Effects of interferon-α therapy on immune parameters in immune thrombocytopenic purpura

Autoimmunity

Volumn 24, Issue 2, 1996, Pages 81-100

  Crossley, A R ^a   Dickinson, A M ^a   Proctor, S J ^a   Calvert, J E ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Cytokine; Immune (idiopathic) thrombocytopenic purpura; Interferon alpha; Th subsets

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MALE; MONONUCLEAR CELL; NATURAL KILLER CELL; T LYMPHOCYTE; THROMBOCYTE COUNT;

EID: 0029800873     PISSN: 08916934     EISSN: None     Source Type: Journal    
DOI: 10.3109/08916939609001950     Document Type: Article

References (45)

1. McMillan, R. Chronic idiopathic thrombocytopenic pupura. N. Engl. J. Med 1981; 304: 1135-1147.
2. Van Leeuwen, E. F., Van der Ven, J. T. H., Engelfriet, C. P., von dem Borne, A. E. G. K. Specificity of autoantibodies in autoimmune thrombocytopenia. Blood 1982; 59: 23-26.
3. Szatowski, N. S., Kunicki, T. J., Aster, R. H. Identification of glycoprotein Ib as a target for autoantibody in idiopathic (autoimmune) thrombocytopenic purpura. Blood 1986; 67: 2321-2326.
4. He, R., Reid, D. M., Jones, C. E., Shulman, N. R. Spectrum of Ig classes, specificities, and titers of serum antiglycoproteins in chronic idiopathic thrombocytopenic purpura. Blood 1994; 83: 1024-1032.
5. Mylvaganum, R., Ahn, Y. S., Harrington, W. J., Kim, C. I., Gratzner, H. G. Differences in T cell subsets between men and women with idiopathic thrombocytopenic purpura. Blood 1985; 66: 967-972.
6. Peller, S., Kaufman, S., Shaked, U. Immunoregulatory defect in patients with autoimmune thrombocytopenic purpura (ATP). Thymus 1986; 8: 361-367.
7. Garcia-Suarez, J., Prieto, A., Reyes, E., Manzano, L., Merino, J. L., Alvarez-Mon, M. The clinical outcome of autoimmune thrombocytopenic purpura patients is related to their T cell immunodeficiency. Brit. J. Haematol. 1993; 84: 464-470.
8. Berchtold, P., McMillan, R. Therapy of chronic idiopathic thrombocytopenic purpura adults. Blood 1989; 74: 2309-2317.
9. Proctor, S. J., Jackson, G., Carey, P., Stark, A. Short-course alpha-interferon therapy in severe unresponsive immune thrombocytopenic purpura. Lancet 1988; i: 947.
10. Proctor, S. J. Alpha interferon therapy in the treatment of idiopathic thrombocytopenic purpura. Eur. J. Cancer 1991; 27(Suppl. 4): S63-S68.
11. Vianelli, N., Catani, L., Gugliotta, L., Belmonte, M. M., Cascione, L., Colangeli, V., et al. Recombinant alpha-interferon 2b in the treatment of HIV-related thrombocytopenia. AIDS 1993; 7: 823-827.
12. Ellis, M. E., Neal, K. R., Leen, C. L. S., Newland, A. C. Alfa-2a recombinant interferon in HIV associated thrombocytopenia. Br. Med. J. 1987; 295: 1519.
13. Lever, A. M., Brook, M. G., Yap, I., Thomas, H. C. Treatment of thrombocytopenia with alfa interferon. Brit. Med. J. 1987; 295: 1519-1520.
14. Behrenbeck, U., Riedel, F., Rieger, C. H. L. Increase in platelet count following short course therapy with recombinant alpha-2b-interferon in immune thrombocytopenic purpura in childhood. Pediatr. Allergy Immunol. 1993; 4: 10-12.
15. Velu, T., Delwiche, F., Gangii, D., Monsier, R., Flament, J., Stryckmans, B. et al. Therapeutic effect of human recombinant interferon-alpha-2c in essential thrombocythaemia. Oncology 1985; 42 (suppl. I): 10-14.
16. Giles, F. J., Singer, C. R. J., Gray, A. G., Yong, K. L., Brozovic, M., Davies, S. C. et al. Alpha-interferon therapy for essential thrombocythaemia. Lancet 1988; ii: 70-72.
17. Bellucci, S., Harousseau, J. L., Brie, P., Tobelem, G. Treatment of essential thrombocythaemia by alpha 2a interferon. Lancet 1988; ii: 960-961.
18. Gisslinger, H., Ludwig, H., Linkesch, W., Chott, A., Fritz, E., Radaszkiewicz, T. Long-term interferon therapy for thrombocytosis in myeloproliferative diseases. Lancet 1989; i: 634-637.
19. Talpaz, M., Kurzock, R., Kantarjian, H., O'Brien, S., Gutterman, J. U. Recombinant interferon-alpha therapy of Philadelphia chromosome-negative myeloproliferative disorders with thrombocytosis. Am. J. Med. 1989; 86: 554-558.
20. Gutterman, J. U. Cytokine therapeutics: lessons from interferon alpha. [Review]. Proc. Natl. Acad. Sci. U.S.A. 1994; 91: 1198-205.
21. Neubauer, R. H., Goldstein, L., Rabin, H., Stebbing, N. Stimulation of in vitro immunoglobulin production by interferon-alpha. J. Immunol. 1985; 134: 299-304.
22. Fleisher, T. A., Attallah, A. M., Tosato, G., Blaese, M., Greene, W. C. Interferon-mediated inhibition of human polyclonal immunoglobulin synthesis. J. Immunol. 1982; 129: 1099-1103.
23. Pelton, B. K., Denman, A. M. Immunoregulatory effects of interferon-alpha. I. Interferon-alpha inhibits in vitro antibody synthesis by normal human lymphocytes. Clin. exp. Immunol. 1985; 59: 398-404.
24. Peters, M., Ambrus, J. L., Zheleznyak, A., Walling, D., Hoofnagle, J. H. Effect of interferon-alpha on immunoglobulin synthesis by human B cells. J. Immunol. 1986; 137: 3153-3157.
25. Pene, J., Rousset, F., Briere, F., Chretien, I., Bonnefoy, J. Y., Spits, H., et al. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc. Natl. Acad. Sci. U.S.A. 1988; 85: 6880-6884.
26. Welsh, R. M. Natural killer cells and interferon. [Review]. Critical Reviews in Immunology 1984; 5: 55-93.
27. Parronchi, P., De Carli, M., Manetti, R., Simonelli, C., Sampognaro, S., Piccini, M-P. et al. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. J. Immunol. 1992; 149: 2977-2983.
28. Romagnani, S. Induction of Th1 and Th2 responses: a key role for the 'natural' immune response? Immunology Today 1992; 13: 379-381.
29. Kiefel, V., Santoso, S., Weisheit, M., Mueller-Eckhardt, C. Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies. Blood 1987; 70: 1722-1726.
30. Dickinson, A. M., Proctor, S. J., Jacobs, E., Reid, A. M., Walker, W., Craft, A. W. et al. Natural killer cell activity in childhood acute lymphoblastic leukaemia in remission. British Journal of Haematology 1985; 59: 45-53.
31. Hazlewood, M., Kumararatne, D. S. The spleen? Who needs it anyway? Clin. exp. Immunol. 1992; 89: 327-329.
32. Romagnani, S. Lymphokine production by human T cells in disease states. Annn. Rev. Immunol. 1994; 12: 227-257.
33. Goldman, M., Druet, P., Gleichmann, E. TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunology Today 1991; 12: 223-227.
34. Semple, J. W., Freedman, J. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. Blood 1991; 78: 2619-2625.
35. Del Prete, G. F., de Carli, M., Ricci, M., Romagnani, S. Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. J. Exp. Med. 1991; 174: 809-813.
36. Gruschwitz, M. S., Peters, K. P., Heese, A., Stosiek, N., Koch, H. U., Hornstein, O. P. Effects of interferon-alpha-2b on the clinical course, inflammatory skin infiltrates and peripheral blood lymphocytes in patients with severe atopic eczema. Int. Arch. Allergy. Appl. Immunol. 1993; 101: 20-30.
37. Souillet, G., Rousset, F., De Vries, J. E. Alpha-interferon treatment of patient with hyper IgE syndrome. Lancet 1989; i: 1384.
38. Ferrick, D. A., Schrenzel, M. D., Mulvania, T., Hsieh, B., Ferlin, W. G., Lepper, H. Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma/delta T cells in vivo. Nature 1995; 373: 255-257.
39. Lagoo, A. S., Eldridge, J. H., Lagoo-Deenadaylan, S., Black, C. A., Ridwan, B. U., Hardy, K. J. et al. Peyer's patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion. Eur. J. Immunol. 1994; 24: 3087-3092.
40. Bordin, J. O., Smith, J. W., Hayward, C. P. M. W. T. E., Wasi, P., Kelton, J. G. Bacterial infection-associated improvement of platelet counts in two patients with chronic and unresponsive idiopathic thrombocytopenic purpura with normal platelet survival studies. Brit. J. Haematol. 1995; 90: 332-335.
41. Ballem, P. J., Segal, G. M., Stratton, J. R., Gernsheimer, T., Adamson, J. W., Slichter, S. J. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. J. Clin. Invest. 1987; 80: 33-40.
42. Pancre, V., Joseph, M., Capron, A., Wietzerbin, J., Kurnierz, J-P., Vorng, H. et al. Recombinant human interferon-gamma induces increased IgE receptor expression on human platelets. Eur. J. Immunol. 1988; 18: 829-832.
43. Fujisawa, K., Tani, P., Piro, L., McMillan, R. The effect of therapy on platelet-associated autoantibody in chronic immune thrombocytopenic purpura. Blood 1993; 81: 2872-2877.
44. Semple, J. W., Bruce, S., Freedman, J. Suppressed natural killer cell activity in patients with chronic autoimmune thrombocytopenic purpura. Am. J. Haematol. 1991; 37: 258-262.
45. Semple, J. W., Freedman, J. Natural killer cell numbers and activity in patients with chronic autoimmune thrombocytopenic purpura [letter; comment]. Blood 1994; 83: 870-871.