Effect of new thioacridine derivatives on P-gp function and on mdr1 gene expression

Anticancer Research

Volumn 18, Issue 4 C, 1998, Pages 3053-3058

  Hevér, Aniko ^a   Santelli Rouvier, Christiane ^b   Brouant, Pierre ^b   El Khyari, Said ^c   Molnár, Joseph ^a   Barra, Yves ^b   Barbe, Jacques ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b AIX MARSEILLE UNIVERSITY   (France)

^c FACULTÉ DES SCIENCES   (Morocco)

Author keywords

mdr1 gene; P glycoprotein; Thioacridines

Indexed keywords

2,7 DIMETHOXY 9 THIO (2' DIETHYLAMINOETHYL)ACRIDINONE; 3 AMINO 9 THIO (4' NITROBENZYL)ACRIDINONE; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; GLYCOPROTEIN P; RHODAMINE 123; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; T CELL LYMPHOMA;

ACRIDINES; ANIMALS; COLORING AGENTS; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION; HUMANS; LEUKEMIA, MYELOID, CHRONIC; LYMPHOMA, T-CELL; MICE; P-GLYCOPROTEIN; POLYMERASE CHAIN REACTION; RHODAMINE 123; RHODAMINES; RNA, NEOPLASM; TRANSCRIPTION, GENETIC;

EID: 0031813571     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Ueda K, Cornwell MM, Gottesman MM, Pastan I, Roninson IB, Ling V and Riordan JR: The mdr1 gene responsible for multidrug resistance codes for P-glycoprotein. Biochim Biophys Res commun 141: 956-962, 1986.
2. Roninson IB: The role of the mdr1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo Biochem Pharmacol 43: 95-102, 1992.
3. Gottesman MM and Pastan I: Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427, 1993.
4. Ford JM and Hait WN: Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacological Reviews 42: 155-1997 1990.
5. Zamora JM, Pearce HL and Beck WT: Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells. Mol Pharmacol 33: 454-462, 1988.
6. Tsuruo T, Iida H, Tsukagoshi S and Sakurai Y: Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 41: 1967-1972, 1981
7. Beck WT and Qian XD: Photoaffinity substrates for P-glycoprotein. Biochem Pharmacol 43: 89-93, 1992.
8. Safa AR: Photoaffinity labeling of P-glycoprotein in multidrug resistant cells. Cancer Inv 11(1): 46-56, 1993.
9. Muller C, Bailly JD, Goubin F, Laredo J, Jaffrezou JP, Bordier C and Laurent G: Verapamil decreases P-glycoprotein expression in multidrug resistant human leukemic cell lines. Int J Cancer 56: 794-754, 1994.
10. Muller C, Goubin F, Ferrandis E, Cornil-Scharwtz I, Bailly JD, Bordier C, Benard J, Sikic BI and Laurent G: Evidence for transcriptional control of human mdr1 gene expression by verapamil in multidrug-resistant leukemic cells. Mol Pharmacol 47: 51-56, 1995.
11. Herzog CE, Tsokos M, Bates SE and Fojo AT: Increased mdr-1/ P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists. J Biol Chem 268: 2946-2952, 1993.
12. Bhat UG, Winter MA, Pearce HL and Beck WT: A structure-function relationship among reserpine and yohimbine analogues in their ability to increase expression of mdr1 and P-glycoprotein in a human colon carcinoma cell line. Mol Pharmacol 48: 682-689, 1995.
13. Pastan I, Gottesman MM, Ueda K, Lovelace E, Rutherford AV and Willingham MC: A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells. Proc Natl Acad Sci USA 85: 4486-4490, 1988.
14. Tsuruo T, Lida-Saito H, Kawabata H, Oh-hara T, Hamada H and Utakoji T: Characteristics of resistance to adriamycin in human myelogenous leukemia K562 resistant to adriamycin and isolated clones. Jpn J Cancer Res 77: 682-692, 1986.
15. Lozzio CB and Lozzio BB: Human chronic myelogenous leukemia cell line with positive Philadelphia chromosome. Blood 45: 321-324, 1975.
16. Weaver JL, Szabo G, Pine PS, Gottesman MM, Goldenberg S and Aszalos A: The effect of ion channel blockers, immunosuppressive agents and other drugs on the activity of the multi-drug transporter. Int J Cancer 54: 456-461, 1993.
17. Chomczyinski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
18. Choudhary PM and Roninson IB: Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J Natl Cancer Inst 85: 632-639, 1993.