxicology Letters. 68:1993;177-189.
16. Mufti N. A. (1995) The design of an in vitro model to study exposures to 2,3,7,8-tetrachlorodibenzo-p-dioxin and a novel assessment of microcarrier-attached cell stress. PhD Thesis.
17. Mufti N. A., Bleckwenn N. A., Babish J. G., Shuler M. L. Possible Involvement of the Ah receptor in the induction of cytochrome P-450IA1 under conditions of hydrodynamic shear in microcarrier-attached hematoma cell lines. Biochemical and Biophysical Research Communications. 208:(1):1995;144-152.
18. Mufti N. A., Shuler M. L. Induction of cytochrome P-450IA1 activity in response to sublethal stresses in microcarrier-attached HepG2 cells. Biotechnology Progress. 11:1995;659-663.
19. Portier C., Tritscher A., Kohn M., Sewall C., Clark G., Edler L., Hoel D., Lucier G. Ligand/receptor binding for 2,3,7,8-TCDD: implications for risk assessment. Fundamental and Applied Toxicology. 20:1993;48-56.
20. Roberts E. A., Johnson K. C., Dippold W. G. Ah receptor mediating induction of cytochrome P450IA1 in a novel continuous human liver cell line (Mz-Hep-1). Biochemical Pharmacology. 42:1991;521-528.
21. Roberts E. A., Johnson K. C., Harper P. A., Okey A. B. Characterization of the Ah receptor mediating aryl hydrocarbon hydroxylase induction in the human liver cell line HepG2. Archives of Biochemistry and Biophysics. 276:1990;442-450.
22. Safe S. H. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annual Review of Pharmacology and Toxicology. 26:1986;371-399.
23. Sewall C. H., Bell D. A., Clark G. C., Tritscher A. M., Tully D. B., VandenHeuvel J., Lucier G. W. Induced gene transcription: implications for biomarkers. Clinical Chemistry. 41:1995;1829-1834.
24. Sweeney L. M., Shuler M. L., Babish J. G., Ghanem A. A cell culture analogue of rodent physiology: application to naphthalene toxicology. Toxicology in Vitro. 9:1995;307-316.
25. van Wezel A. L. (1973) Microcarrier cultures of animal cells. In Tissue Culture: Methods and Applications. Edited by P. F. Kruse, Jr and M. K. Patterson, Jr. pp. 372-377. Academic Press, New York.