Anticoagulant effects of synthetic retinoids and activated vitamin D3

Seminars in Thrombosis and Hemostasis

Volumn 24, Issue 3, 1998, Pages 217-226

  Koyama, Takatoshi ^a   Hirosawa, Shinsaku ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Aging; Retinoic acid receptor (RAR); Synthetic retinoids; Thrombomodulin (TM); Tissue factor (TF)

Indexed keywords

3,5 DI TERT BUTYL 4' CHALCONECARBOXYLIC ACID; 4 [(5,6,7,8 TETRAHYDRO 5,5,8,8 TETRAMETHYL 2 NAPHTHYL)CARBOXAMIDO]BENZOIC ACID; ALITRETINOIN; CALCITRIOL; COLECALCIFEROL; ISOTRETINOIN; LE 540; RECEPTOR BLOCKING AGENT; RETINOIC ACID; RETINOIC ACID BINDING PROTEIN; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; RO 25 7386; RO 41 5253; RO 44 4753; RO 48 2249; TAMIBAROTENE; THROMBOMODULIN; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANTICOAGULATION; BINDING AFFINITY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; UMBILICAL VEIN;

EID: 0031818315     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-995845     Document Type: Conference Paper

References (26)

1. Tallman MS, Kwaan HC. Reassessing the hemostatic disorder associated with acute promyelocytic leukemia. Blood 1992;79: 543-553
2. Castaigne S, Chomienne C, Daniel MT, et al. All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia: I. Clinical results. Blood 1990;76:1704-1709
3. Weiler-Guettler H, Yu K, Soff G, Guds LJ, Rosenberg RD. Thrombomodulin gene regulation by cAMP and retinoic acid in F9 embryonal cells. Proc Natl Acad Sci USA 1992;89: 2155-2159.
4. Horie S, Kizaki K, Ishii H, Kazama M. Retinoic acid stimulates expression of thrombomodulin, a cell surface anticoagulant glycoprotein, on human endothelial cells. Biochem J 1992; 281:149-154
5. Lentz SR, Tsiang M, Sadler JE. Regulation of thrombomodulin by tumor necrosis factor-α: Comparison of transcriptional and post-transcriptional mechanisms. Blood 1991;77:542-550
6. Mackman N. Regulation of tissue factor gene. Thromb Haemostas 1997;78:747-754
7. Ishii H, Horie S, Kizaki K, Kazama M. Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor. Blood 1992;80:2556-2562
8. Koyama T, Hirosawa S, Kawamata N, Tohda S, Aoki N. All-trans retinoic acid (ATRA) upregulates thrombomodulin and downregulates tissue factor expression in acute promyelocytic leukemia cells: Distinct expression of thrombomodulin and tissue factor in human leukemic cells. Blood 1994;84:3001-3009
9. Saito T, Koyama T, Nagata K, Kamiyama R, Hirosawa S. Anticoagulant effects of retinoic acids on leukemia cells. Blood 1996; 87:657-665
10. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996;10:940-960
11. Shibakura M, Koyama T, Saito T, et al. Anticoagulant effects of synthetic retinoids mediated via different receptors on human leukemia and umbilical vein endothelial cells. Blood 1997;90:1545-1551
12. Shibakura M, Koyama T, Ohsawa M, Kamiyuma R, Hirosawa S. A retinoic acid receptor (RAR)-α selective agonist modulates procoagulant activity of acute promyelocytic cells and induces their differentiation into neutrophils. Blood 1998;91: 724-725
13. 3. Biochem J 1996;316:361-371.
14. 3 receptors. Cell 1991;65:1255-1266.
15. Tazawa R, Hirosawa S, Suzuki K, Hirokawa K, Aoki N. Functional characterization of the 5′-regulatory region of the human thrombomodulin gene. Biochem J 1993;113:600-606
16. Dittman WA, Nelson SC, Greer PK, et al. Characterization of thrombomodulin expression in response to retinoic acid and identification of a retinoic acid response element in the human thrombomodulin gene. J Biol Chem 1994;269:16925-16932
17. Schüle R, Rangarajan P, Yang N, et al. Retinoic acid is a negative regulator of AP-1 responsive genes. Proc Natl Acad Sci USA 1991;88:6092-6096
18. Tobita T, Takeshita A, Kitamura K, et al. Treatment with a new synthetic retinoid, Am80, of acute promyelocytic leukemia from complete remission induced by all-trans retinoic acid. Blood 1997;90:967-973
19. Barstad RM, Hamers MJAG, Stephens RW, Sakariassen S. Retinoic acid reduces induction of monocyte tissue factor and tissue factor/factor VIIa-dependent arterial thrombus formation. Blood 1995;86:212-218
20. Falanga A, Iacoviello L, Evangelista V, et al. Loss of blast cell procoagulant activity and improvement of hemostatic variables in patients with acute promyelocytic leukemia administered all-trans-retinoic acid. Blood 1995;86:1072-1081
21. 2 on human myelogenous leukemia cells and monocytes. Blood 1998; 92:in press.
22. 3, stimulates the production of prostacyclin by vascular tissues. Life Sci 1992;51: 1105-1112
23. Shudo K, Kagechika H. Structural evolution of retinoids. Adv Drug Res 1993;24:81-119
24. Apfel C, Bauer F, Crettaz M, et al. A retinoic acid receptor α antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci USA 1992;89:7129-7133
25. Kooistra T, Lansink M, Arts J, Sitter T, Toet K. Involvement of retinoic acid receptor α in the stimulation of tissue-type plasminogen activator gene expression in human endothelial cells. Eur J Biochem 1995;232:425-432
26. López-Boado YS, Klaus M, Dawson MI, López-Otín C. Retinoic acid-induced expression of apolipoprotein D and concomitant growth arrest in human breast cancer cells are mediated through a retinoic acid receptor RARα-dependent signaling pathway. J Biol Chem 1996;271:32105-32111.