Area and depth of surfactant-induced corneal injury predicts extent of subsequent ocular responses

Investigative Ophthalmology and Visual Science

Volumn 39, Issue 13, 1998, Pages 2610-2625

  Jester, James V ^a   Petroll, W Matthew ^a   Bean, Jacquelyn ^a   Parker, Ron D ^b   Carr, Gregory J ^b   Cavanagh, H Dwight ^a   Maurer, James K ^b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SURFACTANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA INJURY; CORNEA STROMA; CORNEA THICKNESS; EYE IRRITATION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALS; CELL COUNT; CELL SIZE; CORNEA; CORNEAL DISEASES; CORNEAL STROMA; EPITHELIUM, CORNEAL; MICROSCOPY, CONFOCAL; RABBITS; SURFACE-ACTIVE AGENTS;

EID: 0031793265     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Jester JV, Maurer JK, Petroll WM, Wilkie DA, Parker RD, Cavanagh HD. Application of in vivo confocal microscopy to the understanding of surfactant-induced ocular irritation. Toxicol Pathol. 1996; 24:412-428.
2. Maurer JK, Li H-F, Petroll WM, Parker RD, Cavanagh HD, Jester JV. Confocal microscopic characterization of initial changes of surfactant-induced eye irritation occurring in the rabbit. Toxicol Appl Pharmacol. 1997;143:291-300.
3. Maurer JK, Parker RD. Light microscopic comparison of surfactant-induced eye irritation in rabbits and rats at 3 hours and recovery/ day 35. Toxicol Pathol. 1996;24:403-411.
4. Maurer JK, Parker RD, Carr GJ. Ocular irritation: microscopic changes occurring over time in the rat with surfactants of known irritancy. Toxicol Pathol. 1998;26:217-225.
5. Jester JV, Li H-F, Petroll WM, Parker RD, Cavanagh HD, Carr GJ, Smith B, Maurer JK. Area and depth of surfactant induced corneal injury correlates with cell death. Invest Ophthalmol Vis Sci. 1998; 39:922-936.
6. Li H-F, Petroll WM, Maurer JK, Cavanagh HD, Jester JV. Epithelial and corneal thickness measurements by in vivo confocal microscope through focus. Curr Eye Res. 1997;16:214-221.
7. Moller-Pedersen T, Vogel M, Li H-F, Petroll WM, Cavanagh HD, Jester JV. Quantification of stromal thinning, epithelial thickness, and corneal haze following photorefractive keratectomy using in vivo confocal microscopy. Ophthalmology. 1997;104:360-368.
8. Moller-Pedersen T, Li H-F, Petroll WM, Cavanagh HD, Jester JV. Confocal microscopic characterization of wound repair following photorefractive keratectomy. Invest Ophthalmol Vis Sci. 1998;39: 487-501.
9. Draize JHG, Woodard G, Calvery HO. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther. 1944;82:377-390.
10. Snedecor GW, Cochran WG. Statistical Methods. 8th ed. Iowa State Ames, IA: University Press; 1989:142-236.
11. Bailer AJ. Testing for the equality of area under the curves when using destructive measurement techniques. J Pharmacokinet Biopharm. 1988;16:303-309.
12. Ichijima H, Petroll WM, Andrews PM, Barry PA, Dai M, Jester JV, Cavanagh HD. In vivo confocal microscopic studies of endothelial wound healing in rabbit cornea. Cornea. 1993;12:369-378.
13. Chew SJ, Beuerman RW, Kaufman HE, McDonald MB. In vivo confocal microscopy of corneal wound healing after excimer laser photorefractive keratectomy. CLAO J. 1995;21:273-280.
14. Talsma DM, Leach CL, Hatoum NS, Gibbons RD, Roger J-C, Garvin PJ. Reducing the number of rabbit in the Draize eye irritancy test. A statistical analysis of 155 studies conducted over 6 years. Fundam Appl Toxicol. 1988;10:146-153.
15. Williams SJ, Graepel GJ, Kennedy GL. Evaluation of ocular irritancy potential: intralaboratory variability and effect of dosage volume. Toxicol Lett. 1982;12:235-241.
16. Williams SJ. Changing concepts of ocular irritation evaluation: pitfalls and progress. Fundam Chem Toxicol. 1985;23:189-193.
17. Weltman AS, Sparber SB, Jurtshuk T. Comparative evaluation and influence of various factors on eye irritation scores. Toxicol Appl Pharmacol. 1965;7:308-319.