Response to interferon therapy: Influence of human leucocyte antigen alleles in patients with chronic hepatitis C

Journal of Viral Hepatitis

Volumn 5, Issue 4, 1998, Pages 249-253

  Sim, H ^a   Wojcik, J ^a   Margulies, M ^a   Wade, J A ^a   Heathcote, J ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Hepatitis C; Human leucocyte antigen; Interferon

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; DNA; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DR ANTIGEN;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; HEPATITIS C; HUMAN; IMMUNOTHERAPY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ALANINE TRANSAMINASE; ALLELES; ANTIVIRAL AGENTS; FEMALE; HEPATITIS C, CHRONIC; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; INTERFERON-ALPHA; LEUKOCYTES; MALE; MIDDLE AGED;

EID: 0031821318     PISSN: 13520504     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2893.1998.00111.x     Document Type: Article

References (19)

1. Parham P, Adams EJ, Arnett KL. The origins of HLA-A,B,C polymorphism. Immunol Rev 1995; 143: 141-180.
2. Racioppi L, Ronchese F, Schwartz RH, Germain RN. The molecular basis of class IIMHC allelic control of T cell responses. J Immunol 1991; 147: 3718-3727.
3. Marousis CG, She JX, She JY et al. Hepatology 1995; 22: 349 (abstr).
4. Cramp ME, Carucci P, Donaldson PT et al. Evidence that HLA class II genotype may be associated with clearance of hepatitis C virus. Hepatology 1996; 24: 151 (abstr).
5. Blair CS, Haydon GH, McColl M et al. HLA status and severity and progression of chronic hepatitis C virus infection. Hepatology 1996; 24: 149 (abstr).
6. Haruna Y, Miyamoto T, Kanda T et al. Histopathological findings in livers of chronic hepatitis C are associated with human leukocyte antigen DR. Hepatology 1996; 24: 383 (abstr).
7. Battegay M, Fikes J, Di Bisceglie AM et al. Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules. J Virol 1995; 69: 2462-2470.
8. Cerny A, McHutchison JG, Pasquinelli C et al. Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J Clin Invest 1995; 95: 521-530.
9. Koziel MJ, Dudley D, Afdhal N et al. HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest 1995; 96: 2311-2321.
10. Yshioka K, Kakumu S, Wakita T et al. Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alfa therapy: relation to genotypes of hepatitis C virus. Hepatology 1992; 6: 293-299.
11. Hagiwara H, Hayashi N, Mita E et al. Quantitative analysis of hepatitis C virus RNA in serum during interferon-alfa therapy. Gastroenterology 1993; 104: 877-883.
12. Simmonds P. Variability of hepatitis C virus. Hepatology 1995; 21: 570-583.
13. Enomoto N, Sakuma I, Asahina Y et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. New Engl J Med 1996; 334: 77-81.
14. Chemello L, Cavalletto L, Casarin C et al. Persistent hepatitis C viremia predicts late relapse after sustained response to interferon-alpha in chronic hepatitis C. Ann Intern Med 1996; 124: 1058-1060.
15. Olerup O, Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens 1992; 39: 225-235.
16. Shaffer A, Wade JA, Tortorelli V et al. HLA-DRw52-associated DRB1 alleles: identification using polymerase chain reaction amplified DNA, sequence specific oligonucleotide probes, and a chemiluminescent detection system. Tissue Antigens 1992; 39: 84-90.
17. Wade JA, Hurley CK, Hastings A et al. Combinational diversity in DR2 haplotypes. Tissue Antigens 1993; 41: 113-118.
18. Vitte RL, Fortier C, Richardet JP et al. HLA antigens in patients with chronic hepatitis C. Tissue Antigens 1995; 45: 356-361.
19. Thomson G. HLA disease associations: models for the study of complex human genetic disorders. Crit Rev Clin Lab Sci 1995; 32: 183-219.