Design and evaluation of new soft anticholinergic agents

Drug Development Research

Volumn 43, Issue 2, 1998, Pages 117-127

  Juhász, Attila ^a,b   Huang, Fenglei ^a   Ji, Fubao ^a   Buchwald, Peter ^a   Wu, Whei Mei ^a   Bodor, Nicholas ^a  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Drug design; Drug evaluation; Metabolism; Muscarinic antagonists

Indexed keywords

ATROPINE METHYL BROMIDE; CARBACHOL; CHOLINERGIC RECEPTOR BLOCKING AGENT; ETHOXYCARBONYLPHENYLCYCLOPENTYLACETOXY N,N DIMETHYLTROPINIUM METHYL SULFATE; HOMATROPINE METHYL BROMIDE; METHOXYCARBONYLPHENYLCYCLOPENTYLACETOXY N,N DIMETHYLTROPINIUM METHYL SULFATE; TEMATROPIUM; TROPICAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICHOLINERGIC EFFECT; ARTICLE; BRADYCARDIA; DRUG DESIGN; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MOLECULAR SIZE; MYDRIASIS; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RABBIT; RAT;

EID: 0031815677     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199802)43:2<117::AID-DDR5>3.3.CO;2-6     Document Type: Article

References (20)

1. Birkhimer LJ, Jacobson PA, Olson J, Goyette DM (1984): Ocular scopolamine induced psychosis. J Fam Prac 18(3):464-469.
2. Bodor N (1984): The soft drug approach. Chemtech 14(1):28-38.
3. Bodor N (1991): Soft drugs. In Dulbecco R (ed): Encyclopedia of Human Biology, 7. San Diego: Academic Press, Harcourt Brace Jovanovich Publishers, pp 101-117.
4. Bodor N, Buchwald P (1997): Molecular size based approach to estimate partition properties for organic solutes. J Phys Chem B 101(17):3404-3412.
5. Bodor N, Woods R, Raper C, Kearney P, Kaminski J (1980): Soft drugs. 3. A new class of anticholinergic agents. J Med Chem 23:474-480.
6. Bodor N, ElKoussi A, Hammer RH (1990): Soft drugs 9. The ultrashort duration of the muscarinolytic activity of a new short acting "soft" mydriatic agent. J Biopharm Sci 1(3):215-223.
7. Brouilette G, Kawamura M, Kumar GN, Bodor N (1996): Soft drugs 21. Design and evaluation of soft analogs of propantheline. Pharm Sci 85(6):619-623.
8. Brown JH, Palmer T (1996): Muscarinic receptor agonists and antagonists. In Goodman and Oilman (eds): The Pharmacological Basis of Therapeutics, Ninth Edition. McGraw-Hill pp 141-160.
9. 50) of an enzymatic reaction. Biochem Pharmacol 22:3099-3108.
10. Crowther GP, Kaizer EM, Woodruff RA, Hauser CR (1988): Esterification of hindered alcohols: terf-butylp-toluate. In Noland EW (ed): Organic Syntheses. Collective. Vol. 6. New York: John Wiley & Sons, pp 259-262.
11. Dewar MJS, Zoebisch EG, Healy EF, Stewart JJP (1985): AMI: A new general purpose quantum mechanical molecular model. J Am Chem Soc 107:3902-3909.
12. Hamborg PB, Neilsen MM, Thordal C (1984): Toxic effects of scopolamine eye drops in children. Acta Ophthalmol Scand 62(30):485-188.
13. Hammer RH, Amin K, Gumes E, Brouilette G, Bodor N (1988): Novel 'soft' anticholinergic agents. Drug Design Delivery 2:207-219.
14. Hammer RH, Wu W, Sastry JS, Bodor N (1991): Short acting soft mydriatics. Curr Eye Res 10(6):565-570.
15. Higgins CB, Vatner SF, Braunwald E (1973): Parasympathetic control of the heart. Pharmacol Rev 25(1):119-155.
16. Kumar GN, Bodor N (1996): Soft anticholinergics. Curr Med Chem 3:23-36.
17. Kumar GN, Hammer RH, Bodor N (1993): Soft drugs 12. Design, synthesis and evaluation of soft anticholinergics. Drug Des Discov 10:11-21.
18. Kumar GN, Huang MJ, Hammer RH, Bodor N (1994). Soft drugs 17. Quantitative structure-activity relationships of soft anticholinergics based on methatropine and methscopolamine. J Pharm Sci 83(1): 117-118.
19. Reiffers S, Wynberg H, Strating D (1971): α-Carboxylation of esters. Tetrahedron Lett 32:3001-3004.
20. Van Rossum JM, Hurkmans JH, Wolters CJ (1963): Cumulative dose response curves. Arch Int Pharmacodyn Ther 143:299-330.