Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors

Journal of Medicinal Chemistry

Volumn 41, Issue 11, 1998, Pages 1956-1961

  Guan, Jian ^a   Zhu, Xiao Kang ^a   Tachibana, Yoko ^a   Bastow, Kenneth F ^a   Brossi, Arnold ^a   Hamel, Ernest ^b   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3 O ACETYL 1,2,3 DEMETHYL N (NITROBENZOYL)DEACETYLTHIOCOLCHICINE; ANTINEOPLASTIC AGENT; COLCHICINE DERIVATIVE; GYRASE INHIBITOR; TRIDEMETHYLTHIOCOLCHICINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL DEATH; CYTOTOXICITY; DEMETHYLATION; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHILICITY; TUMOR CELL LINE;

EID: 0032554863     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980007f     Document Type: Article

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