Models to predict drug metabolism

Manufacturing Chemist

Volumn 69, Issue 5, 1998, Pages 15-19

  Lewis, David ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450;

AMINO ACID SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; DRUG METABOLISM; ENZYME BINDING; ENZYME STRUCTURE; MOLECULAR MODEL; OXIDATION REDUCTION REACTION; SEQUENCE HOMOLOGY; SHORT SURVEY;

EID: 0031812180     PISSN: 02624230     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (10)

1. D.F.V. Lewis, 'Cytochromes P450: structure, function and mechanism', Taylor & Francis, London, 1996.
2. E.J. Mueller, P.J. Loida and S.G. Sligar in 'Cytochrome P450', ed P.R. Ortiz de Montellano, Plenum, New York, 1995.
3. T.L. Poulos, B.C. Finzel and A.J. Howard, J. Mol. Biol. 1987, 195, 687.
4. H. Li and T.L. Poulos, Nature Struc. Biol. 1997, 4, 140.
5. S. Rendic and F.J. Di Carlo, Drug Metabol. Rev. 1997, 29, 413.
6. D.A. Smith, M.J. Ackland and B.C. Jones, Drug Disc. Today 1997, 2, 406; 479.
7. D.F.V. Lewis and B.G. Lake, Toxicology, in press.
8. D.H. Williams et al. J. Am. Chem.Soc. 1991, 113, 7020.
9. H.-J. Bohm J. Computer-Aided Mol. Design, 1994, 8, 243.
10. D.F.V. Lewis and J.M. Pratt, Drug Metabol. Rev., in press.