Leucine turnover in patients with nephrotic syndrome: Evidence suggesting body protein conservation

Journal of the American Society of Nephrology

Volumn 9, Issue 6, 1998, Pages 1067-1073

  Lim, Victoria S ^a,e   Wolfson, Marsha ^b   Yarasheski, Kevin E ^c   Flanigan, Michael J ^a   Kopple, Joel D ^d  

^a UNIVERSITY OF IOWA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

^e UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOISOCAPROIC ACID; AMINO ACID; CARBON DIOXIDE; FOSINOPRIL; LEUCINE; NITROGEN; PROTEIN;

ADULT; AGED; ARTICLE; CALORIC INTAKE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DOWN REGULATION; FEMALE; GAS CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; NEPHROTIC SYNDROME; NITROGEN BALANCE; NITROGEN METABOLISM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTAKE; PROTEIN METABOLISM; PROTEINURIA; TURNOVER TIME;

EID: 0031801192     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Oliver J, MacDowell M: Cellular mechanisms of protein metabolism in the nephron. J Exp Med 107: 731-754, 1958
2. Spector WG: The reabsorption of labeled proteins by the normal and nephrotic rat kidney. J Pathol 68: 187-196, 1954
3. Jensen H, Rossing N, Andersen SB, Jarnum S: Albumin metabolism in the nephrotic syndrome in adults. Clin Sci 33: 445-457, 1967
4. Kaysen GA, Kirkpatrick WG, Couser WG: Albumin homeostasis in the nephrotic rat: Nutritional considerations. Am J Physiol 247: F192-F202, 1984
5. Kaysen GA, Gambertoglio J, Jimenez I, Jones H, Hutchison FN: Effect of dietary protein intake on albumin homeostasis in nephrotic patients. Kidney Int 29: 572-577, 1986
6. 1983 metropolitan height and weight tables. Stat Bull Metrop Insur Co 64: 3-9, 1983
7. Blumenkratz MJ, Kopple JD, Moran JK, Coburn JW: Metabolic balance studies and dietary protein requirements in patients undergoing continuous ambulatory peritoneal dialysis. Kidney Int 21: 849-861, 1982
8. Kopple JD, Bernard D, Messana J, Swartz R, Bergstrom J, Lindhom B, Lim V, Brunori G, Leiserowitz M, Bier DM, Stegink LD, Martis L, Algrim Boyle C, Serkes KD, Vonesh E, Jones MR: Treatment of malnourished CAPD patients with an amino acid based dialysate. Kidney Int 47: 1148-1157, 1995
9. Borah MF, Schoenfeld PY, Gotch FA, Sargent JA, Wolfson M, Humphries MH: Nitrogen balance during intermittent dialysis therapy of uremia. Kidney Int 14: 491-500, 1978
10. Lim VS, Flanigan MJ, Zavala DC, Freeman RM: Protective adaptation of low serum triiodothyronine in patients with chronic renal failure. Kidney Int 28: 541-549, 1985
11. Motil KJ, Matthews DE, Bier DM, Burke JF, Munro HN, Young VR: Whole-body leucine and lysine metabolism: Response to dietary protein intake in young men. Am J Physiol 240: E712-E721, 1981
12. Matthews DE, Ben-Galim E, Bier DM: Determination of stable isotopic enrichment in individual plasma amino acids by chemical ionization mass spectrometry. Anal Chem 51: 80-84, 1979
13. 13C] leucine infusion in man: A method for measuring human intracellular leucine tracer enrichment. Metabolism 31: 1105-1112, 1982
14. Schwenk WF, Beaufrere B, Haymond MW: Use of reciprocal pool specific activities to model leucine metabolism in humans. Am J Phvsiol 249: E646-E650, 1985
15. 3 infused by gut and vein: Effect of feeding. Am J Physiol 257: E426-E438, 1989
16. Bier DM, Matthews DE, Young VR: Interpretation of amino acid kinetic studies in the context of whole-body protein metabolism. In: Substrate and Energy Metabolism, edited by Garrow JS, Halliday D, John Libbey, 1985, pp 27-36
17. Bier DM: Intrinsically difficult problems: The kinetics of body proteins and amino acids in man. Diabetes Metab Rev 5: 111-132, 1989
18. Lim VS, Bier DM, Flanigan MJ, Sum-Ping ST: The effect of hemodialysis on protein metabolism. J Clin Invest 91: 2429-2436, 1993
19. Munro HN, Flick A: Analysis of tissue and body fluids for nitrogenous constituents. In: Mamalian Protein Metabolism, edited by Munro HN, Vol. 3., New York, Academic Press, 1969, p 508
20. Mitch WE, May RC, Maroni BJ: Mechanisms for abnormal protein metabolism in uremia. J Am Coll Nutr 8: 305-309, 1989
21. Maroni BJ, Staffeld C, Young VR, Manatunga A, Tom K: Mechanisms permitting nephrotic patients to achieve nitrogen equilibrium with a protein-restricted diet. J Clin Invest 99: 2479-2487, 1997
22. Campbell WW, Crim MC, Young VR, Joseph LJ, Evans WJ: Effects of resistance training and dietary protein intake on protein metabolism in older adults. Am J Physiol 268: E1143-E1153, 1995
23. Goodship THJ, Mitch WE, Hoerr RA, Wagner DA, Steinman TI, Young VR: Adaptation to low-protein diets in renal failure: Leucine turnover and nitrogen balance. J Am Soc Nephrol 1: 66-75, 1990
24. Goodship THJ, Lloyd S, Clague MB, Bartlett K, Ward MK, Wildinson R: Whole body leucine turnover and nutritional status in continuous ambulatory peritoneal dialysis. Clin Sci 73: 463-469, 1987
25. Subcommittee on the Tenth Edition of the RDAs. Food and Nutrition Board, Commission on Life Sciences, National Research Council: Recommended Dietary Allowances, 10th Edition, Washington, National Academy Press, 1989