Complexes between urokinase-type plasminogen activator and its receptor in blood as determined by enzyme-linked immunosorbent assay

International Journal of Cancer

Volumn 77, Issue 2, 1998, Pages 236-242

  De Witte, Hans ^a   Sweep, Fred ^a   Brünner, Nils ^b   Heuvel, Joop ^a   Beex, Louk ^a   Grebenschikov, Nicolai ^a   Benraad, Theo ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b FINSEN LABORATORY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

UROKINASE; UROKINASE RECEPTOR;

ADULT; AGED; ANTIBODY LABELING; ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; PRIORITY JOURNAL;

ADULT; AGED; BREAST NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MIDDLE AGED; RECEPTORS, CELL SURFACE; SENSITIVITY AND SPECIFICITY; URINARY PLASMINOGEN ACTIVATOR;

EID: 0031806811     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980717)77:2<236::AID-IJC12>3.0.CO;2-9     Document Type: Article

References (27)

1. ANDREASEN, P.A., KJØLLER, L., CHRISTENSEN, L. and DUFFY, M.J., The urokinase-type plasminogen activator system in cancer metastasis: a review. Int. J. Cancer, 72, 1-22 (1997).
2. BINNEMA, D.J., VAN IERSEL, J.J.L. and DOOIJEWAARD, G., Quantitation of urokinase antigen in plasma and culture media by use of an ELISA. Thrombosis Res., 43, 569-577 (1986).
3. CHAPMAN, H.A., Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration. Curr. Opinion Cell Biol., 9, 714-724 (1997).
4. CHEUNG, T., LUI, A.Y.Y. and LAU, H.K.F., Characterization of radioimmunoassays for high- and low-molecular weight urokinases and estimation of different forms of urokinase in urine and plasma. J. Lab. clin. Med., 121, 461-471 (1993).
5. DANØ, K., BEHRENDT, N., BRÜNNER, N., ELLIS, V., PLOUG, M. and PYKE, C., The urokinase receptor: protein structure and role in plasminogen activation and cancer invasion. Fibrinolysis, 8, (Suppl. 1), 189-203 (1994).
6. DE WITTE, H., PAPPOT, H., BRÜNNER, N., GRØNDAHL-HANSEN, J., HØYER-HANSEN, G., BEHRENDT, N., GULDHAMMER-SKOV, B., SWEEP, F., BENRAAD, T. and DANØ, K., ELISA for complexes between urokinase-type plasminogen activator and its receptor in lung cancer tissue extracts. Int. J. Cancer, 72, 416-423 (1997).
7. GOODSON, R.J., DOYLE, M.V., KAUFMAN, S.E. and ROSENBERG, S., High-affinity urokinase receptor antagonists identified with bacteriophage peptide display. Proc. nat. Acad. Sci. (Wash.), 91, 7129-7133 (1994).
8. GREBENSCHIKOV, N., GEURTS-MOESPOT, A., DE WITTE, H., HEUVEL, J., LEAKE, R., SWEEP, F. and BENRAAD, T., A sensitive and robust assay for urokinase and tissue-type plasminogen activators (uPA and tPA) and their inhibitor type I (PAI-1) in breast tumor cytosols. Int. J. biol. Markers, 12, 6-14 (1997).
9. GRØNDAHL-HANSEN, J., AGERLIN, N., MUNKHOLM-LARSEN, P., BACH, F., NIELSEN, L.S., DOMBERNOWSKY, P. and DANØ, K., Sensitive and specific enzyme-linked immunosorbent assay for urokinase-type plasminogen activator and its application to plasma from patients with breast cancer. J. Lab. clin. Med., 111, 42-51 (1988).
10. HØYER-HANSEN, G., PLOUG, M., BEHRENDT, N., RØNNE, E. and DANØ, K., Cell-surface acceleration of urokinase-catalyzed receptor cleavage. Europ. J. Cancer, 243, 21-26 (1997).
11. r 52,000 plasminogen activating enzyme. Proc. nat. Acad. Sci. (Wash.), 79, 3720-3723 (1982).
12. KOHSE, K.P. and WISSER, H., Antibodies as a source of analytical errors. J. clin. Chem. clin. Biochem., 28, 881-892 (1990).
13. LAU, H.K.F., TEITEL, J.M., CHEUNG, T., KUNG, S.K.P. and GARVEY, M.B., Hypofibrinolysis in patients with hypercoagulability: the roles of urokinase and plasminogen activator inhibitor. Amer. J. Hematol., 44, 260-265 (1993).
14. MIZUKAMI, I.F., FAULKNER, N.E., GYETKO, M.R., SITRIN, R.G. and TODD, R.F., III, Enzyme-linked immunosorbent assay detection of a soluble form of urokinase plasminogen activator receptor in vivo. Blood, 86, 203-211 (1995).
15. PAPPOT, H., HØYER-HANSEN, G., RØNNE, E., HANSEN, H.H., BRÜNNER, N., DANØ, K. and GRØNDAHL-HANSEN, J., Elevated plasma levels of urokinase plasminogen activator receptor in non-small cell lung cancer patients. Europ. J. Cancer, 33, 867-872 (1997).
16. PEDERSEN, N., SCHMITT, M., RØNNE, E., NICOLETTI, M.I., HØYER-HANSEN, G., CONESE, M., GIAVAZZI, R., DANØ, K., KUHN, W., JÄNICKE, F. and BLASI, F., A ligand-free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer. J. clin. Invest., 92, 2160-2167 (1993).
17. PLOUG, M., ELLIS, V. and DANø, K., Ligand interaction between urokinase-type plasminogen activator and its inhibitor probed with 8-anilino-1-naphtalenesulfonate; evidence for a hydrophobic binding site exposed only on the intact receptor. Biochemistry, 33, 8991-8997 (1994).
18. PLOUG, M., ERIKSEN, J., PLESNER, T., HANSEN, N.E. and DANØO, K., A soluble form of the glycolipid-anchored receptor for urokinase-type plasminogen activator is secreted from peripheral blood leukocytes from patients with paroxysmal nocturnal hemoglobinuria. Europ. J. Biochem., 208, 397-404 (1992).
19. 2-terminal domain of the urokinase receptor. FEBS Lett., 288, 233-236 (1991).
20. RØNNE, E., HØYER-HANSEN, G., BRÜNNER, N., PEDERSEN, H., RANK, F., OSBORNE, C.K., CLARK, G.M., DANØ, K. and GRØNDAHL-HANSEN, J., Urokinase receptor in breast cancer tissue extracts; enzyme-linked immunosorbent assay with a combination of mono- and polyclonal antibodies. Breast Cancer Res. Treat., 33, 199-207 (1995a).
21. RØNNE, E., PAPPOT, H., GRØNDAHL-HANSEN, J., HØYER-HANSEN, G. and PLESNER, T., The receptor for urokinase plasminogen activator is present in plasma from healthy donors and elevated in patients with paroxysmal nocturnal hemoglobinuria. Brit. J. Haematol., 89, 576-581 (1995b).
22. ROSENQUIST, C., THORPE, S.M., DANØ, K. and GRØNDAHL-HANSEN, J., Enzyme-linked immunosorbent assay of urokinase-type plasminogen activator (uPA) in cytosolic extracts of human breast cancer tissue. Breast Cancer Res. Treat., 28, 223-229 (1993).
23. SCHMITT, M., HARBECK, N., THOMSSEN, C., WILHELM, O., MAGDOLEN, V., REUNING, U., ULM, K., HÖFLER, H., JÄNICKE, F. and GRAEFF, H., Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapy. Thrombosis Haemostasis, 78, 285-296 (1997).
24. SCHULMAN, M., WILDE, C.D. and KÖHLER, G.A., A better cell line for making hybridomus secreting specific antibodies. Nature (Lond.), 275, 269-270 (1978).
25. STEPHENS, R.W., PEDERSEN, A.N., NIELSEN, H.J., HAMERS, M.J.A.G., HØYER-HANSEN, G., RØNNE, E., DYBKJæR, E, DANØ, K. and BRÜNNER, N., ELISA determination of soluble urokinase receptor in blood from healthy donors and cancer patients. Clin. Chew., 43, 1868-1876 (1997).
26. WEI, Y., WALTZ, D.A., RAO, N., DRUMMOND, R.J., ROSENBERG, S. and CHAPMAN, H.A., Identification of the urokinase receptor as an adhesion receptor for vitronectin. J. biol. Chem., 269, 32380-32388 (1994).
27. WUN, T.-C., SCHLEUNING, W.-D. and REICH, E., Isolation and characterization of urokinase from human plasma. J. biol. Chem., 257, 3276-3283 (1982).