Adhesion of mature polyploid megakaryocytes to fibronectin is mediated by β integrins and leads to cell damage

Experimental Cell Research

Volumn 242, Issue 1, 1998, Pages 315-327

  Berthier, Rolande ^a   Jacquier Sarlin, Muriel ^b   Schweitzer, Annie ^a   Block, Marc R ^b   Molla, Annie ^b  

^a INSERM   (France)

^b INSTITUT ALBERT BONNIOT   (France)

Author keywords

Cell adhesion; Fibronectin; Integrins; Megakaryocytes

Indexed keywords

FIBRONECTIN; INTEGRIN;

APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL DAMAGE; CELL SPREADING; CYTOSKELETON; GENE EXPRESSION; HUMAN; HUMAN CELL; MEGAKARYOCYTE; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STROMA CELL;

EID: 0031814615     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4119     Document Type: Article

References (37)

1. Adams, J. C. (1995). Formation of stable microspikes containing actin and the 55 Kda actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: Implication for the anti-adhesive activities of thrombospondin-1. J. Cell Sci. 108, 1977-1990.
2. Andrieux, A., Hudry-Clergeon, G., Ryckeweart, J-J., Chapel, A., Ginsberg, M. H., Plow, E. F., and Marguerie, G. (1989). Amino-acid sequences in fibrinogen mediating its interaction with its platelet receptor, GPIIbIIIa. J. Biol. Chem. 264, 9258-9265.
3. Berthier, R., Valiron, O., Schweitzer, A., and Marguerie, G. (1993). Serum-free medium allows the optimal growth of human plasma supplemented cultures: Role of TGFb. Stem Cells 11, 120-129.
4. Bruno, E., Briddell, R., and Hoffman, R. (1988). Effect of recombinant and purified hematopoietic growth factors on human megakaryocyte colony formation. Exp. Hematol. 16, 371-381.
5. Choi, E. S., Nichol, J. L., Hokom, M. M., Hornkohl, A. C., and Hunt, P. (1995). Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 85, 402-413.
6. Cordell, J. L., Falini, B., Erber, W. N., Ghosh, A. K., Abdulazis, Z., MacDonald, S., Pulford, K. A. F., Stein, H., and Mason, D. Y. (1984). Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase (APAAP complexes). J. Histochem. Cytochem. 32, 219-229.
7. Cui, L., Ramsfjell, V., Borge, O. J., Veiby, O. P., Lok, S., and Jacobsen, S. E. (1997). Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule-1: Role of activation of very late antigen (VLA)-4 and VLA-5. J. Immunol. 159, 1961-1969.
8. Delcommenne, M., and Streuli, C. H. (1995). Control of integrin expression by extracellular matrix. J. Biol. Chem. 270, 26794-26801.
9. Eaves, C. J., Cashman, J. D., Kay, R. J., Dougherty, G. J., Otsuka, T., Gaboury, L. A., Hogge, D. E., Lansdorp, P. M., Eaves, A. C., and Humphries, R. K. (1991). Mechanisms that regulate the cell status of very primitive hematopoietic cells in long term human marrow cultures. Blood 78, 110-117.
10. Fey, E. G., Wan, K. M., and Penman, S. (1984). Epithelial cytoskeletal framework and nuclear matrix-intermediate filament scaffold: Three-dimensional organization and protein composition. J. Cell Biol. 98, 1973-1984.
11. Gewirtz, A. M. (1995). Megakaryocytopoiesis: The state of the art. Thromb. Haemostasis 74, 204-209.
12. Hagiwara, T., Nagasawa, T., Nagahisa, H., Takizawa, M., Osada, M., and Abe, T. (1996). Expression of adhesion molecules on cytoplasmic processes of human megakaryocytes. Exp. Hematol. 24, 690-695.
13. Hotchin, N. A., and Hall, A. (1995). The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol. 131, 1857-1865.
14. Hynes, R. O. (1992). Integrins: Versatility, modulation, and signalling in cell adhesion. Cell 69, 11-25.
15. Klebe, R. J., Bentley, K. L., Sasser, P. J., and Schoen, R. C. (1980). Elution of fibronectin from collagen with chaotropic agents. Exp. Cell Res. 130, 111-117.
16. Klein, G., Beck, S., and Muller, C. A. (1993). Tenascin is a cytoadhesive extracellular matrix component of the human hematopoietic microenvironment. J. Cell Biol. 123, 1027-1035.
17. Leven, R. M. (1995). Differential regulation of integrin-mediated proplatelet formation and megakaryocyte spreading. J. Cell Physiol. 163, 597-607.
18. Maniotis, A. J., Chen, C. S., and Ingber, D. E. (1997). Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc. Natl. Acad. Sci. USA 94, 849-854.
19. Martin, P., and Papayannopoulou, T. (1982). HEL cells: A new human erythroleukemia cell line with spontaneous and induced globin expression. Science 216, 1232-1235.
20. Miltenyi, S., Müller, W., Weichel, W., and Rodburch, A. (1990). High gradient magnetic cell separation with MACS. Cytometry 11, 231-238.
21. Miyamoto, S. H., Akiyama, S. T., and Yamada, K. M. (1995). Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267, 883-885.
22. Molla, A., Berthier, R., Chapel, A., Schweitzer, A., and Andrieux, A. (1995). β1 integrins mediate adherent phenotype of human erythroblastic cell lines after phorbol 12-myristate 13-acetate induction. Biochem. J. 309, 491-497.
23. Mossuz, P., Schweitzer, A., Molla, A., and Berthier, R. (1997). Expression and function of receptors for extracellular matrix molecules in the differentiation of human megakaryocytes in vitro. Brit. J. Haematol. 98, 819-827.
24. Nagahisa, H., Nagata, Y., Ohnuki, T., Osada, M., Nagasawa, T., Abe, T., and Todokoro, K. (1996). Bone marrow stromal cells produce thrombopoietin and stimulate megakaryocyte growth and maturation but suppress proplatelet formation. Blood 87, 1309-1316.
25. Nagata, Y., Muro, Y., and Todokoro, K. (1997). Thrombopoietin-induced polyploidization of bone marrow megakaryocytes is due to a unique regulatory mechanism in late mitosis. J. Cell Biol. 139, 449-457.
26. Patel, V. P., and Lodish, H. F. (1992). The fibronectin receptor on mammalian erythroid precursor cells: Characterization and developmental regulation. J. Cell Biol. 102, 449-456.
27. Prieto, A. L., Andersson-Fisone, C., and Crossin, K. L. (1992). Characterization of multiple adhesive and counteradhesive domains in the extracellular matrix protein cytotactin. J. Cell Biol. 119, 663-678.
28. Schwartz, M. A., Schaller, M. D., and Ginsberg, M. H. (1995). Integrins: Emerging paradigms of signal transduction. Annu. Rev. Cell Dev. Biol. 11, 549-599.
29. Soligo, D., Schiro, R., Luksch, R., Manara, G., Quirici, N., Parravicini, C., and Lambertenghi Deliliers, G. (1990). Expression of integrins in human bone marrow. Br. J. Haematol. 76, 323-332.
30. Sugahara, H., Kanakura, Y., Furitsu, T., Ishihara, K., Oritani, K., Ikeda, H., Kitayama, H., Ishikawa, J., Hashimoto, K., Kanayama, Y., and Matsuzawa, Y. (1994). Induction of programmed cell death in human hematopoietic cell lines by fibronectin via its interaction with very late antigen 5. J. Exp. Med. 179, 1757-1766.
31. Symons, M., Derry, J. M. J., Karlak, B., Jiang, S., Lemahieu, V., McCormick Francke, U., and Abo, A. (1996). Wiskott-Aldrich syndrome protein, a novel effector for GTPase CDC42Hs, is implicated in actin polymerization. Cell 84, 723-734.
32. Vuillet-Gaugler, M. H., Breton-Gorius, J., Vainchenker, W., Guichard, J., Tchernia, G., and Colombel, L. (1990). Loss of attachment to fibronectin with terminal human erythroid differentiation. Blood 75, 865-873.
33. Wendling, F., Maraskovsky, E., Debili, N., Florindo, C., Teepe, M., Titeux, M., Methia, N., Breton-Gorius, J., Cosman, D., and Vainchenker, W. (1994). c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369, 571-574.
34. Whetton, A. D., and Dexter, T. M. (1993). Influence of growth factors and substrates on differentiation of hematopoietic stem cells. Curr. Opin. Cell Biol. 5, 1044-1049.
35. Wright, J. H. (1906). The origin and nature of blood platelets. Boston Med. Surg. J. 154, 643.
36. Zauli, G., Bassini, A., Vitale, M., Gibellini, D., Celeghini, C., Caramelli, E., Pierpaoli, S., Guidotti, L., and Capitani, S. (1997). Thrombopoietin enhances the alpha lib beta 3-dependent adhesion of megakaryocytic cells to fibrinogen or fibronectin through PI 3 kinase. Blood 89, 883-895.
37. Zauli, G., Vitale, M., Falcieri, E., Gibellini, D., Bassini, A., Celeghini, C., Columbaro, M., and Capitani, S. (1997). In vitro senescence and apoptotic cell death of human megakaryocytes. Blood 90, 2234-2243.