Expression of the MRP and MDR1 multidrug resistance gene products in 160 untreated human carcinomas studied by immunohistochemical methods in formalin-paraffin sections

International Journal of Surgical Pathology

Volumn 6, Issue 3, 1998, Pages 145-154

  Tóth, Károly ^a   Vaughan, Mary M ^a   Schwartz, Gary ^b   Winston, Janet S ^b   Skenderis II, Basil S ^b   Slocum, Harry K ^a   Rustum, Youcef M ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Human cancers; Immunohistochemistry; JSB 1; MAbs MRPm6; Multidrug resistance associated protein; P glycoprotein

Indexed keywords

GENE PRODUCT; GLYCOPROTEIN P; MONOCLONAL ANTIBODY;

ARTICLE; BLADDER CANCER; BREAST CANCER; CANCER; COLORECTAL CANCER; GENE OVEREXPRESSION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CANCER; MULTIDRUG RESISTANCE; OVARY CANCER; PRIORITY JOURNAL; TUMOR CELL LINE;

EID: 0031820924     PISSN: 10668969     EISSN: None     Source Type: Journal    
DOI: 10.1177/106689699800600303     Document Type: Article

References (46)

1. Beck WT, Dalton WS. Mechanism of drug resistance. In DeVita VT, Hellman S, Rosenberg SA (eds). Cancer. Principles and practice of oncology. 5th ed. Lippincott-Raven, Philadelphia, pp. 498-512, 1997
2. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AMV, Deeley RG. Overexpression of a transporter gene in a multidrug-resistant human cancer cell line. Science 258:1650-1654, 1992
3. Krishnamachary N, Center MS. The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein. Cancer Res 53:3658-3661, 1993
4. Grant CE, Valdimarsson G, Hipfner DR, Almquist KC, Cole SPC, Deeley RG. Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs. Cancer Res 54:357-361, 1994
5. Zaman GJR, Flens MJ, van Leusden MR, de Haas M, Muelder HS, Lankelma J, Pinedo HM, Scheper RJ, Broxterman HJ, Borst P. The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump. Natl Acad Sci USA 91:8822-8826, 1994
6. Breuniger LM, Paul S, Gaughan K, Miki T, Chan A, Aaronson SA, Kruh GD. Expression of multidrug resistance-associated protein in NIH/3T3 cells confers multidrug resistance-associated with increased drug efflux and altered intracellular drug distribution. Cancer Res 55:5342-5347, 1995
7. Cole SPC, Sparks KE, Fraser K, Loe DW, Grant CE, Wilson GM, Deeley RG. Pharmacological characterization of multidrug-resistant MRP-transfected human tumor cells. Cancer Res 54:5902-5910, 1994
8. Burger H, Nooter K, Zaman GJR, Sonnevald P, van Wingerden KE, Oostrum RG, Stoter G. Expression of the multidrug resistance-associated protein (MRP) in acute and chronic leukemias. Leukemia 8:990-997, 1994
9. Burger H, Nooter K, Sonneveld P, van Wingerden KE, Zaman GJ, Stoter G. Higher expression of the multidrug resistance-associated protein (MRP) in chronic and prolymphocytic leukemia. Br J Haematol 88:348-356, 1994
10. Abbaszadegan MR, Futscher BW, Klimecki WT, List A, Dalton WS. Analysis of multidrug resistance-associated protein (MRP) messenger RNA in normal and malignant hematopoietic cells. Cancer Res 54: 4676-4679, 1994
11. Bordow SB, Haber M, Madafiglio J, Cheung B, Marshall GM, Norris MD. Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. Cancer Res 54:5036-5040, 1994
12. Thomas GA, Barrand MA, Stewart S, Rabbitts PH, Williams ED, Twentyman PR. Expression of the multidrug resistance-associated protein (MRP) gene in human lung tumors and normal tissues as determined by in situ hybridization. Eur J Cancer 30A:1705-1709, 1994
13. Nooter K, Westerman AM, Flens MJ, Zaman GJR, Scheper RJ, van Wingerden KE, Burger H, Oostrum R, Boersma T, Sonneveld P, Gratama JW, Kik T, Eggermont AMM, Bosman FR, Stoter G. Expression of the multidrug resistance-associated protein (MRP) gene in human cancers. Clin Cancer Res 1:1301-1310, 1995
14. Sugawara I, Yamada H, Nakamura H, Sumizawa T, Akiyama S, Masunaga A, Itoyama S. Preferential expression of the multidrug-resistance-associated protein (MRP) in adenocarcinoma of the lung. Int J Cancer (Pred Oncol) 64:322-325, 1995
15. Schadendorf D, Makki A, Stahr C, van Dyck A, Wanner R, Scheffer GL, Flens MJ, Scheper R, Henz BM. Membrane transport proteins associated with drug resistance expressed in human melanoma. Am J Pathol 147:1545-1552, 1995
16. Nooter K, Bosman FT, Burger H, van Wingerden KE, Glens MJ, Scheper RJ, Oostrum RG, Boersman AWM, van der Gaast A, Stoter G. Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer. Ann Oncol 7:75-81, 1996
17. Chuman Y, Suimizawa T, Takebayashi Y, Niwa K, Yamada K, Haraguchi M, Furukawa T, Akiyama S, Aikou T. Expression of the multidrug-resistance-associated protein (MRP) gene in human colorectal, gastric and non-small-cell lung carcinomas. Int J Cancer 66:274-279, 1996
18. Filipits M, Suchomel RW, Dekan G, Haider K, Valdimarsson G, Depisch D, Pirker R. MRP and MDR1 gene expression in primary breast carcinomas. Clin Cancer Res 2:1231-1237, 1996
19. Campling BG, Young LC, Baer KA, Lam Y-M, Deeley RG, Cole SPC, Gerlach JH. Expression of the MRP and MDR1 multidrug resistance genes in small cell lung cancer. Clin Cancer Res 3:115-122, 1997
20. Filipits M, Suchomel RW, Dekan G, Stiglbauer W, Haider K, Depisch D, Pirker R. Expression of the multidrug resistance-associated protein (MRP) gene in colorectal carcinomas. Br J Cancer 75:208-212, 1997
21. Flens MJ, Zaman GJR, van der Valk P, Izquierdo MA, Schroeijers AB, Scheffer GL, van der Groep P, de Haas M, Meijer CJLM, Scheper RJ. Tissue distribution of the multidrug resistance protein. Am J Pathol 148:1237-1247, 1996
22. Flens MJ, Izquierdo MA, Scheffer GL, Fritz JM, Meijer CJLM, Scheper RJ, Zaman GJR. Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. Cancer Res 54:4557-4563, 1994
23. r 190,000 multidrug resistance protein, MRP, with monoclonal antibodies. Cancer Res 5788-5792, 1994
24. Tóth K, Vaughan MM, Schwartz G, Winston JS, Skenderis BS II, Slocum HK, Rustum YM. MRP and MDR1 expression in 160 human untreated carcinomas studied by immunohistochemical methods in formalin-paraffin sections. Proc ASCO 16:542a, 1997
25. Marsh W, Sicheri D, Center MS. Isolation and characterization of adriamycin-resistant HL-60 cells which are not defective in the initial intracellular accumulation of drug. Cancer Res 46:4053-4057, 1986
26. Slovak ML, Hoeltge GA, Dalton WS, Trent JM. Pharmacological and biochemical evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines. Cancer Res 48:2793-2797, 1988
27. Slovak ML, Ho JP, Bhardwaj G, Kurz EU, Deeley RG, Cole SPC. Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines. Cancer Res 53: 3221-3225, 1993
28. Slovak ML, Ho JP, Cole SPS, Deeley RG, Greenberger L, de Vries EGE, Broxterman HJ, Scheffer GL, Scheper RJ. The LRP gene encoding a major vault protein associated with drug resistance maps proximal to MRP on chromosome 16: Evidence that chromosome breakage plays a key role in MRP or LRP gene amplification. Cancer Res 55:4214-4219, 1995
29. Krishnamachary N, Liangdong MA, Zheng L, Safa AR, Center MS. Analysis of MRP gene expression and function in HL60 cells isolated for resistance to adriamycin. Oncol Res 6:119-127, 1994
30. Tóth K, Vauglian MM, Slocum HK, Arredondo MA, Takita H, Baker RM, Rustum YM. New immunohistochemical "sandwich" staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embedded human tissues. Am J Pathol 144:227-236, 1994
31. Tóth K, Vaughan MM, Peress NS, Slocum HK, Rustum YM. MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors. Am J Pathol 149:853-858, 1996
32. Vanhoefer U, Cao S, Minderman H, Tóth K, Scheper RJ, Slovak ML, Rustum YM. PAK-104P, a pyridine analogue, reverses paclitaxel and doxorubicin resistance in cell lines and nude mice bearing xenografts that overexpress the multidrug resistance protein. Clin Cancer Res 2:369-377, 1996
33. Shi S-R, Key ME, Kalra KL. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 6:741-748, 1991
34. Shi S-R, Chaiwun B, Young L, Cote RJ, Taylor CR. Antigen retrieval technique utilizing citrate buffer or urea solution for immunohistochemical demonstration of androgen receptor in formalin-fixed paraffin sections. J Histochem Cytochem 41:1599-1604, 1993
35. Cuevas EC, Bateman AC, Wilkins BS, Johnson PA, Williams JH, Lee AHS, Jones DB, Wright DHJ. Microwave antigen retrieval in immunocytochemiistry: A study of 80 antibodies. Clin Pathol 47:448-452, 1994
36. Shi S-R, Gu J, Kalra KL, Chen T, Cote RJ, Taylor CR. Antigen retrieval technique: A novel approach to immunohistochemistry on routinely processed tissue sections. Cell Vision 2:6-22, 1995
37. Leong AS-Y, Milios J, Leong FJ. Epitope retrieval with microwaves, a comparison of citrate buffer and EDTA with three commercial retrieval solutions. Appl Immunohistochem 4:201-207, 1996
38. Brock I, Hipfner DR, Nielsen BS, Jensen PB, Deeley RG, Cole SPC, Sehested M. Sequential coexpression of the multidrug resistance genes MRP and mdr1 and their products in VP-16 (Etoposide)-selected H69 small cell lung cancer cells. Cancer Res 55:459-462, 1995
39. Lorico Q, Rappa G, Flavell RA, Sartorelli AC. Double knockout of the MRP gene leads to increased drug sensitivity in vitro. Cancer Res 56:5351-5355, 1996
40. Broxterman HJ, Giaccone G, Lankelma J. Multidrug resistance proteins and other drug transport-related resistance to natural product agents. Curr Opin Oncol 7:532-540, 1995
41. Vanhoefer U, Cao S, Minderman H, Toth K, Skenderis BS II, Slovak ML, Rustum YM. D,L-buthionine-(S,R)-sulfoximine potentiates in vivo the therapeutic efficacy of doxorubicin against multidrug resistance protein-expressing tumors. Clin Cancer Res 2:1961-1968, 1996
42. Pendyala L, Velagapudi S, Tóth K, Zdanowicz J, Glaves D, Slocum H, Perez R, Huben R, Creaven PJ, Raghavan D. Translational studies of glutathione in bladder cancer cell lines and human specimens. Clin Cancer Res 3:793-798, 1997
43. Norris MD, Bordow SB, Marshall GM, Haber PS, Cohn SL, Haber M. Expression of the gene for multidrug-resistance-associated protein and outcome in patients with neuroblastoma. N Engl J Med 334: 231-238, 1996
44. Nooter N, Grutel de la Riviere G, Look MP, van Wingerden KE, Henzen-Logmans SC, Scheper RJ, Flens MJ, Klijn JGM, Stoter G, Foekens JA. The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer. Br J Cancer 76:486-493, 1997
45. Chan HSL, Lu Y, Grogan TM, Haddad G, Hipfner DR, Cole SPC, Deeley RG, Long V, Gallic BL. Multidrug resistance protein (MRP) expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein. Cancer Res 57:2325-2330, 1997
46. Beck WT, Grogan TM, Willman L, Cordon-Cardo C, Parham DM, Kuttesch JF, Andreeff M, Bates SE, Berard CW, Boyett JM, Brophy NA, Broxterman HJ, Chan HSL, Dalton WS, Dietel M, Fojo AT, Gascoyne RD, Head D, Houghton PJ, Srivastava DK, Lehnert M, Leith CP, Paietta E, Pavelic ZP, Rimsza L, Roninson IB, Sikic BI, Twentyman PR, Warnke R, Weinstein R. Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: Consensus recommendations. Cancer Res 56: 3010-3020, 1996