5' Heterogeneity in epithelial sodium channel α-subunit mRNA leads to distinct NH2-terminal variant proteins

American Journal of Physiology - Cell Physiology

Volumn 274, Issue 5 43-5, 1998, Pages

  Thomas, Christie P ^a,c   Auerbach, Scott ^a   Stokes, John B ^a,b   Volk, Kenneth A ^a  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

Alternate transcripts; Gene expression; Patch clamp; Sodium transport; Xenopus oocyte

Indexed keywords

AMINO ACID; COMPLEMENTARY RNA; MESSENGER RNA; PEPTIDE; PROTEIN; SODIUM; SODIUM CHANNEL;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; EPITHELIUM; EXON; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PATCH CLAMP; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SODIUM TRANSPORT; XENOPUS;

ANIMALIA;

EID: 0031803338     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1998.274.5.c1312     Document Type: Article

References (41)

1. Barbry, P., and M. Lazdunski. Structure and regulation of the amiloride-sensitive epithelial sodium channel. In: Ion Channels (1st ed.), edited by T. Narahashi. New York: Plenum, 1996, vol. 4, p. 115-167.
2. Boyd, D., and J. Beckwith. The role of charged amino acids in the localization of secreted and membrane proteins. Cell 62: 1031-1033, 1990.
3. Canessa, C. M., J. D. Horisberger, and B. C. Rossier. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 361: 467-470, 1993.
4. Canessa, C. M., A.-M. Merillat, and B. C. Rossier. Membrane topology of the epithelial sodium channel in intact cells. Am. J. Physiol. 267 (Cell Physiol. 36): C1682-C1690, 1994.
5. + channel is made of three homologous subunits. Nature 367: 463-467, 1994.
6. + channel by steroid hormones. EMBO J. 13: 2177-2181, 1994.
7. Chang, S. S., S. Grunder, A. Hanukoglu, A, Rosler, P. M. Mather, I. Hanukoglu, L. Schild, Y. Lu, R. A. Shimkets, C. Nelson-Williams, B. C. Rossier, and R. P. Lifton. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalemic acidosis, pseudohypoaldosteronism type 1. Nat. Genet. 12: 248-253, 1996.
8. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
9. Dagenais, A., R. Kothary, and Y. Berthiaume. The α subunit of the epithelial sodium channel in the mouse: developmental regulation of its expression. Pediatr. Res. 42: 327-334, 1997.
10. Denault, D. L., G. Fejes-Tóth, and A. Náray-Fejes-Tóth. Aldosterone regulation of sodium channel γ-subunit mRNA in cortical collecting duct cells. Am. J. Physiol. 271 (Cell Physiol. 40): C423-C428, 1996.
11. + channel subunit. Am. J. Physiol. 269 (Cell Physiol. 38): C641-C654, 1995.
12. Garty, H., and L. G. Palmer. Epithelial sodium channels: function and regulation. Physiol. Rev. 77: 359-396, 1997.
13. Hansson, J. H., C. Nelson-Williams, H. Suzuki, L. Schild, R. Shimkets, Y. Lu, C. M. Canessa, T. Iwasaki, B. R. Rossier, and R. P. Lifton. Human hypertension caused by mutation in the gamma subunit of the epithelial sodium channel: genetic heterogeneity of Liddle's syndrome. Nat. Genet. 11: 76-82, 1995.
14. Kozak, M. An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell Biol. 115: 887-903, 1991.
15. Kozak, M. Structural features in eukaryotic mRNAs that modulate the initiation of translation. J. Biol. Chem. 266: 19867-19870, 1991.
16. Kyte, J., and R. F. Doolittle. A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157: 105-132, 1982.
17. Li, M., Y. N. Jan, and L. Y. Jan. Specification of subunit assembly by the hydrophilic amino-terminal domain of the shaker potassium channel. Science 257: 1225-1230, 1992.
18. Li, X. J., R. H. Xu, W. B. Guggino, and S. H. Snyder. Alternatively spliced forms of the alpha subunit of the epithelial sodium channel: distinct sites for amiloride binding and channel pore. Mol. Pharmacol. 47: 1133-1140, 1995.
19. + channel are differently regulated by aldosterone. J. Biol. Chem. 269: 13736-13739, 1994.
20. + channel. FEBS Lett. 318: 95-99, 1993.
21. + channel determined by construction of multimeric cDNAs. Neuron 9: 861-871, 1992.
22. Mason, P. J., T. Enver, D. Wilkinson, and J. G. Williams. Assay of gene transcription in vivo. In: Gene Transcription (1st ed.), edited by B. D. Hames and S. J. Higgins. Oxford: IRL, 1993, p. 5-64.
23. McDonald, F. J., M. P. Price, P. M. Snyder, and M. J. Welsh. Cloning and expression of the β and γ subunits of the human epithelial sodium channel. Am. J. Physiol. 268 (Cell Physiol. 37): C1157-C1163, 1995.
24. + channel. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L728-L734, 1994.
25. + channels from the apical membrane of the rat cortical collecting tubule. Proc. Natl. Acad. Sci. USA 83: 2767-2770, 1986.
26. Prie, D., G. Friedlander, C. Coureau, A. Vandewalle, R. Cassingena, and P. M. Ronco. Role of adenosine on glucagon-induced cAMP in a human cortical collecting duct cell line. Kidney Int. 47: 1310-1318, 1995.
27. Pugh, B. F., and R. Tjian. Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell 61: 1187-1197, 1990.
28. + channel. J. Biol. Chem. 269: 12981-12986, 1994.
29. + channel in colon, lung and kidney. Pflügers Arch. 430: 299-307, 1995.
30. Rossier, B. C. The renal epithelial sodium channel: new insights into understanding hypertension. Adv. Nephrol. 25: 275-286, 1996.
31. Shimkets, R. A., D. G. Warnock, C. M. Bositis, C. Nelson-Williams, J. H. Hansson, M. Schambelan, J. R. Gill, S. Ulick, R. V. Milora, J. W. Findling, C. M. Canessa, B. C. Rossier, and R. P. Lifton. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79: 407-414, 1994.
32. Snyder, P. M., F. J. McDonald, J. B. Stokes, and M. J. Welsh. Membrane topology of the amiloride-sensitive epithelial sodium channel. J. Biol. Chem. 269: 24379-24383, 1994.
33. + channel. Cell 83: 969-978, 1995.
34. Strautnieks, S. S., R. J. Thompson, R. M. Gardiner, and E. Chung. A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three psuedohypoaldosteronism type 1 families. Nat. Gen. 13: 248-250, 1996.
35. + channel subunits are differentially regulated during development and by steroids. Am. J. Physiol. 269 (Cell Physiol. 38): C805-C812, 1995.
36. Thomas, C. P., N. A. Doggett, R. Fisher, and J. B. Stokes. Genomic organization and the 5′ flanking region of the gamma subunit of the human amiloride-sensitive epithelial sodium channel. J. Biol. Chem. 271: 26062-26066, 1996.
37. Verrall, S., and Z. W. Hall. The N-terminal domains of acetylcholine receptor subunits contain recognition signals for the initial steps of receptor assembly. Cell 68: 23-31, 1992.
38. + channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning. Proc. Natl. Acad. Sci. USA 91: 247-251, 1994.
39. + channel in the apical membrane of the rat renal inner medullary collecting duct. J. Clin. Invest. 96: 2748-2757, 1995.
40. Waldmann, R., G. Champigny, F. Bassilana, N. Voilley, and M. Lazdunski. Molecular cloning and functional expression of a novel amiloride-sensitive sodium channel. J. Biol. Chem. 270: 27411-27414, 1995.
41. Zeitlin, P. L., J. Lu, J. Rhim, G. Cutting, G. Stetten, K. A. Keiffer, R. Craig, and W. B. Guggino. A cystic fibrosis bronchial epithelial cell line: immortalization by adeno-12-SV40 infection. Am. J. Respir. Cell Mol. Biol. 4: 313-319, 1991.