Cimetidine reduces weight and improves metabolic control in overweight patients with Type 2 diabetes

International Journal of Obesity

Volumn 22, Issue 11, 1998, Pages 1041-1045

  Stoa Birketvedt G ^a,d   Paus, P N ^c   Ganss, R ^c   Ingebretsen, O C ^b   Florholmen, J ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^c AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

H2 receptor antagonist; Hyperlipidemia; Insulin resistance; Obesity; Weight reduction

Indexed keywords

CIMETIDINE; GLUCOSE; INSULIN; LIPID; TRIACYLGLYCEROL;

ADULT; ANTHROPOMETRIC PARAMETERS; APPETITE; ARTICLE; BLOOD PRESSURE; BODY FAT; BODY MASS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

EID: 0031791354     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800721     Document Type: Article

References (23)

1. Knowler WC, Pettitt DJ, Savage PJ, Bennett PH. Diabetes incidence in Pima Indians: contributions of obesity and parental diabetes. Am J Epidemiol 1981; 113: 144-156.
2. Ohlson LO, Larsson B, Svärdsudd K, Welin L, Eriksson H, Wilhelmsen L, Bjömtorp P, Tibblin G. The influence of body fat distribution on the incidence of diabetes mellitus: 13.5 years of follow-up of the participants in the study of men born in 1913. Diabetes 1985; 34: 1055-1058.
3. Després J-P, Marette A. Relation of components of insulin resistance syndrome to coronary disease risk. Curr Opin Lipidol 1994; 5: 274-289.
4. Björntorp P. Abdominal obesity and the development of noninsulin dependent diabetes mellitus. Diabet Met Rev 1988; 4: 615-622.
5. Park KS, Rhee BD, Lee K-U, Kim SY, Lee HK, Koh C-S, Min HK. Intra-abdominal fat is associated with decreased insulin sensitivity in healthy young men. Metabolism 1991; 40: 600-603.
6. Perriello G, Misericordia P, Volpi E, Pampanelli S, Santeusanio F, Brunetti P, Bolli GB. Contribution of obesity to insulin resistance in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1995; 80: 2464-2469.
7. Ludvik B, Nolan JJ, Baloga J, Sacks D, Olefsky J. Effect of obesity on insulin resistance in normal subjects and patients with NIDDM. Diabetes 1995; 44: 1121-1125.
8. Goldstein DJ. Beneficial health effects of modest weight loss. Int J Obes 1992; 16: 397-415.
9. Tremblay A, Després J-P, Maheux J, Pouliot MC, Nadeau A, Moorjani S, Lupien PJ, Bouchard C. Normalization of the metabolic profile in obese women by exercise and a low fat diet. Med Sci Sport Exercise 1991; 23: 1326-1331.
10. Henry RR, Gumbiner B. Benefits and limitations of very-low-calorie diet therapy in obese NIDDM. Diabetes Care 1991; 14: 802-823.
11. Després J-P, Lemieux S, Lamarche B, Prud'homme D, Moorjani S, Brun L-D, Gagné C, Lupien PJ. The insulin resistance-dyslipidemic syndrome: contribution of visceral obesity and therapeutic implications. Int J Obes 1995; 19 (Suppl 1): S76-S86.
12. Støa-Birketvedt G. Effect of cimetidine suspension on appetite and weight in overweight subjects. BMJ 1993; 306: 1091-1093.
13. Støa-Birketvedt G, Løvhaug N, Vonen B, Florholmen J. A H-2-receptor antagonist reduces food intake and weight gain in rats via non-gastric secretory mechanisms. Acta Phys Scand 1997; 161: 489-494.
14. Støa-Birketvedt G, Vonen B, Waldum HL, Florholmen J. The effect of cimetidine on plasma levels of cholecystokinin and gastrin in healthy volunteers. Acta Phys Scand 1997; 159: 321-325.
15. Støa-Birketvedt G, Thom E, Aarbakke J, Florholmen J. Body fat as a predictor of the antihypertensive effect of nifedipine. J Int Med 1995; 237: 169-173.
16. Vonen B, Florholmen J, Malm D, Torjessen P, Burhol PG. Glucagon mediates arginine-induced somatostatin secretion from isolated rat pancreatic islets. Scand J Clin Lab Invest 1992; 52: 107-112.
17. Burstein M, Scholnick HR, Morfin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 1970; 11: 583-595.
18. Gibbs J, Young RC, Smith GP. Cholecystokinin decreases food intake in rats. J Comp Physiol Psychol 1973; 84: 488-493.
19. Council of scientific affairs. Treatment of obesity in adults. JAMA 1988; 260: 2547-2551.
20. Muls E, Kempen K, Vansant G, Saris W. Is weight cycling detrimental to health? A review of the literature in humans. Int J Obes 1995; 19 (Suppl 3): S46-S50.
21. Stanik S, Marcus R. Insulin secretion improves following dietary control of plasma glucose in severely hyperglycemic obese patients. Metabolism 1980; 29: 346-350.
22. Després J-P, Prud'homme D, Pouliot M-C, Tremblay A, Bouchard C. Estimation of deep abdominal adipose-tissue accumulation from simple anthropometric measurements in men. Am J Clin Nutr 1991; 54: 471-477.
23. Campbell PJ, Gerich JE. Impact of obesity on insulin action in volunteers with normal glucose tolerance: demonstration of a threshold for the adverse effect of obesity. J Clin Endocrinol Metah 1990; 70: 1114-1118.