Molecular basis of IgE-recognition of Lol p 5, a major allergen of rye- grass pollen

Molecular Immunology

Volumn 35, Issue 5, 1998, Pages 293-305

  Suphioglu, Cenk ^a,c   Blaher, Bella ^b   Rolland, Jennifer M ^b   McCluskey, James ^a   Schappi, George ^a   Kenrick, Jo ^a   Singh, Mohan B ^a   Knox, R Bruce ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c ALFRED HOSPITAL   (Australia)

Author keywords

Allergen; B cells; Cross reactivity; Epitope; IgE binding; Lol p 5; Rye grass pollen; Synthetic peptides

Indexed keywords

EPITOPE; IMMUNOGLOBULIN E; POLLEN ANTIGEN; SYNTHETIC PEPTIDE;

AMINO ACID SEQUENCE; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; CROSS REACTION; GRASS POLLEN; HUMAN; NONHUMAN; POLLEN ALLERGY; PRIORITY JOURNAL;

ALLERGENS; AMINO ACID SEQUENCE; BINDING SITES, ANTIBODY; CONSERVED SEQUENCE; EPITOPES; HUMANS; IMMUNOGLOBULIN E; LOLIUM; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PLANT PROTEINS; POLLEN; SEQUENCE HOMOLOGY, AMINO ACID;

LOLIUM PERENNE; POACEAE; SECALE CEREALE;

EID: 0031818786     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(98)00050-9     Document Type: Article

References (33)

1. Appel, J.R., Pinilla, C., Niman, H., Houghten, R., 1990. Elucidation of discontinuous linear determinant in peptides. J. Immunol. 144, 976-983.
2. Blaher, B., Suphioglu, C., Knox, R.B., Singh, M.B., McCluskey, J., Rolland, J.M., 1996. Identification of T cell epitopes of Lol p 9, a major allergen of rye-grass (Lolium perenne) pollen. J. Allergy Clin. Immunol. 98, 124-32.
3. Bond, J.F., Segal, D.B., Yu, X.-B., Theriault, K.A., Pollock, M.S., Yeung, H., 1993. Human IgE reactivity to purified recombinant and native grass allergens. J. Allergy Clin. Immunol. 91, 339.
4. Bufe, A., Becker, W.M., Schramm, G., Petersen, A., Mamat, U., Schlaak, M., 1994. Major allergen Phl p Va (timothy grass) bears at least two different IgE-reactive epitopes. J. Allergy Clin. Immunol. 94, 173-181.
5. Bufe, A., Schramm, G., Keown, M.B., Schlaak, M., Becker, W.M., 1995. Major allergen Phl p Vb in timothy grass is a novel pollen RNase. FEBS Lett. 363, 6-12.
6. Cason, J., Patel, D., Naylor, J., Lunney, D., Sephard, P.S., Best, J.M., McCance, D.J., 1989. Identification of immunogenic regions of the major coat protein of human papillomavirus type 16 that contain type-restricted epitopes. J. Gen. Virol. 70, 2973-2987.
7. Elsayed, S., Apold, J., Holen, E., Vik, H., Florvaag, E., Dybendal, T., 1991. The structural requirements of epitopes with IgE binding capacity demonstrated by three major allergens from fish, egg and tree pollen. Scan. J. Clin. Lab. Invest. Suppl. 204, 17-31.
8. Esch, R.E., Klapper, D.G., 1989. Identification and localization of allergenic determinants on grass group I antigens using monoclonal antibodies. J. Immunol. 142, 179-184.
9. Ferreira, F., Rohlfs, A., Hoffmann-Sommergruber, K., Schenk, S., Ebner, C., Briza, P., Jilek, A., Kraft, D., Breitenbach, M., Scheiner, O., 1996. Modulation of IgE-binding properties of tree pollen allergens by site-directed mutagenesis. In (Eds) Sehon, HayGlass, Kraft, New Horizons in Allergy Immunotherapy. Plenum Press, New York. pp. 127-135.
10. Ford, S.A., Baldo, B.A., 1986. A re-examination of rye-grass (Lolium perenne) pollen allergens. Int. Arch. Allergy Appl. Immunol. 81, 193-203.
11. Gertzoff, E.D., Tainer, J.A., Lerner, R.A., Geysen, H.M., 1988. The chemistry and mechanism of antibody binding to protein antigens. Adv. Immunol. 43, 1-98.
12. Geysen, H.M., Meloen, R.H., Barteling, S.J., 1984. Use of a peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc. Natl. Acad. Sci. U.S.A. 81, 3998-4002.
13. Geysen, H.M., Rodda, S.J., Mason, T.J., Tribbick, G., Schoofs, P.G., 1987. Strategies for epitope analysis using peptide synthesis. J. Immunol. 102, 259-274.
14. Griffith, I.J., Smith, P.M., Pollock, J., Theerakulpisut, P., Avjioglu, A., Davies, S., Hough, T., Singh, M.B., Simpson, R.J., Ward, L.D., Knox, R.B., 1991. Cloning and sequencing of Lol p I, the major allergenic protein of rye-grass pollen. FEBS Lett. 279, 210-215.
15. Kawashima, T., Taniai, M., Usui, M., Ando, S., Kurimoto, M., Matuhasi, T., 1992. Antigenic analyses of Sugi basic protein by monoclonal antibodies: II. Detection of immunoreactive fragments in enzyme-cleaved Cry j I. Int. Arch. Allergy Immunol. 98, 118-126.
16. Knox, R.B., Suphioglu, C., 1996. Environmental and molecular biology of pollen allergens. Trends in Plant Science 1, 156-164.
17. Laver, W.G., Air, G.M., Webster, R.G., Smith-Gill, S.J., 1990. Epitopes on protein antigens: misconceptions and realities. Cell 61, 553-556.
18. Matthiesen, F., Lowenstein, H., 1991. Group V allergens in grass pollens II. Investigation of group V allergens in pollens from 10 grasses. Clin. Exp. Allergy 21, 309-320.
19. Ong, E.K., Griffith, I.J., Knox, R.B., Singh, M.B., 1993. Cloning of a cDNA encoding a group-V (group-IX) allergen isoform from rye-grass pollen that demonstrates specific antigenic immunoreactivity. Gene 134, 235-240.
20. Redlich, P.N., Hoeprich, P.D., Colby, C.B., Grossberg, S.E., 1991. Antibodies that neutralize human β interferon biological activity recognize a linear epitope: Analysis by synthetic peptide mapping. Proc. Natl. Acad. Sci. U.S.A. 88, 4040-4044.
21. Savoca, R., Schwab, C., Bosshard, H.R., 1991. Epitope mapping employing immobilised synthetic peptides. J. Immunol. Methods 141, 245-252.
22. Scheidtmann, K.H., 1990. Immunological detection of proteins of known sequence. In (Ed.) Creighton, T.E., Protein structure: a practical approach, p. 95. IRL Press, Oxford.
23. Silvanovich, A., Astwood, J., Zhang, L., Olsen, E., Kisil, F., Sehon, A., Mohapatra, S., Hill, R., 1991. Nucleotide sequence analysis of three cDNAs coding for Poa p IX isoallergens of Kentucky bluegrass pollen. J. Biol. Chem. 266, 1204-1210.
24. Singh, M.B., Hough, T., Theerakulpisut, P., Avjioglu, A., Davies, S., Smith, P.M., Taylor, P., Simpson, R.J., Ward, L.D., McCluskey, J., Puy, R., Knox, R.B., 1991. Isolation of cDNA encoding a newly identified major allergenic protein of rye-grass pollen: Intracellular targeting to the amyloplast. Proc. Natl. Acad. Sci. U.S.A. 88, 1384-1388.
25. Sithigorngul, P., Stretton, A.O.W., Cowden, C., 1991. A versatile dotELISA method with femtomole sensitivity for detecting small peptides. J. Immunol. Methods 141, 23-32.
26. Smith, A.M., Chapman, M.D., 1997. Localization of antigenic sites on Der p 2 using oligonucleotide-directed mutagenesis targeted to predicted surface residues. Clin. Exp. Allergy 27, 593-599.
27. Suphioglu, C., Singh, M.B., Simpson, R.J., Ward, L., Knox, R.B., 1993. Identification of canary grass (Phalaris aquatica) pollen allergens by immunoblotting: IgE and IgG antibody-binding studies. Allergy 48, 273-281.
28. Suphioglu, C., Singh, M.B., 1995. Cloning, sequencing and expression in E. coli of Pha a 1 and four isoforms of Pha a 5, the major allergens of canary grass pollen. Clin. Exp. Allergy 25, 853-865.
29. van Ree R., van Leeuwen, W.A., van den Berg, M., Weller, H.H., Aalberse, R.C., 1994. IgE and IgG cross-reactivity among Lol p I and Lol p II/III. Identification of the C-termini of Lol p I, II, and III as cross-reactive structures. Allergy 49, 254-261.
30. van Ree, R., Aalberse, R.C., 1995. Rabbit IgG directed to a synthetic C-terminal peptide of the major grass pollen allergen Lol p 1 inhibits human basophil histamine release induced by natural Lol p 1. Int. Arch. Allergy Immunol. 106, 250-257.
31. van Regenmortel, M.H.V., 1989. Structural and functional approaches to the study of protein antigenicity. Immunol. Today 10, 266-272.
32. Vik, H., Steinväg, S.K., Elsayed, S., 1993. Studies on the allergenicity of the amino-terminal epitope (Bet v I 23-38) from birch pollen allergen. Int. Arch. Allergy Immunol. 101, 89-94.
33. Xing, P.-X., Prenzoska, J., McKenzie, I.F.C., 1992. Epitope mapping of anti-breast and anti-ovarian mucin monoclonal antibodies. Mol. Immunol. 29, 641-650.