메뉴 건너뛰기




Volumn 15, Issue 7, 1998, Pages 1063-1068

Effects of nitro-L-arginine on blood pressure and cardiac index in anesthetized rats: A pharmacokinetic-pharmacodynamic analysis

Author keywords

Hemodynamic effects; Nitric oxide (NO); Nitric oxide synthesis (NO); Nitro L arginine (L NA); Pharmacodynamics (PD); Pharmacokinetics (PK)

Indexed keywords

N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR;

EID: 0031820908     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011986312541     Document Type: Article
Times cited : (5)

References (25)
  • 1
    • 0028863627 scopus 로고
    • Molecular mechanisms and therapeutic strategies related to nitric oxide
    • S. Moncada and E. A. Higgs. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J. 9:1319-30 (1995).
    • (1995) FASEB J. , vol.9 , pp. 1319-1330
    • Moncada, S.1    Higgs, E.A.2
  • 4
    • 0025828338 scopus 로고
    • Cardiovascular actions of inhibitors of endothelium-derived relaxing factor (nitric oxide) formation/release in anesthetized dogs
    • R. E. Klabunde, R. C. Ritger, and M. C. Helgren. Cardiovascular actions of inhibitors of endothelium-derived relaxing factor (nitric oxide) formation/release in anesthetized dogs. Eur. J. Pharmacol. 199:51-9 (1991).
    • (1991) Eur. J. Pharmacol. , vol.199 , pp. 51-59
    • Klabunde, R.E.1    Ritger, R.C.2    Helgren, M.C.3
  • 5
    • 0031112190 scopus 로고    scopus 로고
    • Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: Lessons learned from experimental and clinical studies
    • R. G. Kilbourn, C. Szabo, and D. L. Traber. Beneficial versus detrimental effects of nitric oxide synthase inhibitors in circulatory shock: lessons learned from experimental and clinical studies. Shock 7:235-46 (1997).
    • (1997) Shock , vol.7 , pp. 235-246
    • Kilbourn, R.G.1    Szabo, C.2    Traber, D.L.3
  • 6
    • 0028144708 scopus 로고
    • Inhibition of nitric oxide synthesis is detrimental during endotoxemia
    • E. A. Minnard, J. Shou, H. Naama, A. Cech, H. Gallagher, and J. M. Daly. Inhibition of nitric oxide synthesis is detrimental during endotoxemia. Arch. Surg. 129:142-7 (1994).
    • (1994) Arch. Surg. , vol.129 , pp. 142-147
    • Minnard, E.A.1    Shou, J.2    Naama, H.3    Cech, A.4    Gallagher, H.5    Daly, J.M.6
  • 7
    • 0028157456 scopus 로고
    • Detrimental hemodynamic effects of nitric oxide synthase inhibition in septic shock
    • F. M. Robertson, P. J. Offner, D. P. Ciceri, W. K. Becker, and B. A. Pruitt, Jr. Detrimental hemodynamic effects of nitric oxide synthase inhibition in septic shock. Arch. Surg. 129:149-55 (1994).
    • (1994) Arch. Surg. , vol.129 , pp. 149-155
    • Robertson, F.M.1    Offner, P.J.2    Ciceri, D.P.3    Becker, W.K.4    Pruitt Jr., B.A.5
  • 8
    • 0030006967 scopus 로고    scopus 로고
    • Reversed-phase high-performance liquid chromatography method for the analysis of nitroarginine in rat plasma and urine
    • M. A. Tabrizi-Fard and H. L. Fung. Reversed-phase high-performance liquid chromatography method for the analysis of nitroarginine in rat plasma and urine. J. Chromatog. B: Biom. Applica. 679:7-12 (1996).
    • (1996) J. Chromatog. B: Biom. Applica. , vol.679 , pp. 7-12
    • Tabrizi-Fard, M.A.1    Fung, H.L.2
  • 9
    • 0023450020 scopus 로고
    • Simultaneous modeling of pharmacokinetics and pharmacodynamics: An improved algorithm
    • D. Verotta and L. B. Sheiner. Simultaneous modeling of pharmacokinetics and pharmacodynamics: an improved algorithm. CABIOS 3:345-9 (1987).
    • (1987) CABIOS , vol.3 , pp. 345-349
    • Verotta, D.1    Sheiner, L.B.2
  • 10
    • 0022503230 scopus 로고
    • Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models
    • J. D. Unadkat, F. Bartha, and L. B. Sheiner. Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models. Clin. Pharmacol. Ther. 40:86-93 (1986).
    • (1986) Clin. Pharmacol. Ther. , vol.40 , pp. 86-93
    • Unadkat, J.D.1    Bartha, F.2    Sheiner, L.B.3
  • 11
    • 0018394195 scopus 로고
    • Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine
    • L. B. Sheiner, D. R. Stanski, S. Vozeh, R. D. Miller, and J. Ham. Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine. Clin. Pharmacol. Ther. 25:358-71 (1979).
    • (1979) Clin. Pharmacol. Ther. , vol.25 , pp. 358-371
    • Sheiner, L.B.1    Stanski, D.R.2    Vozeh, S.3    Miller, R.D.4    Ham, J.5
  • 12
    • 0027739308 scopus 로고
    • Inhibition of nitric oxide synthesis increases blood pressure in healthy humans
    • W. G. Haynes, J. P. Noon, B. R. Walker, and D. J. Webb. Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J. Hypertension. 11:1375-80 (1993).
    • (1993) J. Hypertension , vol.11 , pp. 1375-1380
    • Haynes, W.G.1    Noon, J.P.2    Walker, B.R.3    Webb, D.J.4
  • 13
    • 0025812495 scopus 로고
    • Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: Evidence for continuous basal EDRF release
    • H. M. Vargas, J. M. Cuevas, L. J. Ignarro, and G. Chaudhuri. Comparison of the inhibitory potencies of N(G)-methyl-, N(G)-nitro- and N(G)-amino-L-arginine on EDRF function in the rat: evidence for continuous basal EDRF release. Journal of Pharmacology & Experimental Therapeutics. 257:1208-15 (1991).
    • (1991) Journal of Pharmacology & Experimental Therapeutics , vol.257 , pp. 1208-1215
    • Vargas, H.M.1    Cuevas, J.M.2    Ignarro, L.J.3    Chaudhuri, G.4
  • 14
    • 0019785890 scopus 로고
    • Understanding the dose-effect relationship: Clinical application of pharmacokinetic-pharmacodynamic models
    • N. H. Holford and L. B. Sheiner. Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models. Clin. Pharmacokin. 6:429-53 (1981).
    • (1981) Clin. Pharmacokin. , vol.6 , pp. 429-453
    • Holford, N.H.1    Sheiner, L.B.2
  • 15
    • 0027943266 scopus 로고
    • Physiologic indirect response models characterize diverse types of pharmacodynamic effects
    • W. J. Jusko and H. C. Ko. Physiologic indirect response models characterize diverse types of pharmacodynamic effects. Clin. Pharmacol. Ther. 56:406-19 (1994).
    • (1994) Clin. Pharmacol. Ther. , vol.56 , pp. 406-419
    • Jusko, W.J.1    Ko, H.C.2
  • 16
    • 0028140141 scopus 로고
    • Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation
    • P. Klatt, K. Schmidt, F. Brunner, and B. Mayer. Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation. J. Biol. Chem. 269:1674-80 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 1674-1680
    • Klatt, P.1    Schmidt, K.2    Brunner, F.3    Mayer, B.4
  • 17
    • 0027184034 scopus 로고
    • Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine
    • E. S. Furfine, M. F. Harmon, J. E. Paith, and E. P. Garvey. Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine. Biochemistry. 32:8512-7 (1993).
    • (1993) Biochemistry , vol.32 , pp. 8512-8517
    • Furfine, E.S.1    Harmon, M.F.2    Paith, J.E.3    Garvey, E.P.4
  • 18
    • 0027769745 scopus 로고
    • Comparison of four basic models of indirect pharmacodynamic responses
    • N. L. Dayneka, V. Garg, and W. J. Jusko. Comparison of four basic models of indirect pharmacodynamic responses. J. Pharmacokin. Biopharm. 21:457-78 (1993).
    • (1993) J. Pharmacokin. Biopharm. , vol.21 , pp. 457-478
    • Dayneka, N.L.1    Garg, V.2    Jusko, W.J.3
  • 19
    • 0027070714 scopus 로고
    • Pharmacodynamic modeling of the in vitro vasodilating effects of organic mononitrates
    • T. B. Tzeng and H. L. Fung. Pharmacodynamic modeling of the in vitro vasodilating effects of organic mononitrates. J. Pharmacokin. Biopharm. 20:227-51 (1992).
    • (1992) J. Pharmacokin. Biopharm. , vol.20 , pp. 227-251
    • Tzeng, T.B.1    Fung, H.L.2
  • 20
    • 0024428094 scopus 로고
    • Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
    • P. Vallance, J. Collier, and S. Moncada. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 2:997-1000 (1989).
    • (1989) Lancet , vol.2 , pp. 997-1000
    • Vallance, P.1    Collier, J.2    Moncada, S.3
  • 21
    • 0027053340 scopus 로고
    • Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia
    • A. J. Brady, P. A. Poole-Wilson, S. E. Harding, and J. B. Warren. Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia. Am. J. Physiol. 263:H1963-6 (1992).
    • (1992) Am. J. Physiol. , vol.263
    • Brady, A.J.1    Poole-Wilson, P.A.2    Harding, S.E.3    Warren, J.B.4
  • 22
    • 0025123927 scopus 로고
    • Regional and cardiac haemodynamic effects of NG-nitro-L-argi-nine methyl ester in conscious, Long Evans rats
    • S. M. Gardiner, A. M. Compton, P. A. Kemp, and T. Bennett. Regional and cardiac haemodynamic effects of NG-nitro-L-argi-nine methyl ester in conscious, Long Evans rats. Brit. J. Pharmacol. 101:625-31 (1990).
    • (1990) Brit. J. Pharmacol. , vol.101 , pp. 625-631
    • Gardiner, S.M.1    Compton, A.M.2    Kemp, P.A.3    Bennett, T.4
  • 23
    • 0018096305 scopus 로고
    • Comparative stability of physiological parameters during sustained anesthesia in rats
    • J. Buelke-Sam, J. F. Holson, J. J. Bazare, and J. F. Young. Comparative stability of physiological parameters during sustained anesthesia in rats. Lab. Animl. Sci. 28:157-62 (1978).
    • (1978) Lab. Animl. Sci. , vol.28 , pp. 157-162
    • Buelke-Sam, J.1    Holson, J.F.2    Bazare, J.J.3    Young, J.F.4
  • 24
    • 0028213155 scopus 로고
    • Pharmacokinetics, plasma protein binding and urinary excretion of N omega-nitro-L-arginine in rats
    • M. A. Tabrizi-Fard and H. L. Fung. Pharmacokinetics, plasma protein binding and urinary excretion of N omega-nitro-L-arginine in rats. Brit. J. Pharmacol. 111:394-6 (1994).
    • (1994) Brit. J. Pharmacol. , vol.111 , pp. 394-396
    • Tabrizi-Fard, M.A.1    Fung, H.L.2
  • 25
    • 0030457690 scopus 로고    scopus 로고
    • Pharmacokinetics and steady-state tissue distribution of L- and D-isomers of nitroarginine in rats
    • M. A. Tabrizi-Fard and H. L. Fung. Pharmacokinetics and steady-state tissue distribution of L- and D-isomers of nitroarginine in rats. Drug Metab. Dispos. 24:1241-6 (1996).
    • (1996) Drug Metab. Dispos. , vol.24 , pp. 1241-1246
    • Tabrizi-Fard, M.A.1    Fung, H.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.