Localization of antigenic sites on Der p 2 using oligonucleotide- directed mutagenesis targeted to predicted surface residues

Clinical and Experimental Allergy

Volumn 27, Issue 5, 1997, Pages 593-599

  Smith, A M ^a   Chapman, M D ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

allergens; antigenic determinants; dust mites; IgE antibody; monoclonal antibody; mutagenesis; secondary structure

Indexed keywords

IMMUNOGLOBULIN E ANTIBODY; MONOCLONAL ANTIBODY;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; ANTIGENICITY; ARTICLE; DUST; HUMAN; HUMAN CELL; MITE; MUTAGENESIS; NONHUMAN; OLIGONUCLEOTIDE PROBE; PREDICTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

ANTIBODIES, MONOCLONAL; ANTIGENS, DERMATOPHAGOIDES; AUTOMATIC DATA PROCESSING; CLONING, MOLECULAR; EPITOPE MAPPING; GLYCOPROTEINS; IMMUNOGLOBULIN E; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROLINE; PROTEIN STRUCTURE, SECONDARY; RECOMBINATION, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 0030963219     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.1997.tb00750.x     Document Type: Article

References (27)

1. Benjamin DC, Berzofsky J, East I et al. The antigenic structure of proteins: A reappraisal. Ann Rev Immunol 1984; 2:67-101.
2. Davies D, Sheriff S, Padlan E. Antibody-antigen complexes. J Biol Chem 1988; 263:10541-4.
3. Benjamin DC. Molecular Approaches to the Study of B Cell Epitopes. Intern Rev Immunol 1991; 7:149-64.
4. Poljak RJ. Structures of antibodies and their complexes with antigens. Mol Immunol 1991; 28:1341-5.
5. Bossart-Whitaker P, Chang C-YY, Novotny J, Benjamin DC. Sheriff S. The crystal structure of the antibody N10-staphylococcal nuclease complex at 2.9 A resolution. J Mol Biol 1995; 253:559-75.
6. Smith AM, Woodward MP, Hershey CW, Hershey ED, Benjamin DC. The antigenic surface of staphylococcal nuclease. I. Mapping epitopes by site-directed mutagenesis. J Immunol 1991; 146:1254-8.
7. Smith AM, Benjamin DC. The antigenic surface of staphylococcal nuclease. II. Analysis of the N-I epitope by site-directed mutagenesis. J Immunol 1991; 146:1259-64.
8. Dudler T, Schneider T, Annand R, Gelb M, Suter M. Antigenic surface of the bee venom allergen phospholipase A2. J Immunol 1991; 152:5514-22.
9. Benjamin DC, Perdue SS. Site-directed mutagenesis in epitope mapping. Methods: A Companion to Methods in Enzymology 1996; 9:508-15.
10. Yuuki T, Okumura Y, Ando T, Yamakawa H, Sulo M, Haida M, Okudaira H. Cloning and expression of cDNA coding for the major house dust mite allergen. Der f II in Escherichia coli. Agric Biol Chem 1991; 55:1233-8.
11. Chua KY, Huang CH, Shen HD, Thomas WR. Analysis of sequence polymorphism of a major mite allergen, Der p 2. Clin Exp Allery 1996; 26:829-37.
12. Heymann PW, Chapman MD, Aalberse RC, Fox JW, Platts-Mills T. Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp.). J Allergy Clin Immunol 1989; 83:1055-67
13. Ovsyannikova I, Vailes LD, Li Y, Heymann PW, Chapman MD. Monoclonal antibodies to group II Dermatophagoides spp. allergens: Murine immune response, epitope analysis, and development of a two site ELISA. J Allery Clin Immunol 1994; 94:537-46.
14. Akagawa M, Mori T, Ando T, Okudaira H. Preparation of specific monoclonal antibodies against Der f II, one of the major allergens of Dermatophagoides farinae. Jpn J Allergol 1991; 40:1239-42.
15. Yaseuda H, Saito A, Yanagihara Y, Akiyama K, Takaoka M. Species-specific measurement of the second group of Dermatophagoides mite allergens. Der p 2 and Der f 2, using a monoclonal antibody-based ELISA. Clin Exp Allery 1996; 26:171-7.
16. Chua KY, Greene WK, Kehal P, Thomas WR. IgE binding studies with large peptides expressed from Der p II cDNA constructs. Clin Exp Allery 1991; 21:161-6.
17. van t'Hof W, Driedek PC, van den Berg M, Beck-Sickinger AG, Jung G, Aalberse RC. Epitope mapping of the Dermatophagoides pteronyssinus house dust mite major allergen Der p II using overlapping synthetic peptides. Mol Immunol 1991; 28:1225-32.
18. Nishiyama C, Yuuki T, Takai T, Okumura Y, Okudaira H. Dertermination of three disulfide bonds in a major house dust mite allergen Der f II essential for binding with human anti-mite IgE antibodies. Int Archs Allery Immunol 1993; 101:159-66.
19. Lombardero M, Heymann PW. Platts-Mills TAE, Fox JW, Chapman MD. Conformational stability of B cell epitopes on group I and group II Dermatophagoides spp. allergens: effect of thermal and chemical denaturation on the binding of murine IgG and human IgE antibodies. J Immunol 1990; 144:1353-60.
20. Smith AM, Chapman MD. Reduction in IgE binding to allergen variants generated by site-directed mutagenesis: contribution of disulfide bonds to the antigenic structure of the major house dust mite allergen Der p 2. Mol Immunol 1996; 33:399-405.
21. Huang MC, Seyer JM, Kang AH. Comparison and accuracy of methodologies employed for analysis of hydropathy, flexibility and secondary structure of proteins. J Immunol Meth 1990; 129:77-88.
22. Hopp T, Woods K. Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci USA 1981; 78:3824-8.
23. Karplus P, Schultz G. Prediction of chain flexibility in proteins. A tool for the selection of peptide antigens. Naturwissenschaften 1985; 72:212-3.
24. Chua KY, Doyle CR, Simpson RJ, Turner KJ. Stewart GA, Thomas WR. Isolation of cDNA coding for the major mite allergen Der p II by IgE plaque immunoassay. Int Archs Allery Appl Immunol 1990; 91:118-23.
25. Chou PY, Fasman GD. Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol 1978; 47:45-148.
26. Garnier J, Osguthorpe DJ, Robson B. Analysis of the accuracy and implications of a simple method for predicting the secondary structure of globular proteins. J Mol Biol 1978; 120:97-120.
27. Holley LH, Karplus M. Neural networks for protein structure prediction. Methods in Enzymology 1991; 202:204-24.