Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae

Genetics

Volumn 149, Issue 2, 1998, Pages 879-892

  Grishin, Anatoly V ^a,b   Rothenberg, Michael ^a,c   Downs, Maureen A ^a   Blumer, Kendall J ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PHEROMONE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MOT 3; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; GENE REPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; RECESSIVE GENE; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; BINDING SITES; CLONING, MOLECULAR; CONSENSUS SEQUENCE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; MOLECULAR SEQUENCE DATA; PEPTIDES; PHEROMONES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 0031800748     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. BARDWELL, L., J. G. COOK, C. J. INOUYE, and J. THORNER, 1994 Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae. Dev. Biol. 166: 363-379.
2. CADE, R. M., and B. ERREDE, 1994 MOT2 encodes a negative regulator of gene expression that affects basal expression of pheromone-responsive genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 14: 3139-3149.
3. CHEN, Q., and J. B. KONOPKA, 1996 Regulation of the G-protein-couple alpha-factor pheromone receptor by phosphorylation. Mol. Cell. Biol. 16: 247-257.
4. CHOO, Y., and A. KLUG, 1997 Physical basis of a protein-DNA recognition code. Curr. Op. Struct. Biol. 7: 117-125.
5. CIEJEK, E., and J. THORNER, 1979 Recovery of S. cerevisiae a cells from G1 arrest by alpha factor phermone requires endopeptidase action. Cell 18: 623-635.
6. COLLART, M. A., 1996 The NOT, SPT3, and MOT1 genes functionally interact to regulate transcription at core promoters. Mol. Cell. Biol. 16: 6668-6676.
7. DAVIS, T. L., R. KUNISAWA and J. THORNER, 1992 A presumptive helicase (MOT1 gene product) affects gene expression and is require for ivability in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol 12: 1879-1892.
8. DE BARROS LOPES, M., J. Y. HO and S. I. REED, 1990 Mutations in cell division cycle genes CDC36 and CDC39 activate the Saccharomyces cerevisiae mating pheromone response pathway. Mol. Cell. Biol. 10: 2966-2972.
9. DOHLMAN, H. G., J. SONG, D. MA, W. E. COURCHESNE and J. THORNER, 1996 Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, genetic interaction and physical association with Gpa1 (G protein alpha subunit). Mol. Cell. Biol. 16: 5194-5209.
10. DOI, K., A. GARTNER, G. AMMERER, B. ERREDE, H. SHINKAWA et al., 1994 MSG5, a novel protein phosphatase promotes adaption to pheromone response in S. cerevisiae. EMBO J. 13: 61-70.
11. EVANS, R. M., and S. M. HOLLENBERG, 1988 Zinc fingers: gilt by association. Cell 52: 1-3.
12. FIELDS, S., and I. HERSKOWITZ, 1987 Regulation by the yeast mating-type locus of STE12, a gene required for cell-type-specific expression Mol. Cell. Biol. 7: 3818-3821.
13. FLICK, J. S., and M. JOHNSTON, 1990 Two systems of glucose repression of the GAL1 promoter in Saccharomyces cerevisae. Mol. Cell. Biol 10: 4757-4569.
14. GREISMAN, H. A., and C. O. PABO, 1997 A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science 275: 657-661.
15. GRISHIN, A. V., J. L. WEINER and K. J. BLUMER, 1994 Control of adaptation to mating pheromone by G protein beta subunites of Sacchraomyces cerevisiae. Genetics 138: 1081-1092
16. GUARENTE, L., and E. HOAR, 1984 Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the "TATA box." Proc. Natl. Acad. Sci. USA 81: 7860-7864.
17. GUTHRIE, C., and G. R. FINK, 1991 Guide to Yeast Genetics and Molecular Biology. Meth. Enzymol. 194: 1-933.
18. HILL, J. E., A. M. MYERS, T. J. KOERNER and A. TZAGOLOFF, 1986 Yeast/E. coli shuttle vectors with multiple unique restriction sites. Yeast 2: 163-167.
19. IRIE, K., K. YAMAGUCHI, K. KAWASE and K. MATSUMOTO, 1994 The yeast MOT2 gene encodes a putative zinc finger protein that serves as a global negative regulator affecting expression of several categories of genes, including mating-pheromone-responsive genes. Mol. Cell. Biol. 14: 3150-3157.
20. JACKSON, C. L., J. B. KONOPKA and L. H. HARTWELL, 1991 S. cerevisiae alpha pheromone receptors activate a novel signal transduction pathway for mating partner discrimination. Cell 67: 389-402.
21. JENNESS, D. D., and P. SPATRICK, 1986 Down regulation of the alpha-factor pheromone recpetor in S. cerevisiae. Cell 46: 345-353.
22. KELEHER, C. A., M. J. REDD, J. SCHULTZ, M. CARLSON and A. D. JOHNSON, 1992 Ssn6-Tup1 is a general repressor of transcription in yeast. Cell 68: 709-719.
23. KLUG, A., and D. RHODES, 1987 Zinc fingers: a novel protein fold for nucleic acid recognition. Cold Spring Harbor Symp. Quant. Biol. 52: 473-482.
24. LEBERER, E., D. DIGNARD, D. HARCUS, M. WHITEWAY and D. Y. THOMAS, 1994 Molecular characterization of SIG1, a Saccharomyces cerevisiae gene involved in negative regulation of G-protein-mediated signal transduction. EMBO J. 13: 3050-3064.
25. MA, J., and M. PTASHNE, 1987 A new class of yeast transcriptional activators. Cell 51: 113-119.
26. MACKAY, V. L., S. K. WELCH, M. Y. INSLEY, T. R. MANNEY, J. HOLLY et al., 1988 The Sacchraomyces cerevisiae BAR1 gene encodes an exported protein with homology to pepsin. Proc. Natl. Acad. Sci. USA 85: 55-59.
27. MADISON, J. M., and F. WINSTON, 1997 Evidence that Spt3 functionally interacts with Mot1, TFIIA, and TATA-binding protein to confer promoter-specific transcriptional control in Saccharomyces cerevisiae. Mol. Cell. Biol. 17: 287-295.
28. MADISON, J. M., A. DUDLEY, C. HONGAY and F. WINSTON, 1998 Identification and analysis of Mot3, a zinc finger protein that binds retrotransposon Ty LTR (δ) in Saccharomyces cerevisiae. Mol. Cell. Biol. 18: 1879-1890.
29. MCCAFFREY, G., F. J. CLAY, K. KELSAY and G. J. SPRAGUE, 1987 Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 7: 2680-2690.
30. MELUH, P. B., and M. D. ROSE, 1990 KAR3, a kinesin-related gene required for yeast nuclear fusion. Cell 60: 1029-1041.
31. MERCADO, J. J., and J. M. GANCEDO, 1992 Regulatory regions in the yeast FBP1 and PCK1 genes. FEBS Lett. 311: 110-114.
32. MYERS, A. M., A. TZAGOLOFF, D. M. KINNEY and C. J. LUSTY, 1986 Yeast shuttle and integrate vectors with multiple cloning sites suitable for construction of lacZ fusions. Gene 45: 299-10.
33. NEIMAN, A. M., F. CHANG, K. KOMACH, and I. HERSKOWITZ, 1990 CDC36 and CDC39 are negative elements in the signal transduction pathway of yeast. Cell Reg. 1: 391-401
34. NIEDENTHAL, R. K., L. RILES, M. JOHNSTON and J. H. HEGEMANN, 1996 Green fluorescent protein as a marker for gene expression and subcellular localization in budding yeast. Yeast 12: 773-786.
35. OEHLEN, L. J. W. M., and F. R. CROSS, 1994 G1 cyclins Cln1 and Cln2 repress the mating factor response pathway at Start in the yeast cell cycle. Genes Dev. 8: 1058-1070.
36. OZCAN, S., and M. JOHNSTON, 1996a Two different repressors collaborate to restrict expression of the yeast glucose transporter genes HXT2 and HXT4 to low levels of glucose. Mol. Cell. Biol. 16: 5536-5545.
37. OZCAN, S., and M. JOHNSTON, 1996b Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription. Mol. Cell. Biol. 16: 6419-6424.
38. RENEKE, J. E., K. J. BLUMER, W. E. COURCHESNE and J. THORNER, 1988 The carboxy-terminal segment of the yeast alpha-factor receptor is a regulatory domain. Cell 55: 221-234.
39. RHODES, N., L. CONNELL and B. ERREDE, 1990 STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast. Genes Dev. 4: 1862-1874.
40. ROSE, M. D., P. NOVICK, J. H. THOMAS, D. BOTSTEIN and G. R. FINK, 1987 A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene 60: 237-243.
41. ROTHSTEIN, R., 1991 Targeting, disruption, replacement, and allele rescue: integrative DNA transformation in yeast. Meth. Enzymol. 194: 281-301.
42. SEGALL, J. E., 1993 Polarization of yeast cells in spatial gradients of alpha mating factor. Proc. Natl. Acad. Sci. USA 90: 8332-8336.
43. SHERMAN, F., 1991 Getting started with yeast. Meth. Enzymol. 194: 3-21.
44. SIKORSKI, R. S., and P. HIETER, 1989 A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19-27.
45. SINGER, V. L., C. R. WOBBE and K. STRUHL, 1990 A wide variety of DNA sequences can functionally replace a yeast TATA element for transcriptional activation. Genes Dev. 4: 636-645.
46. TEAGUE, M. A., D. T. CHALEFF and B. ERREDE, 1986 Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases. Proc. Natl. Acad. Sci. USA 83: 7371-7375.
47. TJIAN, R., and T. MANIATIS, 1994 Transcriptional activation: a complex puzzle with few easy pieces. Cell 77: 5-8
48. VAN SOLINGEN, P., and J. B. VAN DER PLATT, 1977 Fusion of yeast spheroplasts. J. Bacteriol. 130: 946-947.
49. WATSON, N., M. E. LINDER, K. M. DRUEY, J. H. KEHRL and K. J. BLUMER, 1996 RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunites. Nature 383: 172-175.
50. WEINER, J. L., C. GUTTIEREZ-STEIL and K. J. BLUMER, 1993 Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway. J. Biol. Chem. 268: 8070-8077.
51. WHITEWAY, M., L. HOUGAN, D. DIGNARD, D. Y. THOMAS, L. BELL et al., 1989 The STE4 and STE18 genes of yeast encode potential beta and gamma subunits of the mating factor receptor-coupled G protein. Cell 56: 467-477.
52. ZHAN, X. L., R. J. DESCHENES and K. L. GUAN, 1997 Differential regulation of Fus3 MAP kinase by tyrosine-specific phosphatases Ptp2/Ptp3 and dual-specificity phosphatase Msg5 in Saccharomyces cerevisiae. Genes Dev. 11: 1690-1702.