메뉴 건너뛰기




Volumn 94, Issue 3, 1998, Pages 431-437

Dose-dependent mechanisms relate to nasal tolerance induction and protection against experimental autoimmune encephalomyelitis in Lewis rats

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; IMMUNOLOGICAL TOLERANCE; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

EID: 0031818742     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1998.00526.x     Document Type: Article
Times cited : (26)

References (48)
  • 1
    • 0028202792 scopus 로고
    • Oral tolerence: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
    • WEINER H.L., FRIEDMAN A., MILLER A. et al. (1994) Oral tolerence: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 12, 809.
    • (1994) Annu Rev Immunol , vol.12 , pp. 809
    • Weiner, H.L.1    Friedman, A.2    Miller, A.3
  • 2
    • 0029965137 scopus 로고    scopus 로고
    • A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry
    • STEINMAN L. (1996) A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: A tale of smart bombs and the infantry. Proc Natl Acad Sci USA 93, 2253.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2253
    • Steinman, L.1
  • 3
    • 0030847054 scopus 로고    scopus 로고
    • Oral tolerance: Immune mechanisms and treatment of autoimmune diseases
    • WEINER H.L. (1997) Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today 18, 335.
    • (1997) Immunol Today , vol.18 , pp. 335
    • Weiner, H.L.1
  • 5
    • 0026042008 scopus 로고
    • Oral tolerance in experimental autoimmune encephalomyelitis HE Evidence for clonal anergy
    • WHITACRE C.C., GIENAPP I.E., OROSZ C.G. & BITMAR D.M. (1991) Oral tolerance in experimental autoimmune encephalomyelitis HE Evidence for clonal anergy. J Immunol 147, 2155.
    • (1991) J Immunol , vol.147 , pp. 2155
    • Whitacre, C.C.1    Gienapp, I.E.2    Orosz, C.G.3    Bitmar, D.M.4
  • 6
    • 0028358048 scopus 로고
    • Induction of anergy or active suppression following oral tolerance is determined by antigen dosage
    • FRIEDMAN A. & WEINER H.L. (1994) Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci USA 91, 6688.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6688
    • Friedman, A.1    Weiner, H.L.2
  • 7
    • 0029123992 scopus 로고
    • Exquisite peptide specificity of oral tolerance in experimental autoimmune encephalomyelitis
    • JAVED N.H., GIENAPP I.E., COX K.L. & WHITACRE C.C. (1995) Exquisite peptide specificity of oral tolerance in experimental autoimmune encephalomyelitis. J Immunol 155, 1599.
    • (1995) J Immunol , vol.155 , pp. 1599
    • Javed, N.H.1    Gienapp, I.E.2    Cox, K.L.3    Whitacre, C.C.4
  • 8
    • 0027538442 scopus 로고
    • Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin
    • MELAMED D. & FRIEDMAN A. (1993) Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin. Eur J Immunol 23, 935.
    • (1993) Eur J Immunol , vol.23 , pp. 935
    • Melamed, D.1    Friedman, A.2
  • 9
    • 0026046280 scopus 로고
    • Antigen-driven bystander suppression after oral administration of antigens
    • MILLER A., LIDER O. & WEINER H.L. (1991) Antigen-driven bystander suppression after oral administration of antigens. J Exp Med 174, 791.
    • (1991) J Exp Med , vol.174 , pp. 791
    • Miller, A.1    Lider, O.2    Weiner, H.L.3
  • 10
    • 0028288584 scopus 로고
    • Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals
    • MILLER A., LIDER O., ABRAMSKY O. & WEINER H.L. (1994) Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals. Eur J Immunol 24, 1026.
    • (1994) Eur J Immunol , vol.24 , pp. 1026
    • Miller, A.1    Lider, O.2    Abramsky, O.3    Weiner, H.L.4
  • 11
    • 0029962103 scopus 로고    scopus 로고
    • Antigen-specific immunotherapy of autoimmune disease: A commentary
    • WRAITH D.C. (1996) Antigen-specific immunotherapy of autoimmune disease: a commentary. Clin Exp Immunol 103, 349.
    • (1996) Clin Exp Immunol , vol.103 , pp. 349
    • Wraith, D.C.1
  • 12
    • 0030935905 scopus 로고    scopus 로고
    • Regulation of T cell function in mucosal tolerance
    • HOYNE G.F. & LAMB J.R. (1997) Regulation of T cell function in mucosal tolerance. Immunol Cell Biol 75, 197.
    • (1997) Immunol Cell Biol , vol.75 , pp. 197
    • Hoyne, G.F.1    Lamb, J.R.2
  • 13
    • 0027451437 scopus 로고
    • Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the Dominant T cell epitope in naive and sensitized mice
    • HOYNE G.F., O'HEHIR R.E., WRAITH D.C., THOMAS W.R. & LAMB J.R. (1993) Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the Dominant T cell epitope in naive and sensitized mice. J Exp Med 178, 1783.
    • (1993) J Exp Med , vol.178 , pp. 1783
    • Hoyne, G.F.1    O'Hehir, R.E.2    Wraith, D.C.3    Thomas, W.R.4    Lamb, J.R.5
  • 14
    • 0028019806 scopus 로고
    • Inhibition of T cell responses by feeding peptides containing major and cryptic epitopes. Studies with the Der pl allergen
    • HOYNE G.F., CALLOW M.G., KUO M.-C. & THOMAS W.R. (1994) Inhibition of T cell responses by feeding peptides containing major and cryptic epitopes. Studies with the Der pl allergen. Immunology 83, 190.
    • (1994) Immunology , vol.83 , pp. 190
    • Hoyne, G.F.1    Callow, M.G.2    Kuo, M.-C.3    Thomas, W.R.4
  • 15
    • 0030068998 scopus 로고    scopus 로고
    • Regulation of house dust mite responses by intranasally administered peptide: Transient activation of CD4+ T cells precedes the development of tolerance in vivo
    • HOYNE G.F., ASKONAS B.A., HETZEL C., THOMAS W.R. & LAMB J.R. (1996) Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo. Int Immunol 8, 335.
    • (1996) Int Immunol , vol.8 , pp. 335
    • Hoyne, G.F.1    Askonas, B.A.2    Hetzel, C.3    Thomas, W.R.4    Lamb, J.R.5
  • 16
    • 0027380361 scopus 로고
    • Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: Inhibition of MHC binding affinity
    • METZLER B. & WRAITH D.C. (1993) Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: inhibition of MHC binding affinity. Int Immunol 5, 1159.
    • (1993) Int Immunol , vol.5 , pp. 1159
    • Metzler, B.1    Wraith, D.C.2
  • 17
    • 0027467135 scopus 로고
    • Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uvcoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens
    • DICK A.D., CHENG Y.F., MCKINNON A., LIVERSIDGE J. & FORRESTER J.V. (1993) Nasal administration of retinal antigens suppresses the inflammatory response in experimental allergic uvcoretinitis. A preliminary report of intranasal induction of tolerance with retinal antigens. Br J Ophthalmol 77, 171.
    • (1993) Br J Ophthalmol , vol.77 , pp. 171
    • Dick, A.D.1    Cheng, Y.F.2    Mckinnon, A.3    Liversidge, J.4    Forrester, J.V.5
  • 18
    • 0028968686 scopus 로고
    • Suppression of experimental autoimmune mysathenia gravis by nasal administration of acctylcholine receptor
    • MA C.G., ZHANG G.X., XIAO B.G., LINK J., OLSSON T. & LINK H. (1995) Suppression of experimental autoimmune mysathenia gravis by nasal administration of acctylcholine receptor. J Neuroimmunol 58, 51.
    • (1995) J Neuroimmunol , vol.58 , pp. 51
    • Ma, C.G.1    Zhang, G.X.2    Xiao, B.G.3    Link, J.4    Olsson, T.5    Link, H.6
  • 19
    • 0029962104 scopus 로고    scopus 로고
    • Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184 of bovine type II collagen (CII) expressing a dominant T cell epilope
    • STAINES N.A., HARPER N., WARD F.J., MALMSTRÖM V., HOLMDAHL R. & BANSAL S. (1996) Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184 of bovine type II collagen (CII) expressing a dominant T cell epilope. Clin Exp Immunol 103, 368.
    • (1996) Clin Exp Immunol , vol.103 , pp. 368
    • Staines, N.A.1    Harper, N.2    Ward, F.J.3    Malmström, V.4    Holmdahl, R.5    Bansal, S.6
  • 20
    • 0029923430 scopus 로고    scopus 로고
    • Nasal administration of Glutamate Decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
    • TIAN J., ATKINSON M.A., CLARE-SALZLER M. et al. (1996) Nasal administration of Glutamate Decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med 183, 1561.
    • (1996) J Exp Med , vol.183 , pp. 1561
    • Tian, J.1    Atkinson, M.A.2    Clare-Salzler, M.3
  • 21
    • 0027169803 scopus 로고
    • + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production
    • + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J Exp Med 178, 889.
    • (1993) J Exp Med , vol.178 , pp. 889
    • Mcmenamin, C.1    Holt, P.G.2
  • 22
    • 0030456670 scopus 로고    scopus 로고
    • Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin-dependent diabetes
    • HARRISON L.C., DEMPSEY-COLLIER M., KRAMER D.R. & TAKAHASHI K. (1996) Aerosol insulin induces regulatory CD8 γδ T cells that prevent murine insulin-dependent diabetes. J Exp Med 184, 2167.
    • (1996) J Exp Med , vol.184 , pp. 2167
    • Harrison, L.C.1    Dempsey-Collier, M.2    Kramer, D.R.3    Takahashi, K.4
  • 23
    • 0029915770 scopus 로고    scopus 로고
    • Mucosal tolerance to experimental autoimmune myasthenia gravis is associated with down-regulation of AChR-specific IFN-γ-expressing Th1-like cells and up-regulation of TGF-β mRNA in mononuclear cells
    • MA C.-G., ZHANG G.-X., XIAO B.G. et al. (1996) Mucosal tolerance to experimental autoimmune myasthenia gravis is associated with down-regulation of AChR-specific IFN-γ-expressing Th1-like cells and up-regulation of TGF-β mRNA in mononuclear cells. Annu N Y Acad Sci 1996, 273.
    • (1996) Annu N Y Acad Sci , vol.1996 , pp. 273
    • Ma, C.-G.1    Zhang, G.-X.2    Xiao, B.G.3
  • 24
    • 0030578412 scopus 로고    scopus 로고
    • Antigen-driven peripheral immune tolerance: Suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic arthritis by aerosol administration of myelin basic protein or type II collagen
    • AL-SABBAGH A., NELSION P.A., AKSELBAND Y., SOBEL R.A. & WEINER H.L. (1996) Antigen-driven peripheral immune tolerance: Suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic arthritis by aerosol administration of myelin basic protein or type II collagen. Cell Immunol 171, 111.
    • (1996) Cell Immunol , vol.171 , pp. 111
    • Al-Sabbagh, A.1    Nelsion, P.A.2    Akselband, Y.3    Sobel, R.A.4    Weiner, H.L.5
  • 25
    • 0031469731 scopus 로고    scopus 로고
    • Nasal administration of myelin basic protein prevents relapsing experimental autoimmune encephalomyelitis in DA rats by activating regulatory cells expressing IL-4 and TGF-β mRNA
    • BAI X.F., SHI F.D., XIAO B.G., LI H.L., VAN DER MEIDE P.H. & LINK H. (1997) Nasal administration of myelin basic protein prevents relapsing experimental autoimmune encephalomyelitis in DA rats by activating regulatory cells expressing IL-4 and TGF-β mRNA. J Neuroimmunol 80, 65.
    • (1997) J Neuroimmunol , vol.80 , pp. 65
    • Bai, X.F.1    Shi, F.D.2    Xiao, B.G.3    Li, H.L.4    Van Der Meide, P.H.5    Link, H.6
  • 26
    • 0015264390 scopus 로고
    • Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species
    • DEIBLER G.E., MARTENSSON R.E. & KIES M.W. (1972) Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species. Prep Biochem 2, 139.
    • (1972) Prep Biochem , vol.2 , pp. 139
    • Deibler, G.E.1    Martensson, R.E.2    Kies, M.W.3
  • 27
    • 0019761904 scopus 로고
    • Production and assay of antibodies to acetylcholine receptors
    • LINDSTÖM J., EINARSON B. & TZARTOS S. (1981) Production and assay of antibodies to acetylcholine receptors. Meth Enzymol 74, 432.
    • (1981) Meth Enzymol , vol.74 , pp. 432
    • Lindstöm, J.1    Einarson, B.2    Tzartos, S.3
  • 28
    • 0026006328 scopus 로고
    • Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls
    • LINK H., OLSSON O., SUN J.-B. et al. (1991) Acetylcholine receptor-reactive T and B cells in myasthenia gravis and controls. J Clin Invest 87, 2191.
    • (1991) J Clin Invest , vol.87 , pp. 2191
    • Link, H.1    Olsson, O.2    Sun, J.-B.3
  • 29
    • 0027953227 scopus 로고
    • Organ-specific autoantigens induce transforming growth factor-β mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis
    • LINK J., FREDRIKSON S., SÖDERSTRÖM M. et al. (1994) Organ-specific autoantigens induce transforming growth factor-β mRNA expression in mononuclear cells in multiple sclerosis and myasthenia gravis. Ann Neurol 35, 197.
    • (1994) Ann Neurol , vol.35 , pp. 197
    • Link, J.1    Fredrikson, S.2    Söderström, M.3
  • 30
    • 0028169883 scopus 로고
    • Induction of IFN-γ, IL-4 and TGF-β in rats orally tolerized against experimental autoimmune myasthenia gravis
    • WANG Z.Y., LINK, H., LJUNGDAHL Å. et al. (1994) Induction of IFN-γ, IL-4 and TGF-β in rats orally tolerized against experimental autoimmune myasthenia gravis. Cell Immunol 157, 353.
    • (1994) Cell Immunol , vol.157 , pp. 353
    • Wang, Z.Y.1    Link, H.2    Ljungdahl, Å.3
  • 33
    • 0024474813 scopus 로고
    • Defence against allergic sensitization in the healthy lung: The role of inhalation tolerance
    • HOLT P.G. & MCMENAMIN C. (1989) Defence against allergic sensitization in the healthy lung: the role of inhalation tolerance. Clin Exp Allergy 19, 255.
    • (1989) Clin Exp Allergy , vol.19 , pp. 255
    • Holt, P.G.1    Mcmenamin, C.2
  • 34
    • 0030069688 scopus 로고    scopus 로고
    • Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9)
    • DANIEL D. & WEGMANN D.R. (1996) Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9). Proc Natl Acad Sci USA 93, 956.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 956
    • Daniel, D.1    Wegmann, D.R.2
  • 35
    • 0023927111 scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein
    • BITAR D.M. & WHITACRE C.C. (1988) Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein. Cell Immunol 112, 364.
    • (1988) Cell Immunol , vol.112 , pp. 364
    • Bitar, D.M.1    Whitacre, C.C.2
  • 36
    • 0023858086 scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments
    • HIGGINS P. & WEINER H.L. (1988) Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J Immunol 140, 440.
    • (1988) J Immunol , vol.140 , pp. 440
    • Higgins, P.1    Weiner, H.L.2
  • 37
    • 0024524088 scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes
    • LIDER O., SANTOS L.M.B., LEE C.S.Y., HIGGINS P.J. & WEINER H.L. (1989) Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes. J Immunol 142, 748.
    • (1989) J Immunol , vol.142 , pp. 748
    • Lider, O.1    Santos, L.M.B.2    Lee, C.S.Y.3    Higgins, P.J.4    Weiner, H.L.5
  • 38
    • 0027142439 scopus 로고
    • Epitopes of myelin basic protein that trigger TGF-β release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression
    • MILLER A., AL-SABBAGH A., SANTOS L.M.B., DAS M.P. & WEINER H.L. (1993) Epitopes of myelin basic protein that trigger TGF-β release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression. J Immunol 151, 7307.
    • (1993) J Immunol , vol.151 , pp. 7307
    • Miller, A.1    Al-Sabbagh, A.2    Santos, L.M.B.3    Das, M.P.4    Weiner, H.L.5
  • 39
    • 0026542168 scopus 로고
    • Suppressor T cell generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific trigerring
    • MILLER A., LIDER O., ROBERTS A.B., SPORN M.B. & WEINER H.L. (1992) Suppressor T cell generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific trigerring. Proc Natt Acad Sci USA 89, 421.
    • (1992) Proc Natt Acad Sci USA , vol.89 , pp. 421
    • Miller, A.1    Lider, O.2    Roberts, A.B.3    Sporn, M.B.4    Weiner, H.L.5
  • 40
    • 0026713026 scopus 로고
    • Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin F. expression in the brain
    • KHOURY S.J., HANCOCK W.W. & WEINER H.L. (1992) Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin F. expression in the brain. J Exp Med 176, 1355.
    • (1992) J Exp Med , vol.176 , pp. 1355
    • Khoury, S.J.1    Hancock, W.W.2    Weiner, H.L.3
  • 41
    • 0030069797 scopus 로고    scopus 로고
    • Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein
    • BROCKE S., GUBELS K., ALLEGRETTA M. et al. (1996) Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature 379, 343.
    • (1996) Nature , vol.379 , pp. 343
    • Brocke, S.1    Gubels, K.2    Allegretta, M.3
  • 42
    • 0028116618 scopus 로고
    • Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
    • RACKE M.K., BONOMO A., SCOTT D.E. et al. (1994) Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 180, 1961.
    • (1994) J Exp Med , vol.180 , pp. 1961
    • Racke, M.K.1    Bonomo, A.2    Scott, D.E.3
  • 43
    • 0343773445 scopus 로고    scopus 로고
    • IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
    • RÖCKEN M., RACKE M. & SHEVACH E.M. (1996) IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol Today 17, 255.
    • (1996) Immunol Today , vol.17 , pp. 255
    • Röcken, M.1    Racke, M.2    Shevach, E.M.3
  • 44
    • 0024436509 scopus 로고
    • Transforming growth factors b1 and b2: Cytokines with identical immnosuppressive effects and a potential role in the regulation of autoimmune T cell function
    • SCHLUESENER H.J. & LIDER O. (1989) Transforming growth factors b1 and b2: cytokines with identical immnosuppressive effects and a potential role in the regulation of autoimmune T cell function. J Neuroimmunol 24, 249.
    • (1989) J Neuroimmunol , vol.24 , pp. 249
    • Schluesener, H.J.1    Lider, O.2
  • 45
    • 0028982243 scopus 로고
    • TGF-β2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in viva
    • FABRY Z, TOPHAM D.J., FEE D. et al. (1995) TGF-β2 decreases migration of lymphocytes in vitro and homing of cells into the central nervous system in viva. J Immunol 155, 325.
    • (1995) J Immunol , vol.155 , pp. 325
    • Fabry, Z.1    Topham, D.J.2    Fee, D.3
  • 46
    • 0026707402 scopus 로고
    • Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
    • KENNEDY M.K., TORRANCE D.S., PICHA K.S. & MOHLER K.M. (1992) Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J Immunol 149, 2496.
    • (1992) J Immunol , vol.149 , pp. 2496
    • Kennedy, M.K.1    Torrance, D.S.2    Picha, K.S.3    Mohler, K.M.4
  • 47
    • 0028245010 scopus 로고
    • Interleukin-10 prevents experimental allergic encephalomyelitis in rats
    • ROTT O., FLEISCHER B. & CASH E. (1994) Interleukin-10 prevents experimental allergic encephalomyelitis in rats. Eur J Immunol 24, 1434.
    • (1994) Eur J Immunol , vol.24 , pp. 1434
    • Rott, O.1    Fleischer, B.2    Cash, E.3
  • 48
    • 0029742433 scopus 로고    scopus 로고
    • IL-10 fails to abrogate experimental autoimmune encephalomyelitis
    • CANNELA R., GAO Y.L., BROSNAN C. & RAINE C.S. (1996) IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J Neurosci Res 45, 735.
    • (1996) J Neurosci Res , vol.45 , pp. 735
    • Cannela, R.1    Gao, Y.L.2    Brosnan, C.3    Raine, C.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.