Interaction of retinoblastoma protein and D cyclins during cell-growth inhibition by hexamethylenebisacetamide in TM2H mouse epithelial cells

Molecular Carcinogenesis

Volumn 22, Issue 2, 1998, Pages 128-143

  Said, Thenaa K ^a   Medina, Daniel ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cell cycle; D cyclins; Hexamethylenebisacetamide; Retinoblastoma protein

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; DIFFERENTIATION INDUCING FACTOR; DNA; HEXAMETHYLENEBISACETAMIDE; PROTEIN P16; PROTEIN P27; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ARTICLE; BREAST EPITHELIUM; BREAST HYPERPLASIA; CELL CYCLE G1 PHASE; CELL GROWTH; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; EPITHELIUM CELL; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE EPITHELIUM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ACETAMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; EPITHELIAL CELLS; FLOW CYTOMETRY; GENES, RETINOBLASTOMA; HUMANS; HYPERPLASIA; MALE; MAMMARY GLANDS, ANIMAL; MICE; MICROTUBULE-ASSOCIATED PROTEINS; PROSTATE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEINS;

EID: 0031806630     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199806)22:2<128::AID-MC8>3.0.CO;2-I     Document Type: Article

References (66)

1. Sherr CJ. Mammalian G1 cyclins. Cell 73:1059-1065, 1993.
2. Hunter T, Pines J. Cyclins and cancer. II: Cyclin D and cdk inhibitors come of age. Cell 79:573-582, 1994.
3. Pardee AB. G1 events and regulation of cell proliferation. Science 246:603-609, 1989.
4. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65:701-713, 1991.
5. Kiyokawa H, Busquets X, Powell CT, Ngo L, Rifkind RA, Marks PA. Cloning of a D-type cyclin from murine erythroleukemia cells. Proc Natl Acad Sci USA 89:2444-2447, 1992.
6. Won K-A, Xiong Y, Beach D, Gilman MZ. Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. Proc Natl Acad Sci USA 89:9910-9914, 1992.
7. Inaba T, Matsushime H, Valentine M, Roussel MF, Sherr CJ, Look AT. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics 13:565-574, 1992.
8. Xiong Y, Menninger J, Beach D, Ward DC. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics 13:575-584, 1992.
9. Peters G. The D-type cyclins and their role in tumorigenesis. J Cell Sci Suppl 18:89-96, 1994.
10. Motokura T, Bloom T, Kim HJ, et al. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350:512-515, 1991.
11. Lammie GA, Peters G. Chromosome 11q13 abnormalities in human cancer. Cancer Cells 3:413-420, 1991.
12. Fantl V, Smith R, Brookes S, Dickson C, Peters G. Chromosome 11q13 abnormalities in human breast cancer. Cancer Surv 18:77-94, 1993.
13. Hall FL, Williams RT, Wu L, et al. Two potentially oncogenic cyclins, cyclin A and D1, share common properties of subunit configuration, tyrosine phosphorylation, and physical association with the RB protein. Oncogene 8:1377-1384, 1993.
14. Meyerson M, Harlow ED. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol 14:2077-2086, 1994.
15. Bates S, Bonetta L, MacAllan D, et al. CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene 9:71-79, 1994.
16. Xiong Y, Zhang H, Beach D. D-type cyclins associate with multiple protein kinases and DNA replication and repair factor PCNA. Cell 1:505-514, 1992.
17. Hunter T. Braking the cycle. Cell 75:839-841, 1993.
18. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704, 1993.
19. Musgrove EA, Lilischkis R, Cornish AL, et al. Expression of the cyclin-dependent kinase inhibitors p16INK4, p15INK4B, and p21WAF1/CIP1 in human breast cancer. Int J Cancer 63:584-591, 1995.
20. Serrano M, Hannon GJ, Beach DA. New regulatory motif in cell-cycle control causing specific inhibition of cyclin D/cdk4. Nature 366:704-707, 1993.
21. Lukas J, Parry D, Aagaard L, et al. Retinoblastoma-protein-dependent cell-cycle inhibition by the tumor suppressor p16. Nature 375:503-506, 1995.
22. Rusin MR, Okamoto A, Chorazy M, et al. Intragenic mutations of the p16(INK4), p15(INK4B), and p18 genes in primary non-small cell lung cancers. Int J Cancer 65:734-739, 1996.
23. INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature 371:257-261, 1994.
24. Reynisdottir I, Polyak K, Iavarone A, Massague J. Kip/Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev 9:1831-1845, 1995.
25. kip1, a cyclin-cdk inhibitor, links transforming growth factor β and contact inhibition to cell cycle arrest. Genes Dev 8:9-22, 1994.
26. Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J 10:4279-4290, 1991.
27. Lin BT-Y, Gruenwald S, Morla AO, Lee W-H, Wang JYJ. Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase. EMBO J 10:857-864, 1991.
28. Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70:993-1006, 1992.
29. Hu Q, Lees JA, Buchkovich KJ, Harlow E. The retinoblastoma protein physically associates with the human cdc2 kinase. Mol Cell Biol 12:971-980, 1992.
30. Lukas J, Bartkova J, Rohde M, Strauss M, Bartek I. Cyclin D1 is dispensible for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. Mol Cell Biol 15:2600-2611, 1995.
31. Reshitzky D, Reed SI. Different roles for cyclin D1 and E in regulation of the G1-to-S transition. Mol Cell Biol 15:3463-3469, 1995.
32. Connell-Crowley L, Harper WJ, Goodrich DW. Cyclin D1/cdk4 regulate retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell 8:287-301, 1997.
33. Dowdy SF, Hinds PW, Louie K, et al. Physical interactions of the retinoblastoma protein with human D-cyclins. Cell 73:499-511, 1993.
34. Ewen ME, Siuss HK, Sherr CJ, Matsushime H, Kato H-Y, Livingston DM. Functional interaction of the retinoblastoma protein with mammalian D-type cyctins. Cell 73:487-497, 1993.
35. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 81:323-336, 1995.
36. Bartek J, Bantkova J, Lukas J. The retinoblastoma protein pathway and the restriction point. Curr Opin Cell Biol 8:805-814, 1996.
37. Dyson N. pRb, p107, and regulation of the E2F transcription factor. J Cell Sci Suppl 18:81-87, 1994.
38. Buckley MF, Sweeney KJ, Hamilton JA, et al. Expression and amplification of cyclin genes in human breast cancer. Oncogene 8:2127-2133, 1993.
39. Lukas J, Bartkova J, Welcker M, et al. Cyclin D2 is a moderately oscillating nucleoprotein required for G1 phase progression in specific cell types. Oncogene 10:2125-2134, 1995.
40. Musgrove EA, Lee CS, Buckley MF, Sutherland RL. Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle. Proc Natl Acad Sci USA 91:8022-8026, 1994.
41. Lukas J, Müller H, Bartkova J, et al. DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1. J Cell Biol 125:625-638, 1994.
42. Han EK, Sgambato A, Jiang W, et al. Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth. Oncogene 10:953-961, 1995.
43. Said TK, Luo L, Medina D. Mouse mammary hyperplasias and neoplasias exhibit different patterns of cyclin D1 and D2 binding to cdk4. Carcinogenesis 16:2507-2513, 1995.
44. Rifkind RA, Richon VM, Marks PA. Induced differentiation, the cell cycle, and the treatment of cancer. Pharmacol Ther 69:97-102, 1996.
45. Marks PA, Richon VA, Kiyokawa H, Rifkind RA. Induced differentiation of transformed cells with hybrid polar compounds: A cell cycle-dependent process. Proc Natl Acad Sci USA 91:10251-10254, 1994.
46. Li XN, Du ZW, Huang Q. Modulation effects of hexamethylene bisacetamide on growth and differentiation of cultured human malignant glioma cells. J Neurosurg 84:831-838, 1996.
47. Nakamura T, Okuyama S, Okamoto S, Nakajima T, Sekiya S, Oda K. Down-regulation of the cyclin A promoter in differentiating human embryonal carcinoma cells is mediated by depletion of ATF-1 and ATF-2 in the complex at the ATF/CRE site. Exp Cell Res 216:422-430, 1995.
48. Kiyokawa H, Richon VM, Rifkind RA, Marks PA. Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells. Mol Cell Biol 14:7195-7203, 1994.
49. Cobrinik D, Dowdy SF, Hinds PW, Mittnacht S, Weinberg RA. The retinoblastoma protein and the regulation of cell cycling. Trends Biochem Sci 17:312-315, 1992.
50. Marks PA, Breslow R, Rifkind RA, Ngo L, Singh R. Polar/apolar chemical inducers of differentiation of transformed cells: Strategies to improve therapeutic potential. Proc Natl Acad Sci USA 86:6358-6362, 1989.
51. Breslow R, Jursic B, Fa Yan Z, et al. Potent cytodifferentiating agent related to hexamethylenebisacetamide. Proc Natl Acad Sci USA 88:5542-5546, 1991.
52. Medina D, Kittrell FS, Oborn CJ, Schwartz M. Growth factor dependency and gene expression in preneoplastic mouse mammary epithelial cells. Cancer Res 53:668-674, 1993.
53. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival: Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 89:271-277, 1986.
54. Said TK, Medina D. Cell cyclins and cyclin-dependent kinase activities in mouse mammary tumor development. Carcinogenesis 16:823-830, 1995.
55. Sherr CJ. Cancer cell cyclins. Science 274:1672-1677, 1996.
56. Richon VA, Rifkind RA, Marks PA. Expression and phosphorylation of the retinoblastoma protein during induced differentiation of murine erythroleukemia cells. Cell Growth Differ 3:413-420, 1992.
57. Keane MM, Lowrey GA, Ettenberg SA, Dayton MA, Lipkowitz S. The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells. Cancer Res 56:4236-4243, 1996.
58. Hunter T, Toyoshima H. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21. Cell 78:67-74, 1994.
59. Wang QM, Luo X, Studzinski GP. Cyclin-dependent kinase 6 is the principal target of p27/kip1 regulation of the G1-phase traverse in 1,25-dihydroxyvitamin 03-treated HL60 cells. Cancer Res 57:2851-2855, 1997.
60. Wakasugi E, Kobayashi T, Tannaka Y, et al. Analysis of phosphorylation of pRb and its regulatory proteins in breast cancer. J Clin Pathol 50:407-512, 1997.
61. Mittnacht S, Lees JA, Desai D, Harlow E, Morgan DO, Weinberg RA. Distinct subpopulations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J 13:118-127, 1994.
62. Mittnacht S, Weinberg RA. G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment. Cell 65:381-393, 1991.
63. Ezhevsky SA, Nagahara H, Vocero-Akbani AM, Gius DR, Wei MC, Dowdy SF. Hypophosphorylation of the retinoblastoma protein (pRb) by cyclin D:cdk4/6 complexes results in active pRb. Proc Natl Acad Sci USA 94:10699-10704, 1997.
64. Sicinski P, Donaher JL, Parker SB, et al. Cyclin D1 provides link between development and oncogenesis in the retina and breast. Cell 82:621-630, 1995.
65. Sicinski P, Donaher JL, Geng Y, et al. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 384:470-474, 1996.
66. Watanabe T, Kume T, Oishi M. Alteration of phosphotyrosine-containing proteins at the early stage of erythroid differentiation of mouse erythroleukemia (MEL) cells. J Biol Chem 267:17116-17120, 1992.