The conventional transforming growth factor-β (TGF-β) receptor type I is not required for TGF-β1 signaling in a human prostate cancer cell line, LNCAP

Experimental Cell Research

Volumn 241, Issue 1, 1998, Pages 151-160

  Kim, Isaac Yi ^a,b   Zelner, David J ^a   Lee, Chung ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Prostate cancer; TGF ; TGF receptors; TGF signaling

Indexed keywords

ANDROSTANOLONE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; DRUG EFFECT; GROWTH REGULATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

EID: 0031815183     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4034     Document Type: Article

References (35)

1. Kingsley, D. M. (1994). The TGF-β superfamily: New members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8, 133-146.
2. Massague, J., Cheifetz, S., Laiho, M., Ralph, D. A., Weis, F. M. B., and Zentella, A. (1992). Transforming growth factor-β. Cancer Surv. 12, 81-103.
3. Wilding, G. (1991). Response of prostate cancer cells to peptide growth factor: Transforming growth factor-β. Cancer Surv. 11, 147-163.
4. Derynck, R. (1994). TGF-β-mediated signaling. Trends Biochem. Sci. 19, 548-553.
5. Lopez-Casillas, F., Cheifetz, S., Doody, J., Andres, J. L., Lane, W. S., and Massague, J. (1991). Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-β receptor. Cell 67, 785-795.
6. Lin, H. Y., Wang, X., Ng-Eaton, E., Weinberg, R. A., and Lodish, H. F. (1992). Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell 68, 775-785.
7. Franzen, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C., and Miyazono, K. (1993). Cloning of a TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor. Cell 75, 681-692.
8. Bassing, C. H., Yingling, J. M., Howe, D. J., Wang, T., He, W. W., Gustafson, M. L., Shah, P., Donahoe, P. K., and Wang, X.-F. (1994). A transforming growth factor β type I receptor that signals to activate gene expression. Science 263, 87-89.
9. Wrana, J. L., Attisano, L., Carcamo, J., Zentella, A., Doody, J., Laiho, M., Wang, X., and Massague, J. (1992). TGF-β signals through a heteromeric protein kinase receptor complex. Cell 71, 1003-1014.
10. Wrana, J. L., Attisano, L., Wieser, R., Ventura, F., and Massague, J. (1994). Mechanism of activation of the TGF-β receptor. Nature 370, 341-347.
11. ten Dijke, P., Yamashita, H., Ichijo, H., Franzen, P., Laiho, M., Miyazono, K., and Heldin, C.-H. (1994). A transforming growth factor β type I receptor that signals to activate gene expression. Science 264, 101-104.
12. ten Dijke, P., Ichijo, H., Franzen, P., Schulz, P., Saras, J., Toyoshoma, H., Heldin, C.-H., and Miyazono, K. (1993). Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene 8, 2879-2887.
13. Ebner, R., Chen, R.-H., Shum, L., Lawler, S., Zioncheck, T. F., Lee, A., Lopez, A. R., and Derynck, R. (1993). Cloning of a type I TGF-β receptor and its effect on TGF-β binding to the type II receptor. Science 260, 1344-1348.
14. Attisano, L., Carcamo, J., Ventura, F., Weis, F. M. B., Massague, J., and Wrana, J. (1993). Identification of human activin and TGF-β type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75, 671-681.
15. Horoszewicz, J. S., Leong, S. S., Kawinski, E., Karr, J. P., Rosenthal, H., Chu, M. T., Mirand, E. A., and Murphy, G. P. (1981). LNCaP model of human prostatic carcinoma. Cancer Res. 43, 1808-1817.
16. Wilding, G., Chen, M., and Gelman, E. (1989). Aberrant response in vitro of hormone-responsive prostate cancer cells to anti-androgens. Prostate 14, 103-115.
17. Kokontis, J., Kiyoshi, I., Hipakka, R. A., and Liao, S. (1991). Expression and function of normal and LNCaP androgen receptors in androgen-insensitive human prostatic cancer cells. Receptor 1, 271-279.
18. Sonnenschein, C., Olea, N., Pasanen, M. E., and Soto, A. M. (1989). Negative controls of cell proliferation: human prostate cancers and androgens. Cancer Res. 49, 3474-3481.
19. Lee, C., Sutkowski, D. M., Sensibar, J. A., Zelner, D., Kim, I., Amsel, I., Shaw, N., Prins, G. S., and Kozlowski, J. M. (1995). Regulation of proliferation and production of prostate specific antigen in androgen sensitive prostatic cancer cells, LNCaP, by dihydrotestosterone. Endocrinology 136, 796-803.
20. Kim, I. Y., Kim, J.-H., Zelner, D. J., Ahn, H.-J., Sensibar, J. A., and Lee, C. (1996). Transforming growth factor-β1 is a mediator of androgen-regulated growth arrest in an androgen-responsive prostatic cancer cell line, LNCaP. Endocrinology 137, 991-999.
21. Kim, I. Y., Zelner, D. J., Sensibar, J. A., Ahn, H.-J., Park, L., Kim, J.-H., and Lee, C. (1995). Modulation of sensitivity to transforming growth factor-β1 (TGF-β1) and the level of type II TGF-β receptor in LNCaP cells by dihydrotestosterone. Exp. Cell Res. 222, 103-110.
22. Schuurmans, A. L. G., Bolt, J., Veldscholte, J., and Mulder, E. (1991). Regulation of growth of LNCaP human prostate tumor cells by growth factors and steroid hormones. J. Steroid Biochem. Mol. Biol. 40, 193-197.
23. Kim, I. Y., Ahn, H.-J., Zelner, D. J., Shaw, J. W., Sensibar, J. A., Kim, J.-H., Kato, M., and Lee, C. (1996). Genetic change in transforming growth factor-β (TGF-β) receptor type I gene correlates with insensitivity to TGF-β1 in human prostate cancer cells. Cancer Res. 56, 44-48.
24. Siebert, P. D., and Larrick, J. W. (1992). Competitive PCR. Nature 359, 557-558.
25. Forster, E. (1994). Rapid generation of internal standards for competitive PCR by low-stringency primer annealing. Biotechniques 16, 1006-1008.
26. Steele, R. E. D., and Torrie, J. H. (1960) "Principles and Procedures of Statistics," McGraw-Hill, New York, NY.
27. Bouaboula, M., Legoux, P., Pessegue, B., Delpech, B., Dumont, X., Piechaczyk, M., Lasellas, P., and Shire, D. (1992). Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with multispecific internal control. J. Biol. Chem. 267, 21830-21838.
28. Ruberte, E., Marty, T., Nellen, D., Affolter, M., and Basler, K. (1995). An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo. Cell 80, 889-897.
29. Liu, F., Ventura, F., Doody, J., and Massague, J. (1995). Human type II receptor for bone morphogenic proteins (BMPs): Extension of the two kinase receptor model to the BMPs. Mol. Cell. Biol. 15, 3479-3486.
30. Wrana, J. L., Tran, H., Attisano, L., Arora, L., Childs, S. R., Massague, J., and O'Connor, M. B. (1994). Two distinct transmembrane serine/threonine kinases from drosophila melanogaster form an activin receptor complex. Mol. Cell. Biol. 14, 944-950.
31. Miettinen, P. J., Ebner, R., Lopez, A. R., and Derynck, R. (1994). TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors. J. Cell Biol. 127, 2021-2036.
32. Ito, M., Yasui, W., Kyo, E., Yokozaki, H., Nakayama, H., Ito, H., and Tahara, E. (1992). Growth inhibition of transforming growth factor β on human gastric carcinoma cells: Receptor and post-receptor signaling. Cancer Res. 52, 295-300.
33. Yamashita, H., ten Dijke, P., Franzen, P., Miyazono, K., and Heldin, C.-H. (1994). Formation of hetero-oligomeric complexes of type I and type II receptor for transforming growth factor-β. J. Biol. Chem. 269, 20172-2018.
34. Segarini, P. R., Rosen, D. M., and Seyedin, S. M. (1989). Binding of transforming growth factor-beta to cell surface proteins varies with cell type. Mol. Endocrinol. 3, 261-272.
35. Yamashita, H., Okadome, T., Franzen, P., ten Dijke, P., Heldin, C.-H., and Miyazono, K. (1995). A rat pituitary tumor cell line (GH3) expresses type I and type II receptors and other cell surface binding protein(s) for transforming growth factor-β. J. Biol. Chem. 270, 770-774.