The psychopharmacology of isatin: A brief review

Stress Medicine

Volumn 14, Issue 4, 1998, Pages 225-229

  Glover, Vivette ^a   Attach, S K B H ^a   Rya, A ^a  

^a QUEEN CHARLOTTE S AND CHELSEA HOSPITAL   (United Kingdom)

Author keywords

ANP; HPA axis; Isatin; Monoamines; Stress

Indexed keywords

ATRIAL NATRIURETIC FACTOR RECEPTOR; CYCLIC GMP; DOPAMINE; HYDROCORTISONE; INDOLE; ISATIN; MONOAMINE OXIDASE B INHIBITOR; PENTETRAZOLE; SEROTONIN; TRIBULIN;

AMNESIA; ANTIDIURESIS; BODY DISTRIBUTION; BRAIN; BRAIN LEVEL; BULIMIA; CEREBELLUM; CEREBROSPINAL FLUID; CONFERENCE PAPER; FOOD INTAKE; HIPPOCAMPUS; HUMAN; MOUSE; PRIMATE; RAT; RECEPTOR BLOCKING; SECOND MESSENGER; SEDATION; STRESS;

EID: 0031790687     PISSN: 07488386     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1700(1998100)14:4<225::AID-SMI801>3.0.CO;2-P     Document Type: Conference Paper

References (45)

1. Anand-Srivastava, M. B. and Trachte, G. J. Atrial natriuretic factor receptors and signal transduction mechanisms. Pharm. Rev. 1993; 45: 455-497.
2. Espiner. E. A. Physiology of natriuretic peptides. J. Intern. Med. 1994; 235: 527-541.
3. Aguilera, G. Regulation of pituitary ACTH secretion during chronic stress. Front. Neuroendocrinol. 1994; 15: 321-350.
4. Kellner, M Wiedemann, K. and Holsboer, F. Atrial natriuretic factor inhibits the CRH-stimulated secretion of cortisol in man. Life Sci. 1992; 50: 835-1842.
5. Biro, E Gardi, J Vecsernyes, M. J. J Toth, G. and Telegdy, G. The effects of atrial natriuretic peptide (ANP 1-28) on corticotrophin releasing factor in brain of rats. Life Sci. 1996; 59: 1351-6.
6. Telegdy, G. The action of ANP, BNP and related peptides on motivated behaviour in rats. Rev. Neurosci. 1994:5: 309-315.
7. Biro, E Toth, G. and Telegdy, G. Involvement of neurotransmitters in the anxiolytic-like' action of atrial natriuretic peptide in rats. Neuropeptides 1995; 29:215-220.
8. Bhattacharya, S. K Chakrabarti, A Sandler, M. and Glover, V. Anxiolytic activity of intraventricularly administered atrial natriuretic peptide in the rat. Neuropsychopharmacologv 1996; 15: 199-206.
9. Sandier, M Clow, A Watkins, P. J. and Glover, V. Tribulin -an endocoid marker of anxiety in man. Stress Med. 1988; 4: 215-218.
10. Glover, V Halket, J. M Watkins, P. J Clow, A Goodwin, B. L. and Sandler, M. Isatin: Identity with the purified monoamine oxidase inhibitor tribulin. J. Neurochem. 1988; 51: 656-659.
11. Medvedev. A. E Goodwin, B. L Halket, J Sandier, M. and Glover, V. Monoamine oxidase A-inhibiting components of urinary tribulin: Purification and identification. ,J. Neural Transm. 1995; 9: 225-237.
12. Bohm, F Weitere Untersuchungen über die Bildung des Indolringes, ihnbesondere des Isatins. HoppeSeyler's Z. physiol. Chem. 1940; 265: 210-221.
13. Halket, J. M Watkins, P. J Przyborowska, A. et al. Isatin (indole-2,3-dione) in urine and tissues. Detection by mass spectrometry. J. Chromât. Biomed. Appl. 1991; 562: 279-287.
14. Manabe, S Gao, Q Yuan. J.. Takahashi. T. and Ueki, A. Determination of isatin in urine and plasma by high-performance liquid chromatography. ,J. Chromât. B. 1997:691: 197-202.
15. Glover. V.. Bhattacharya, S. K. and Sandler, M. Isatin a new biological factor. Indian J. Exp. Biol. 1991: 29: 1 5.
16. Watkins. P.. Clow. A Glover. V Halket. J Przyborowska, A. and Sandier, M. Isatin, regional distribution in rat brain and tissues. Neurochem. Int. 1990; 17: 321 323.
17. Glover, V. and Sandier, M. Tribulin and isatin: An update. In: Monoamine Oxidase: Basic and Clinical Frontiers. Yasuhara, H Parvez, S. H Oguchi, K Sandier. M. and Nagatsu, T. (Eds) VSP, Utrecht, 1993, pp. 61-71.
18. Sandier, M Przyborowska, A Halket, J. M Watkins, P Glover, V. and Coates, M. E. Urinary but not brain isatin levels are reduced in germ-free rats. .J. Neurochem. 1991; 57: 1074-1075.
19. Muller, M. Vergleichende pharmacologische Studien mit Indole und Isatin. Med. Exp. 1962; 7: 155-160.
20. Medvedev, A Goodwin, B Clow, A Halket, J Glover, V. and Sandler, M. Inhibitory potency of some isatin analogues on human monoamine oxidase A and B. Biochem. Pharmacol. 1992; 44: 590-592.
21. Medvedev, A. E Ivanov, A. S Kamyshanskaya, N. S. et al. Interaction of indole derivatives with monoamine oxidase A and B. Studies on the structure-inhibitory activity relationship. Biochem. Mol. Biol. Int. 1995; 36: 113-122.
22. Glover, V. Function of endogenous monoamine oxidase inhibitors (tribulin). J. Neural. Transm. Suppl. 1997; 52: 313-319.
23. Glover, V Medvedev, A. and Sandier, M. Isatin is a potent endogenous antagonist of guanylate cyclasecoupled atrial natriuretic peptide receptors. Life. Sci. 1995; 57: 2073-2079.
24. Medvedev, A. E Clow, A Sandler, M. and Glover, V. Isatin: A link between natriuretic peptides and rnonoamines? Biochem. Pharmacol. 1996; 52: 385-391.
25. Mclntyre, I. M. and Norman, T. R. Serotonergic effects of isatin: An endogenous MAO inhibitor related to tribulin. J. Neural Transm. (Gen. Sect.) 1990; 79: 35-40.
26. Bhattacharya, S. K. and Acharya, S. B. Further investigations on the anxiogenic effects of isatin. Biogen. Amines 1993; 9: 453-463.
27. Hamaue, N Minami, M Kanamaru, Y. et al. Identification of isatin, an endogenous MAO inhibitor, in the brain of stroke prone SHR rats. Biogen. Amines 1994; 10: 99-110.
28. Panova, N. G Zemskova, M. A Axenova, L. N. and Medvedev, A. E. Does isatin interact with rat brain monoamine oxidases in vivo? Neurosci. Lett. 1997; 233: 58-60.
29. Sareen, K Kohli, R. P Amma, M. K. P. and Gujrai, M. L. Anticonvulsant drugs based on the neurochemistry of seizures. Indian J. Phvsiol. Pharmacol. 1962; 6: 87-89.
30. Chocholova, L. and Kolinova, M. Effect of isatin (2,3-dioxoindoline) on audiogenic seizures in rats and its relationship to electrographic and behavioural phenomena. Physiol. Bohem. 1979; 28: 495-502.
31. Bhattacharya. S. K. and Chakrabarti, A. Doserelated proconvulsant and anticonvulsant activity of isatin, a putative biological factor, in rats. Indian J. Exp. Biol. 1998; 36; 118-121.
32. Bhattacharya, S. K Mitra, S. K. and Acharya. S. B. Anxiogenic activity of isatin, a putative biological factor, in rodents. J. Psychopharmacol. 1991; 5: 202-206.
33. Abel, E. L. Behavioural effects of isatin on open field activity and immobility in the forced swim test in rats. Physiol. Behav. 1995; 57: 611-613.
34. Palit, G Kumar, R Patnaik, G. K. and Bhattacharya, S. K. Behavioural effects of isatin, a putative biological factor, in rhesus monkeys. Biogen. Amines 1997; 13: 131-142.
35. Satyan, K. S Rai, A Jaiswal, A. K Acharya, S. B. and Bhattacharya, S. K. Isatin, a putative anxiogenic endocoid. induces memory dysfunction in rats. Indian J. Exp. Biol. 1995; 33: 576-579.
36. Hota. D. and Acharya, S. B. Studies on peripheral actions of isatin. Indian J. Exp. Biol. 1994; 32: 710-717.
37. Hamaue, N Minami. M.. Hirafuji, M. et al. Significance of isatin, an endogenous MAO inhibitor, on
38. blood pressure control and monoamine levels in rats. Biogen. Amines 1996; 12: 395-405.
39. Bhattacharya, S. K Chakrabarti, A Sandler, M. and Glover, V. Isatin inhibits the memory-facilitating effect of centrally administered atrial natriuretic peptide in rats. Med. Sci. Res. 1996; 24: 299-301.
40. Clow, A Davidson, J Glover, V. et al. Isatin and tribulin concentrations are increased in rabbit brain but not liver following pentylenetetrazole administration. Neurosci. Lett. 1989; 107: 327-330.
41. Bhattacharya, S. K Clow, A Przyborowska. A.. Halket, J.. Glover, V. and Sandler, M. Effect of aromatic amino acids, pentylene tetrazole and yohimbine on isatin and tribulin activity in rat brain. Neurosci. Lett. 1991: 132: 44-46.
42. Morley, J. E Farr, S. A. and Flood, J. F. Isatin inhibits food intake in mice. J. Pharmacol. 1996; 305: 23-29.
43. Brewerton, T. D Zealberg, J. Z Lydiard, R. B.. Glover, V Sandier, M. and Ballenger. J. C. CSF isatin is elevated in bulimia nervosa. Biol. Psvc/uat. 1995:37:481-483.
44. Chocholova, L. and Kolinova, M. Effect of isatin (2,3-dioxoindoline) on physiological and pathological electrographic manifestations and vigilance. PhysioJ. Bohem. 1981; 30: 129-137.
45. Medvedev, A. E Gorkin, V. Z Fedotova. V. Z Semiokhina, A. F Sandler, M. and Glover, V. Antiseizure effect of isatin and reduction of monoamine oxidase activity in rats with experimental audiogenic seizures. Med. Sci. Res. 1994; 22: 555-556.