Biphasic effects of cyclosporin A on formyl-methionyl-leucyl-phenylalanine stimulated responses in HL-60 cells differentiated into neutrophils

British Journal of Pharmacology

Volumn 124, Issue 8, 1998, Pages 1774-1780

  Nguyen, Nathalie S D ^a   Pulido, Silvia M ^a   Rüegg, Urs T ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Calcineurin; Calcium; Cyclophilin; Cyclosporin; Degranulation; HL 60 cells; Multi drug resistance transporter; Neutrophil; Reactive oxygen species

Indexed keywords

BETA GLUCURONIDASE; CALCIUM ION; CYCLOPHILIN; CYCLOSPORIN A; DIMETHYL SULFOXIDE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; REACTIVE OXYGEN METABOLITE; VALSPODAR;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; NEUTROPHIL; PRIORITY JOURNAL; RESPIRATORY BURST;

CALCIUM; CELL DIFFERENTIATION; CELL SURVIVAL; CYCLOSPORINE; CYCLOSPORINS; DIMETHYL SULFOXIDE; ETHANOL; GLUCURONIDASE; HL-60 CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; REACTIVE OXYGEN SPECIES; SOLVENTS;

EID: 0031819519     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702020     Document Type: Article

References (32)

1. ABSOLOM, D. R. (1986). Basic methods for the study of phagocytosis. Meth. in Enzymol., 132, 95-180.
2. 2]-Cyclosporine), a multidrug resistance modulator, with P-glycoprotein. Oncol. Res., 7, 603-610.
3. BAUKAL, A.J., HUNYADY, L., CATT, K.J. & BALLA, T. (1994). Evidence for participation of calcineurin in potentiation of agonist-stimulated cyclic AMP formation by the calcium-mobilizing hormone, Angiotensin II. J. Biol. Chem., 269, 24546-24549.
4. BOESCH, D., MULLER, K., POURTIER-MANZANEDO, A. & LOOR, F. (1991). Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a non immunosuppressive cyclosporin derivative. Exp. Cell Res., 196, 26-32.
5. BOREL, J.F., BAUMANN, G., CHAPMAN, I., DONATSCH, P., FAHR, A., MUELLER, E.A. & VIGOURET, J.M. (1996). In vivo pharmacological effects of ciclosporin and some analogues. Adv. Pharmacol., 35, 115-246.
6. BROXTERMAN, H.J., GIACCONE, G. & LANKELMA, J. (1995). Multidrug resistance proteins and other drug transport-related resistance to natural product agents. Curr. Opin. in Oncol., 7, 532-540.
7. CHARUK, J.H., WONG, P.Y. & REITHMEIER, R.A. (1995). Differential interaction of human renal P-glycoprotein with various metabolites and analogues of cyclosporin A. Am. J. Physiol., 269, F31-F39.
8. FAHR, A. (1993). Cyclosporin clinical pharmacokinetics. Clin. Pharmacokinet., 24, 472-495.
9. FLIRI, H., BAUMANN, G., ENZ, A., KALLEN, J., LUYTEN, M., MIKOL, V., MOVVA, R., QUESNIAUX, V., SCHREIER, M., WALKINSHAW, M., WENGER, R, ZENKE, G. & ZURINI M. (1993). Cyclosporins. Structure-activity relationships. Ann. N. Y. Acad. Sci., 696, 47-53.
10. FOXWELL, B.M., MACKIE, A., LING, V. & RYFFEL, B. (1989). Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein. Mol. Pharmacol., 36, 543-546.
11. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem., 260, 3440-3450.
12. KLINKER, J.F., WENZEL-SEIFERT, K. & SEIFERT, R. (1996). G-protein-coupled receptors in HL-60 human leukemia cells. Gen. Pharmacol., 27, 33-54.
13. KUNZ, J. & HALL, M.N. (1993). Cyclosporin A, FK506 and rapamycin: More than just immunosuppression. Trends Biochem. Sci., 18, 334-338.
14. KUROKAWA, T., NONAMI, T., KOBAYASHI, H., KISHIMOTO, W., UCHIDA, K., TAKAGI, H., SUGIYAMA, S. & OZAWA, T. (1992). Inhibition by cyclosporine of the production of superoxide radicals. N. Engl. J. Med., 326, 840.
15. LEUNG, Y.M., KWAN, C.Y. & LOH, T.T (1996). Dual effects of SK&F 96365 in human leukemic HL-60 cells. Inhibition of calcium entry and activation of a novel cation influx pathway. Biochem. Pharmacol., 51, 605-612.
16. LEVY, R., ROTROSEN, D., NAGAUKER, O., LETO, T.L. & MALECH, H.L. (1990). Induction of the respiratory burst in HL-60 cells. Correlation of function and protein expression. J. Immunol., 145, 2595-2601.
17. LO RUSSO A., PASSAQUIN A.C. & RUEGG U.T. (1997). Mechanism of enhanced vasoconstrictor hormone action in vascular smooth muscle cells by cyclosporin A. Br. J. Pharmacol., 121, 248-252.
18. MCKEON, F. (1991). When worlds collide: immunosuppressants meet protein phosphatases. Cell, 66, 823-826.
19. MOREL, F., DOUSSIERE, J. & VIGNAIS, P.V. (1991). The superoxide-generating oxidase of phagocytic cells. Physiological, molecular and pathological aspects. Europ. J. Biochem., 201, 523-546.
20. OYA, Y., YAMAMOTO, K. & TONOMURA, A. (1986). The biological activity of hydrogen peroxide. Induction of chromosome-type aberrations susceptible to inhibition by scavengers of hydroxyl radicals in human embryonic fibroblasts. Mut. Res., 172, 245-253.
21. SCHREIBER, S.L. & CRABTREE, G.R. (1992). The mechanism of action of cyclosporin A and FK506. Immunol. Today, 13, 136-142.
22. SEGAL, A.W. & ABO, A. (1993). The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem. Sci., 18, 43-47.
23. SEIFERT, R. & SCHULTZ, G. (1991). The superoxide-forming NADPH oxidase of phagocytes. An enzyme system regulated by multiple mechanisms. Rev. Physiol. Biochem. Pharmacol., 117, 1-338.
24. SIGAL, N.H. & DUMONT, F.J. (1992). Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu. Rev. Immunol., 10, 519-560.
25. TAUBER, A.I. (1987). Protein kinase C and the activation of the human neutrophil NADPH-oxidase. Blood, 69, 711-720.
26. THORAT, S.P., THATTE, U.M., PAI, N. & DAHANUKAR, S.A. (1994). Inhibition of phagocytes by cyclosporin in vitro. Quart. J. Med., 87, 311-314.
27. TIBERGHIEN, F. & LOOR, F. (1996). Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay. Anti-Cancer Drugs, 7, 568-578.
28. WENZEL-SEIFERT, K., GRUNBAUM, L. & SEIFERT, R. (1991). Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation. J. Immunol., 147, 1940-1946.
29. WENZEL-SEIFERT, K. & SEIFERT, R. (1993). Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-leucyl-L- phenylalanine and cyclosporins A, B, C, D, and E. J. Immunol., 150, 4591-4599.
30. 2 produced by human neutrophils during the respiratory burst. Anal. Biochem., 165, 371-378.
31. YASUI, K., YAMAZAKI, M., MIYABAYASHI, M., TSUNO, T. & KOMIYAMA, A. (1994). Signal transduction pathway in human polymorphonuclear leukocytes for chemotaxis induced by a chemotactic factor. Distinct from the pathway for superoxide anion production. J. Immunol., 152, 5922-5929.
32. ZHOU, W.D., ZHANG, H.Q., FANG, M., HE, Q.Y., PANG, D.B. & XUE, S.B. (1996). Induction of expression of MDR 1 gene by retinoic acid and DMSO and effects on rhodamine-123 efflux in HL-60 cell lines and resistant sublines. Acta Pharm. Sinic., 31, 1-5.