Multiple endocrine neoplasia type 1 (MEN1): LOH studies in a affected family and in sporadic cases

Anticancer Research

Volumn 18, Issue 4 A, 1998, Pages 2685-2689

  Valdes, Nuria ^a   Alvarez, Victoria ^a   Diaz Cadorniga, Francisco ^a   Aller, Javier ^a   Villazon, Francisco ^a   Garcia, Isabel ^a   Herrero, Agustin ^a   Coto, Eliecer ^a  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

Author keywords

Linkage analysis; Loss of heterozygosity; Multiple endocrine neoplasia type 1 microsatellites; Single strand conformation polymorpnlsm

Indexed keywords

MICROSATELLITE DNA;

ADULT; ARTICLE; CHROMOSOME 11Q; CHROMOSOME DELETION; CLINICAL ARTICLE; CODON; DNA POLYMORPHISM; FAMILY STUDY; FEMALE; GASTRINOMA; HETEROZYGOSITY LOSS; HUMAN; MALE; MULTIPLE ENDOCRINE NEOPLASIA; PARATHYROID TUMOR; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ADOLESCENT; ADULT; CHROMOSOME DELETION; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 11; EXONS; FAMILY; FEMALE; GENES, TUMOR SUPPRESSOR; GENOTYPE; HOMOZYGOTE; HUMANS; LINKAGE (GENETICS); LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; PEDIGREE; POINT MUTATION; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 0031815621     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Wermer P: Genetic aspects of adenomatosis of endocrine glands. Am J Med 16: 363-367, 1954.
2. Backdahl M, Howe JR, Lairmore TC, Wells SA: The molecular biology of parathyroid disease. World J Surg 15: 756-762, 1991.
3. Pipeleers-Marichal M, Donow C, Heitz PU, Kloppel G: Pathologic aspects of gastrinomas in patients with Zollinger-Ellison syndrome with and without multiple endocrine neoplasia type 1. World J Surg 17: 481 - 488, 1993.
4. Trump D, Farren B, Wooding C, Pang JT, Besser GM, Buchanan KD, et al: Clinical studies of multiple endocrine neoplasis type 1 (Menl). Q J Med 89: 653-669, 1996.
5. Larsson K, Skogseid B, Öberg K, Nakamura Y, Nordenskjold M: Multiple endocrine neoplasia type 1 gene maps to chromososme 11 and is lost in insulinoma. Nature 332: 85-87, 1988.
6. Thakker RV, Bouloux P, Wooding D, Chotai K, Broad PM, Spurr NK, et al: Association of parathyroid tumors in multiple endocrine neoplasia type 1 with loss of alleles on chromosome 11. N Engl J Med 321: 218-224, 1989.
7. Bystrom C, Larsson C, Blomberg C, Sandelin K, Falkmer U, Skogseid B, et al: Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. Proc Natl Acad Sci USA 87: 1968-1972, 1990.
8. Friedman E, Sakaguchi K, Bale A E, Falchetti A, Streeten E, Zimering MV, et al: Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1. N Engl J Med 321: 213-218, 1989.
9. The European Consortium on Menl: Definition of the minimal MEN1 candidate area based on a 5 Mb integrated map of proximal 11q13. Genomics 37: 354-365, 1996.
10. Radford DM, Ashley SW, Wells SA, Gerhard DS: Loss of heterozygosity of markers on chromosome 11 in tumors from patients with multiple endocrine neoplasia syndrome type 1. Cancer Res 50: 6529 - 6533, 1990.
11. Knudson AG: Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68: 820 - 823, 1971.
12. Friedman E, De Marco L, Gejman PV, Norton JA, Bale AE, Aurbach GD, et al: Allelic loss from chromosome 11 in parathyroid tumors. Cancer Res 52: 6804 - 6809, 1992.
13. Thakker RV, Pook MA, Wooding C, Boscaro M, Scanarini M, Clayton RN: Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations. J Clin Invest 91: 2815 -2821, 1993.
14. Lubensky IA, Debelenko LV, Zhuang Z, Emmert-Buck MR, Dong Q, Chandrasekharappa S, et al: Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN 1 patients. Cancer Res 56: 5272-5278, 1996.
15. Bale AE, Norton JA, Wong EL, Fryburg JS, Maton PN, Oldfield EH, et at: Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1. Cancer Res 51: 1154-1157, 1991.
16. Chandrasekharappa SC, Guru SC, Olufemi SE, Collins FS, EmmertBuck MR, Debelenko LV, et al: Positional cloning of the gene for multiple endocrine neoplasia type 1. Science 276: 404-407, 1997.
17. The European Consortium on MEN1. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. Hum Mol Genet 6: 1177-1183, 1997.
18. Agarwal SK, Kester MB, Debelenko LV, Heppner C, Emmert- Buck MR, Skarulis MC, et at: Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. Hum Mol Genet 6: 1169-1175, 1997.
19. Gonzalez MV, Pello MF, Larrea CL, Suarez C, Menendez MJ, Coto E: Loss of heterozygosity and mutation analysis of the p16 (9p21) and p53 (17p13) genes in squamous cell carcinoma of the head and neck. Clin Cancer Res 1: 1043-1049, 1995.
20. Gonzalez MV, Artimez ML, Rodrigo L, Larrea CL, Menendez MJ, Alvarez V, et al: Mutation analysis of the p53, APC, and p16 genes in the Barrett's oesophagus, dysplasia, and adenocarcinoma. J Clin Pathol 50: 212-217, 1997.
21. Tanigami A, Tokino T, Takita K, Takiguchi S, Nakamura Y: A 14-Mb physical map of the region at chromosome 11q13 harboring the MEN1 locus and the tumor amplicon region. Genomics 13: 16-20, 1992.
22. Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Mellasseau P, et al: The 1993 - 94 Généthon human genetic linkage map. Nature Genet 7: 246 - 339, 1994.
23. Orita M, Suzuki Y, Sekiya T, Hayashi K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5: 874-879, 1989.
24. Beckers A, Abs R, Reyniers E, De Boulle K, Steavenaert A, Heller FR et al: Variable region of chromosome 11 loss in different pathological tissues of a patient with the multiple endocrine neoplasia type 1 syndrome. J Clin Endocrinol Metab 79: 1498 -1502, 1994.
25. Dong Q, Debelenko LV, Chandrasekharappa SC, Emmert-Buck MR, Zhuang Z, Guru SC et al: Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 82: 1416-1420, 1997.
26. Debelenko LV, Zhuang Z, Emmert-Buck MR, Chandrasekharappa SC, Manickam P, Guru SC et al: Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors. Cancer Res 57: 2238-2243, 1997.
27. Williamson C, Panett A, Pang JT, McCarthy M, Monson JP, Thakker RV: Localization of a tumor supressor gene causing parathyroid tumors to chormosome 1p34-1p36. J Bone Min Res 10 (Suppl 1): S154, 1995.
28. Stock JL, Warth MR, Teh BH, Coderre JA, Overdorf JH, Baumann G et al: A kindred with a variant of multiple endocrine neoplasia type 1 demonstrating frequent expression of pituitary tumors but not linked to the multiple endocrine neoplasia type 1 locus on chromosome region 11q13. J Clin Endocrinol Metab 82: 468-492, E1997.