Galaninergic signalling and adenylate cyclase

Neuropeptides

Volumn 32, Issue 3, 1998, Pages 197-210

  Karelson, E ^a   Langel, U ^b  

^a UNIVERSITY OF TARTU   (Estonia)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENYLATE CYCLASE; AMINO ACID; ASPARTIC ACID; CALCIUM CHANNEL; CALCIUM ION; CORTICOTROPIN; CYCLIC AMP; GALANIN; GALANIN DERIVATIVE; GALANIN RECEPTOR; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; HISTAMINE; INSULIN; NEUROPEPTIDE Y; NEUROTRANSMITTER; NORADRENALIN; PEPTIDE; POTASSIUM CHANNEL; POTASSIUM ION; SEROTONIN; SUBSTANCE P;

ADENOHYPOPHYSIS; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENDOCRINE SYSTEM; ENTORHINAL CORTEX; ENZYME ACTIVITY; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; INSULIN RELEASE; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; STRUCTURE ACTIVITY RELATION;

EID: 0031803664     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0143-4179(98)90038-5     Document Type: Review

References (127)

1. Tatemoto K, Rökaeus Å, Jörnvall H, McDonald T J, Mutt V. Galanin, a novel biologically active peptide from porcine intestine. FEBS Lett 1983; 164: 124-128.
2. Skofitch G, Jacobowitz D M. Quantitative distribution of galanin-like immunoreactivity in the rat central nervous system. Peptides 1986; 7: 609-613.
3. Bartfai T, Hökfelt H, Langel U. Galanin - a neuroendocrine peptide. Crit Rev Neurobiol 1993; 7: 229-274.
4. Kask K, Langel U, Bartfai T. Galanin - a neuropeptide with inhibitory actions. Cell Mol Neurobiol 1995; 15: 653-673.
5. Fisone G, Wu C F, Consolo S et al. Galanin inhibits acetylcholine release in the ventral hippocampus of the rat: histochemical, autoradiographic, in vivo and vitro studies. Proc Natl Acad Sci USA 1987; 84: 7339-7343.
6. Fisone G, Bartfai T, Nilsson S, Hökfelt T. Galanin inhibits the potassium-evoked release of acetylcholine and the muscarinic receptor-mediated stimulation of phosphoinositide turnover in slices of monkey hippocampus. Brain Res 1991; 568: 279-284.
7. Ögren S O, Kehr J, Schott P A. Effects of ventral hippocampal galanin on spatial learning and on vivo acetylcholine release in the rat. Neuroscience 1996; 75: 1127-1140.
8. Seutin V, Verbanck P, Massotte L, Dresse A. Galanin decreases the activity of locus coeruleus neurons in vitro. Eur J Pharmacol 1989; 164: 373-374.
9. Sevcik J, Finta E P, Illes P. Galanin receptors inhibit the spontaneous firing of locus coeruleus neurones and interact with mu-opioid receptors. Eur J Pharmacol 1993; 230: 223-230.
10. 3H] 5-hydroxytryptamine from rat hypothalamic synaptosomal preparations. Neurosci Lett 1991; 122: 87-90.
11. Nordström Ö, Melander T, Hökfelt T, Bartfai T, Goldstein M. Evidence for an inhibitory effect of the peptide galanin on dopamine release from the rat median eminence. Neurosci Lett 1987; 73: 21-26.
12. Melander T, Hökfelt T, Rökaeus Å et al. Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS. J Neurosci 1986; 6: 3640-3654.
13. Kahl U, Bartfai T. Galanin receptors. Drug News & Perspectives 1995; 8: 404-410.
14. McDonald T J, Dupre J, Tatemoto K, Greenberg G R, Radziuk J, Mutt V. Galanin inhibits insulin secretion and induces hyperglycaemia in dogs. Diabetes 1985; 34: 192-196.
15. Hermansen K. Effects of galanin on the release of insulin, glucagon and somatostatin from the isolated, perfused dog pancreas. Acta Endocrinol (Copenh) 1988; 119: 91-98.
16. Ahrén B, Lindskog S. Galanin and the regulation of islet hormone secretion. Int J Pancreatol 1992; 3: 147-160.
17. Cremagnani L, Vaccari M, Maronati E et al. Potentiating effect of galanin on GHRH-induced GH release. Comparison between old and young subjects. Horm Metab Res 1996; 28: 101-104.
18. Koshiyama H, Shimatsu A, Kato Y et al. Galanin-induced prolactin release in rats: pharmacological evidence for the involvement of α-adrenergic and opioidergic mechanism. Brain Res 1990; 507: 321-324.
19. Grottoli S, Arvat E, Gianotti L et al. Galanin positively modulates prolactin secretion in normal women. J Endocrinol Invest 1996; 19: 739-744.
20. Wiesenfeld-Hallin Z, Xu, X J, Langel U, Bedecs K, Hökfelt T, Bartfai T. Galanin-mediated control of pain: enhanced role after nerve injury. Proc Natl Acad Sci USA 1992; 89: 3334-3337.
21. Botella A, Delvaux M, Frexinos J, Bueno L. Comparative effects of galanin on isolated smooth muscle cells from ileum in five mammalian species. Life Sci 1992; 50: 1253-1261.
22. Bauer F E. Galanin: ein neues biologisch aktives gastrointestinales Neuropeptid. Z Gastroenterol 1990; 28: 160-169.
23. Crawley J, Austin M, Fiske S M et al Activity of centrally administered galanin fragments on stimulation of feeding behaviour and on galanin receptor binding in the rat hypothalamus. J Neurosci 1990; 10: 3695-3700.
24. Leibowitz S F, Kim T. Impact of a galanin antagonist on exogenous galanin and natural patterns of fat digestion. Brain Res 1992; 599: 148-152.
25. Kask K, Berthold M, Bartfai T. Galanin receptors: involvement in feeding, pain, depression and Alzheimer's disease. Life Sci 1997; 60: 1523-1533.
26. Cheung C C, Clifton D K, Steiner R A. Galanin. An unassuming neuropeptide moves to center stage in reproduction. Trends Endocrinol Metab 1996; 7: 301-306.
27. Aminaroff B, Lorinet A M, Laburthe M. Galanin receptor in the rat pancreatic beta cell line Rin m5F. Molecular characterization by chemical cross-linking. J Biol Chem 1989; 264: 20714-20717
28. Fisone G, Langel Ü, Carlquist M et al. Galanin receptor and its ligands in the rat hippocampus. Eur J Biochem 1989; 181: 269-276.
29. Amiranoff B, Chen Y H, Lorinet A M, Covineau A, Laburthe M. Galanin receptors in endocrine pancreas and brain - functional and molecular characterization. Biomed Res 1992; 13: 319-323.
30. Gu Z F, Pradhan T K, Coy D H, Jensen R T. Galanin-induced relaxation in gastric smooth muscle cells is mediated by cyclic AMP. Peptides 1994; 15: 1425-1430.
31. Gu Z F, Pradhan T K, Coy D H, Jensen R T. Smooth muscle cells from guinea pig stomach possess high-affinity galanin receptors that mediate relaxation. Am J Physiol 1994; 266: G839-G845.
32. + channel in the beta-cell? Peptides 1989; 10: 453-457.
33. + channels. Eur J Pharmacol 1994; 255: 25-32.
34. 2+ channels. J Neurochem 1991; 56: 739-747
35. 2+ current in the Rin m5F cell line. Proc Natl Acad USA 1991; 88: 8744-8748.
36. Fridolf T, Ahrén B. Dual action of the neuropeptide galanin on the cytoplasmic free calcium concentration in RIN m5F Cells. Biochem Biophys Res. Commun 1993; 191: 1224-1229.
37. Aminaroff B, Lorinet A M, Lagny-Pourmir I, Laburthe M. Mechanism of galanin-inhibited insulin release. Occurrence of a pertussis-toxin-sensitive inhibition of adenylate cyclase. Eur J Biochem 1988; 177: 147-152.
38. Chen Y, Laburthe M, Amiranoff B. Galanin inhibits adenylate cyclase of rat brain membranes. Peptides 1992; 13: 339-341.
39. Valkna A, Juréus A, Karelson E, Zilmer M, Bartfai T, Langel Ü. Differential regulation of adenylate cyclase activity in rat ventral and dorsal hippocampus by rat galanin. Neurosci Lett 1995; 187: 75-78.
40. Taussig R, Gilman A G. Mammalian membrane-bound adenylyl cyclases. J Biol Chem 1995; 270: 1-4.
41. Zhang G, Liu Y, Ruoho A E, Hurley J H. Structure of the adenylyl cyclase catalytic core. Nature 1997; 386: 247-253.
42. Hanoune J, Fouille Y, Tzavara E et al. Adenylyl cyclases: structure, regulation and function in an enzyme superfamily. Mol Cell Endocrinol 1997; 128: 179-194.
43. Hously M D, Milligan G. Tailoring cAMP-signalling responses through isoform multiplicity. TIBS 1997; 22: 217-224.
44. sα with the cytosolic domains of mammalian-adenylyl cyclase. J Biol Chem 1997; 272: 22265-22271.
45. 2+-sensitive adenylyl cyclases. Cellular Signalling 1994; 6: 823-840.
46. Drews G, Debuyser A, Henquin J-E. Significance of membrane repolarization and cyclic AMP changes in mouse pancreatic B-cells for the inhibition of insulin release by galanin. Mol Cell Endocrinol 1994; 105: 97-102.
47. Sharp GWG. Mechanisms of inhibition of insulin release. Am J Physiol-Cell Physiol 1996; 40: C1781-C1789.
48. Renström E, Ding W-G, Bokvist K, Rorsman P. Neurotransmitter-induced inhibition of exocytosis in insulin-secreting β-cells by activation of calcineurin. Neuron 1996; 17: 513-522.
49. Lindskog S, Ahrén B. Studies on the mechanism by which galanin inhibits insulin secretion in islets. Eur J Pharmacol 1991; 205: 21-27.
50. Amiranoff B, Lorinet A M, Laburthe M. A clonal rat pancreatic δ cell line (Rin 14B) expresses a high number of galanin receptor negatively coupled to a pertussis-toxin-sensitive cAMP-production pathway. Eur J Biochem 1991; 195: 459-463.
51. Parker E M, Izzarelli D G, Nowak H P et al. Cloning and characterization of the rat GALR1 galanin receptor from Rin 14B insulinoma cells. Mol Brain Res 1995; 34: 179-189.
52. Cormont M, Le Marchand-Brustel Y, Van Obberghen E, Spiegel, A M, Sharp GWG. Identification of G-protein α-subunits in RIN m5F cells and their selective interaction with galanin receptor. Diabetes 1991; 40: 1170-1176.
53. Gillison S L, Sharp G W. ADP ribosylation by cholera toxin identifies three G-proteins that are activated by the galanin receptor. Studies with RINm5F cell membranes. Diabetes 1994; 43: 24-32.
54. 0 proteins functionally coupling galanin receptors to voltage-gated calcium channels. EMBO J 1995; 14: 4728-4737
55. i3 proteins mediate the inhibition of adenylyl cyclase by galanin in the RINm5F cell. Diabetes 1995; 44: 453-459.
56. i3. Biochem J 1994; 303: 369-375.
57. Gregersen S, Hermansen K, Langel U, Fisone G, Bartfai T, Ahrén B. Galanin-induced inhibition of insulin secretion from rat islets: effects of rat and pig galanin and galanin fragments and analogues. Eur J Pharmacol 1991; 203: 111-114.
58. Lagny-Pourmir I, Lorinet A M, Yanaihara N, Laburthe M. Structural requirements for galanin interaction with receptors from pancreatic beta cells and from brain tissue of the rat. Peptides 1989; 10: 757-761.
59. Amiranoff B, Lorinet A M, Yanaihara N, Laburthe M. Structural requirement for galanin action in the pancreatic beta cell line Rin m 5F. Eur J Pharmacol 1989; 163: 205-207
60. Gallwitz B, Schmidt W E, Schwarzhoff R, Creutzfeldt W. Galanin: structural requirements for binding and signal transduction in RINm5F insulinoma cells. Biochem Biophys Res Commun. 1990; 172: 268-275.
61. Fehmann H-C, Janssen M, Göke B. Interaction of glucagon-like peptide (GLP-I) and galanin in insulin (βTC-1)- and somatostatin (RIN T3)-secreting cells and evidence that both peptides. Acta Diabet 1995; 32: 176-181.
62. Wang Z-L, Kulkarni R N, Wang R-M et al. Possible evidence for endogenous production of a novel galanin-like peptide. J Clin Invest 1997; 100: 189-196.
63. Juréus A, Langel U. Galanin and galanin antagonists. Acta Chimica Slovenica 1996; 43: 51-60.
64. Gregersen S, Lindskog S, Land T, Langel Ü, Bartfai T, Ahrén B. Blockade of galanin-induced inhibition of insulin secretion from isolated mouse islets by the non-methionine containing antagonist - M35. Eur J Pharmacol 1993; 232: 35-39.
65. Kask K, Berthold M, Bourne J, Andell S, Langel U, Bartfai T. Binding and agonist/antagonist actions of M35, galanin (1-13)-bradykmin (2-9)amide chimeric peptide, in Rin m5F insulinoma cells. Regul Pept 1995; 59: 341-348.
66. Yanaihara N, Mochizuki T, Takatsuka N et al. Galanin analogues: agonist and antagonist. Regul Pept 1993; 46: 93-101.
67. Kakuyama H, Mochizuki, T, Iguchi K et al. [Ala(6), D-Trp(8)]galanin(1-15)-ol is a potent galanin antagonist on insulin release. Biomed Res (Tokyo) 1997; 18: 49-56.
68. Melander T, Hökfelt T, Rökaeus A. Distribution of galanin-like immunoreactivity in the rat central nervous system. J Comp Neurol 1986; 248: 475-517.
69. 125I-galanin binding sites in the rat central nervous system. J Chem Neuroanat 1988; 1: 213-233.
70. Kordower J H, Le H K, Mufson E J. Galanin immunoreactivity in the primate central nervous system. J Comp Neurol 1992; 319: 479-500.
71. Bedecs K, Berthold M, Bartfai T. Galanin - 10 years with neuroendocrine peptide. Int J Biochem Cell Biol 1995; 27: 337-349.
72. Crawley J N. Galanin-acetylcholine interactions: relevance to memory and Alzheimer's disease. Life Sci 1996; 58: 2185-2199.
73. Wynick D, Smith D M, Ghatei et al. Characterisation of a high-affinity galanin receptor in the rat anterior pituitary. Proc Natl Acad Sci USA 1993; 90: 4231-4235.
74. Karelson E, Laasik J, Sillard R. Regulation of adenylate cyclase by galanin, neuropeptide Y, secretin and vasoactive intestinal peptide in rat frontal cortex, hippocampus and hypothalamus. Neuropeptides 1995; 28: 21-28.
75. 1A receptor coupling to adenylyl cyclase in discrete regions of the rat brain. Eur J Pharmacol 1994; 269: 209-217.
76. Chartrel N, Wang Y, Fournier A, Vaudry H, Conlon J M. Frog vasoactive intestinal polypeptide and galanin: primary structures and effects on pituitary adenylate cyclase. Endocrinology 1995; 136: 3079-3086.
77. Hooi S C, Maiter D M, Martin J B, Koeing J I. Galaninergic mechanisms are involved in the regulation of corticotropin and thyrotropin secretion in the rat. Endocrinology 1990; 127: 2281-2289.
78. Goldstein M, Deutch A Y. The inhibitory actions of NPY and galanin on H-3-norepinephrine release in the central nervous system - relation to a proposed hierarchy of neuronal coexistence. In: Mutt V, Hökfelt T, Fuxe K, Lundberg J M, eds. Neuropeptide Y. Karolinska Institute Nobel Conference Series No. 14. New York: Raven Press, 1989: 153-162.
79. Arrang J M, Gulat-Marnay C, Defontaine N, Schwartz J C. Regulation of histamine release in rat hypothalamus and hippocampus by presynaptic galanin receptors. Peptides 1991; 12: 1113-1117.
80. Zini S, Roisin M P, Langel U, Bartfai T, Ben-Ari Y. Galanin reduces release of endogenous excitatory amino acids in the rat hippocampus. Eur J Pharmacol Mol Pharmacol 1993; 245: 1-7
81. Nishibori M, Oishi R, Itoh Y, Saeki K. Galanin inhibits noradrenaline-induced accumulation of cyclic AMP in the rat cerebral cortex. J Neurochem 1988; 51: 1953-1955.
82. Pieribone V A, Xu Z, Grillner S, Bartfai T, Hökfelt T. Galanin induces a hyperpolarization of norepinephrine containing locus coeruleus neurons in the brainstem slice. Neuroscience 1995; 64: 861-874.
83. Fuxe K, Ögren S-O, Jannson A, Cintra A, Harfstrand A, Agnati L F. Intraventricular injection of galanin reduces 5-HT metabolism in the ventral limbic cortex, the hippocampal formation and fronto-parietal cortex of the male rat. Acta Physiol Scand 1988; 133: 579-581.
84. Davis T M, Burrin J M, Bloom S R. Growth hormone (GH) release in response to GH-releasing hormone in man is 3-fold enhanced by galanin. J Clin Endocrinol Metab 1987; 65: 1248-1252.
85. Howard A D, Tan C, Shiao L-L et al. Molecular cloning and characterization of a new receptor of galanin. FEBS Lett 1997; 405: 285-290.
86. Fisone G, Berthold M, Bedecs K et al. N-terminal galanin-(1-16) fragment is an agonist at the hippocampal galanin receptor. Proc Natl Acad Sci USA 1989; 86: 9588-9591.
87. Girotti P, Bertorelli R, Fisone G et al. N-terminal galanin fragments inhibit the hippocampal release of acetylcholine in vivo. Brain Res 1993; 612: 258-262
88. 1A receptors in the dorsal hippocampus of the rat brain: possible existence of galanin receptor subtypes. Brain Res 1994; 634: 163-167.
89. Hedlund P B, Yanaihara N, Fuxe K. Evidence for specific N-terminal galanin fragment binding sites in the rat brain. Eur J Pharmacol 1992; 224: 203-205.
90. Ögren S-O, Hökfelt T, Kask K, Langel U, Bartfai T. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience 1992; 51: 1-5.
91. Pramanik A, Ögren S-O. Galanin stimulates striatal acetylcholine release via a mechanism unrelated to cholinergic receptor stimulation. Regul Pept 1993; 45: 353-362.
92. Chen Y H, Couvineau A, Laburthe M, Aminaroff B. Solubilization and molecular characterization of active galanin receptors from rat brain. Biochemistry 1992; 31: 2415-2422
93. Chen Y H, Fournier A, Couvineau A, Laburthe M, Aminaroff B. Purification of a galanin receptor from pig brain. Proc Natl Acad Sci USA 1993; 90: 3845-3849.
94. Land T, Langel U, Bartfai T. Hypothalamic degradation of galanin(1-29) and galanin(1-16): identification and characterization of the peptidolytic products. Brain Res 1991; 558: 245-250.
95. Langel U, Land T, Bartfai T. Design of chimeric peptide ligands to galanin receptors and substance P receptors. Int J Pept Protein Res 1992; 39: 516-522.
96. 125I]galantide. J Pharmacol Exp Ther 1995; 275: 720-727.
97. Bartfai T, Bedecs K, Land T et al. M-15: high-affinity chimeric peptide that blocks the neuronal actions of galanin in the hippocampus, locus coeruleus, and spinal cord. Proc Natl Acad Sci USA 1991; 88: 10961-10965.
98. Pramanik A, Ögren S-O. Galanin evoked acetylcholine release in the rat striatum is blocked by the putative galanin antagonist M15. Brain Res 1992; 574: 317-319.
99. Gabriel S M, Rivkin A, Mercado J Jr. The galanin antagonist, M-15, inhibits growth hormone release in rats. Peptides 1993; 14: 633-636.
100. Sahu A, Xu B, Kalra S P. Role of galanin in stimulation of pituitary luteinizing hormone secretion as revealed by a specific receptor antagonist, galantide. Endocrinology 1994; 134: 529-536.
101. Bartfai T, Fisone G, Langel U. Galanin and galanin antagonists: molecular and biochemical perspectives. TIPS 1992; 13: 312-317.
102. Xu X J, Wiesenfeld-Hallin Z, Langel U, Bedecs K, Bartfai T. New high affinity peptide antagonists to the spinal galanin receptor. Br J Pharmacol 1995; 116: 2076-2080.
103. Crawley J N, Robinson J, Langel U, Bartfai T. Galanin receptor antagonists M 40 and C 7 block galanin-induced feeding. Brain Res 1993; 600: 268-272.
104. Bartfai T, Langel Ü, Bedecs K et al. Galanin-receptor ligand M40 peptide distinguishes between putative galanin-receptor subtypes. Proc Natl Acad Sci USA 1993; 90: 11287-11291.
105. Corwin R L, Robinson J K, Langel U, Bartfai T, Crawley J N. Galanin antagonists M40, C7, and M32, microinjected into the PVN of the hypothalamus, block galanin-induced feeding in rats. Soc Neurosci Abstr 1992; 18: 1427.
106. Ögren S-O, Pramanik A, Land T, Langel U. Differential effects of the putative galanin receptor antagonists M15 and M35 on striatal acetylcholine release. Eur J Pharmacol 1993; 242: 59-64.
107. Valkna A, Laidmäe E, Karelson E, Zilmer M, Juréus A, Langel Ü. Effects of chimeric galanin receptor ligands on basal adenylate cyclase activity in rat ventral hippocampal membranes. Protein Peptide Lett 1995; 2: 267-274.
108. Sheriff S, Balasubramaniam A. Inhibitory and stimulatory effects of neuropeptide Y (17-36) on rat cardiac adenylate cyclase activity. J Biol Chem 1992; 267: 4680-4685.
109. Grady T, Fickova M, Tager HS, Trivedi D, Hruby V J. Stimulation and inhibition of cAMP accumulation by glucagon in canine hepatocytes. J Biol Chem 1987; 262: 15514-15520.
110. Magnaldo I, Pouyssegur J, Paris S. Thrombin exerts a dual effect on stimulated adenylate cyclase in hamster fibroblasts, an inhibition via a GTP-binding protein and a potentiation via activation of protein kinase C. Biochem J 1988; 253: 711-719.
111. Järv J, Toomela T, Karelson E. Dual effect of carbachol on the muscarinic receptor. Biochem Mol Biol Int 1993; 30: 649-654.
112. Rossowski WJ, Rossowski T M, Zacharia S, Ertan A, Coy D H. Galanin binding sites in rat gastric and jejunal smooth muscle membrane preparation. Peptides 1990; 11: 333-338.
113. Juréus A, Langel U, Bartfai T. L-Ala-substituted rat galanin analogs distinguish between hypothalamic and jejunal galanin receptor subtypes. J Pept Res 1997; 49: 195-200.
114. Gu Z F, Pradhan T K, Coy D H, Jensen R T. Interaction of galanin fragments with galanin receptors on isolated smooth muscle cells from guinea pig stomach: identification of a novel galanin receptor subtype. J Pharmacol Exp Ther 1995; 272: 371-378.
115. Howard A D, Tan C, Shiao L-L, et al. Molecular cloning and characterization of a new receptor for galanin. FEBS Lett 1997; 405: 285-290.
116. Gu Z F, Rossowski W J, Coy D H, Pradhan T K, Jensen R T. Chimeric galanin analogs that function as antagonists in the CNS are full agonists in gastrointestinal smooth muscle. J Pharmacol Exp Ther 1993; 266: 912-918.
117. Lorimer D D, Benya R V. Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract. Biochem Biophys Res Commun 1996; 222: 379-385.
118. Habert-Ortoli E, Amiranoff B, Loquet I, Laburthe M, Mayaux J-F. Molecular cloning of a functional human galanin receptor. Proc Natl Acad Sci USA 1994; 91: 9780-9783.
119. Burgevin M-C, Loquet I, Quarteronet D, Habert-Ortoli E. Cloning, pharmacological characterization, and anatomical distribution of a rat cDNA encoding for a galanin receptor. J Mol Neurosci 1995; 6: 33-41.
120. Howard A D, Tan C, Shiao L-L et al. Molecular cloning and chorocterization of a new receptor for galanin. FEBS Lett 1997; 405: 285-290.
121. Wang S, Hashemi T, He C, Strader C, Bayne M. Molecular cloning and pharmacological characterization of a new galanin receptor subtype. Mol Pharmacol 1997; 52: 337-343.
122. Smith K E, Forray C, Walker M W et al. Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover. J Biol Chem 1997; 272: 24612-24616.
123. Heuillet E, Bouaiche Z, Menager J et al. The human galanin receptor: ligand-binding and functional characteristics in the Bowes melanoma cell line. Eur J Pharmacol 1994; 139-147.
124. Fehmann H C, Habener J E Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma betaTC-1 cells. Endocrinology 1992; 130: 2890-2896.
125. Hammond P J, Smith D M, Akinsanya K O, Mufti W A, Wynick D, Bloom S R. Signalling pathways mediating secretory and mitogenic responses to galanin and pituitary adenylate cyclase activating polypeptide in the 235-1 clonal rat lactotroph cell line. J Neuroendocrinol 1996; 8: 457-464.
126. Ögren S-O, Hökfelt T, Kask K, Langel U, Bartfai T. The galanin antagonist M35 facilitates acquisition in the Morris swim maze. Neuroscience 1992; 51: 1-5.
127. Kahl U, Langel U, Bartfai T, Grundemar L. Functional effects and ligand binding of chimeric galanin-neuropeptide Y (NPY) peptides on NPY and galanin receptor subtypes. Br J Pharmacol 1994; 111: 1129-1134.