Primary biliary cirrhosis. Is (and how much of) the pathology preventible?

Immunologic Research

Volumn 18, Issue 2, 1998, Pages 117-123

  Bar Dayan, Yaron ^a   Gershwin, M Eric ^b   Levi, Yaîr ^a   Amital, Howard ^a   Shoenfeld, Yehuda ^a,c  

^a TEL AVIV UNIVERSITY   (Israel)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SHEBA MEDICAL CENTER   (Israel)

Author keywords

Antimitochondrial antibodies; Prediction prevention; Primary biliary cirrhosis; Ursodeoxycholic acid

Indexed keywords

BILE ACID; MITOCHONDRION ANTIBODY; URSODEOXYCHOLIC ACID;

AUTOIMMUNE DISEASE; COST EFFECTIVENESS ANALYSIS; DIARRHEA; DISEASE COURSE; FATALITY; GASTROINTESTINAL SYMPTOM; HUMAN; LIVER TRANSPLANTATION; NAUSEA; PATHOGENESIS; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; REVIEW; VOMITING;

EID: 0031790320     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02788754     Document Type: Review

References (52)

1. Neuberger J: Primary biliary cirrhosis. Lancet 1997;350:875-879.
2. Kaplan MM: Primary biliary cirrhosis. N Engl J Med 1987;316:521-528.
3. Kaplan MM: Primary biliary cirrhosis. N Engl J Med 1996;335: 1570-1578.
4. Balasubramaniam K, Grambsch PM, Wiesner RH, Lindor KD, Dickson ER, Diminished survival in asymptomatic primary biliary cirrhosis, a prospective study. Gastroenterology 1990;98:1567-1571.
5. Mahl TC, Shockcor W, Boyer JL: Primary biliary cirrhosis, survival of a large cohort of symptomatic and asymptomatic patients followed for 24 yr. J Hepatol 1994;20:707-713.
6. Dickson ER, Reming TR, Wiesner RH, Baldus WP, Fleming CR, Ludwig J, McCall JT: Trial of penicillamine in primary biliary cirrhosis. N Engl J Med 1985;312:1011-1015.
7. Shoenfeld Y: Primary biliary cirrhosis and autoimmune rheumatic diseases, γ prediction and prevention. Isr J Med Sci, 1992;28:113-116.
8. Shoenfeld Y: What is going to happen as far as the prediction of autoimmune disorders is concerned? Ann Med Interne 1992;143:525-526.
9. James SP, Hoofnagle JH, Strober W, Jones EA: Primary biliary cirrhosis, a model autoimmune disease. Ann Intern Med 1983;99:500-512.
10. Rotman P, Levi Y, Shoenfeld Y: Primary biliary cirrhosis-association or overlap with other autoimmune diseases. Isr J Med Sci 1997;33:823-825.
11. Gulp KS, Fleming CR, Duffy J, Baldus WP, Dickson ER: Autoimmune association in primary biliary cirrhosis. Mayo Clin Proc 1982;57:365-370.
12. Zurgil N, Bakimer R, Kaplan M, Youinou P, Shoenfeld Y: Anti-pyruvate dehydrogenase autoantibodies in primary biliary cirrhosis. J Clin Immunol 1991;11:239-245.
13. Walker JG, Doniach D, Roitt IM, Sherlock S: Serological tests in diagnosis of primary biliary cirrhosis. Lancet 1965;1:827-830.
14. Van de Water J, Cooper A, Surh CD, Coppel R, Danner D, Ansari A, Dickson R, Gershwin ME: detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis. N Engl J Med 1989;320:1377-1380.
15. Konikoff F, Isenberg DA, Barrison I, Theodor E, Shoenfeld Y: Anti-nuclear autoantibodies in chronic liver diseases. Hepatogastroenterology 1989;36:341-345.
16. Elta GH, Sepersky RA, Goldberg MJ, Connors CM, Miller KB, Kaplan MM: Increased incidence of hypothyroidism in primary biliary cirrhosis. Dig Dis Sci 1983; 28:971-975.
17. Pares A, Martorell J, Caballeria J, Vives J, Bruguera M, Rodes J: Lymphocytotoxic antibodies in primary biliary cirrhosis. Dig Dis Sci 1985;30:829-833.
18. Sundewall AC, Lefvert AK, Olsson R: Antiacetylcholine receptor antibodies in primary biliary cirrhosis. Acta Med Scand 1985;217:519-525.
19. Bassendine MF, Collins JD, Stephenson J, Saunders P, James OF: Platelet associated immunoglobulins in primary biliary cirrhosis, a cause of thrombocytopenia ? Gut 1985;26:1074-1079.
20. Penner E: Demonstration of immune complexes containing the ribonucleoprotein antigen Ro in primary biliary cirrhosis. Gastroenterology 1986;90:724-727.
21. Konikoff F, Swissa M, Shoenfeld Y: Autoantibodies to histones and their subfractions in chronic liver diseases. Clin Immunol Immunopathol 1989;51:77-82.
22. Parveen S, Morshed SA, Nishioka M: High prevalence of antibodies to recombinant CENP-B in primary biliary cirrhosis, nuclear immunofluorescence patterns and ELISA reactivities. J Gastroenterol Hepatol 1995;10:438-445.
23. Miller KB, Elta GH, Rudders RA, Kaplan MM: Lymphocyte subsets in primary biliary cirrhosis. Ann Intern Med 1984;100:385-387.
24. James SP, Elson CO, Waggoner JG, Jones EA, Strober W: Deficiency of the autologous mixed lymphocyte reaction in patients with primary biliary cirrhosis. J Clin Invest 1980;66:1305-1310.
25. Moreno-Otero R, Civeira MP, Suou T, Kanof ME, James SP, Jones EA: Reduced numbers of CD8+ T cells and B cell expression of Leu-8 antigen in peripheral blood of patients with primary biliary cirrhosis. Hepatogastroenterology 1994; 41:239-243.
26. Menendez JL, Giron JA, Manzano L, Garrido A, Abreu L, Albillos A, Durontez A, Alvarez-Mon M: Deficient interleukin-2 responsiveness of T lymphocytes from patients with primary biliary cirrhosis. Hepatology 1992;16:931-936.
27. Spengler U, Moller A, Jung MC, Messer G, Zachoval G, Hoffmann RM, Eisenberg J, Paumgartner G, Riethmuller G, Weiss EH: T lymphocytes from patients with primary biliary cinhosis produce reduced amounts of lymphotoxins, tumor necrosis factor and interferon -gamma upon mitogen stimulation. J Hepatol 1992;15:129-135.
28. Van de Water J, Ansari AA, Surh CD, Coppel R, Roche T, Bonkovsky H, Kaplan M, Gershwin ME: Evidence for the targeting by 2-oxodehydrogenase enzymes in the T cell response of primary biliary cirrhosis. J Immunol 1991;146:89-94.
29. Jones DE, Palmer JM, James OF, Yeaman SJ, Bassendine MF, Diamond AG: T-cell responses to the components of pyruvate dehydrogenase complex in primary biliary cirrhosis. Hepatology 1995;21: 995-1002.
30. Miyamoto T, Maeda T, Onishi S, Yamamoto Y: T-cell autoreactivity against a 28 kD biliary protein (B1-p28) in primary biliary cirrhosis. J Hepatol 1995;22:423-430.
31. Munoz LE, Thomas HC, Scheurer JP, Doniach D, Sherlock S: Is mitochondrial antibody diagnostic of primary biliary cirrhosis? Gut 1981;22:136-140.
32. Berg PA, Klein R, Lindenborn-Ponitus J: Antimitochondrial antibodies in primary biliary cirrhosis. J Hepatol 1986;2:123-128.
33. Gershwin ME, Coppel RI, Mackay IR: Primary biliary cirrhosis and mitochondrial autoantigens-insights from molecular biology. Hepatology 1988;8:147-151.
34. Zurgil N, Konikof F, Bakimer R, Slor H, Shoenfeld Y: Detection of antimitochondrial antibodies:characterization by enzyme immunoassay and immunoblotting. Autoimmunity 1989;4:289-297.
35. Berg PA, Klein R: Molecular determination of primary biliary cirrhosis specific M2 antigen. Hepatology 1988;8:200-201.
36. Gershwin ME, Mackay IR, Sturgess A, Coppel R: Identification and specificity of cDNA encoding the 70 Kd mitochondrial antigen recognized in primary biliary cirrhosis. J Immunol 1987;138:3525-3531.
37. Yeaman SJ, Danner DJ, Muriner DJ, Gussey SPM, James OFW, Bassendine MF: PBC, identification of two major M2 mitochondrial autoantigens. Lancet 1988; 1:1067-1069.
38. Fussey SPM, Guest JR, James OFW, Bassendine MF, Yeaman SJ: Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Proc Natl Acad Sci USA 1988;85:8654-8658.
39. Surh CD, Roche TE, Danner DJ, Ansari A, Coppel RL, Prindiville T, Dickson ER, Gershwin ME: Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross reactive epitopes on protein x and dihydrolipoamide acyltransferase of pyruvate dehydrogenase complex. Hepatology 1989;10:127-133.
40. Fregeau DR, Roche TE, Davis PA, Coppel R, Gershwin ME: Inhibition of pyruvate-dehydrogenase activity by autoantibodies specific for E1a, a non-lipoic acid containing mitochondrial enzyme. J Immunol 1990;144:1671-1676.
41. Fregeau DR, Leung PS, Coppel RI, McNeilage LJ, Medsger TA Jr, Gershwin ME: Autoantibodies to mitochondria in systemic sclerosis. Frequency and characterization using recombinant cloned autoantigen. Arthritis Rheum 1988;31:386-392.
42. Amital H, Swissa M, Bar-Dayan Y, Buskila D, Shoenfeld Y: New therapeutic avenues in autoimmunity. Res Immunol 1996;147:361-376.
43. Pasha T, Heathcote J, Cauchdudek K: Cost effectiveness of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1996,24:169 (abstract).
44. Yoshikawa M, Tsujii T, Matsumura K, Yamao J, Matsumura Y, Kubo R, Fukui H, Ishizaka S: Immunomodulatory effects of ursodeoxycholic acid on immune responses. Hepatology 1992;16:358-364.
45. Tanaka H, Makino Y, Miura T, Hirano F, Okamoto K, Komura K, Sato Y, Makino I: Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class Il gene expression via a glucocorticoid receptor-dependent pathway. J Immunol 1996;156:1601-1608.
46. Poupon RE, Poupon R, Baikau B, UDCA-PBC Study Group: Ursodiol for the long-term treatment of primary biliary cirrhosis. N Engl J Med 1994;330:1342-1347.
47. Lindor KD, Dickson ER, Baldus WP, Jorgensen RA, Ludwig J, Martaugh PA, Harrison JM, Wiesner RH, Anderson ML, Lange SM, et al.: Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 1994;106:1284-1290.
48. Heathcote EJ, Cauch-Dudek K, Walker V, Bailey RJ, Blendis LM, Ghent CN, Michieletti P, Minuk GY, Pappas SC, Scully LJ, et al.: The Canadian multicenter double-blind randomized controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1994;19:1149-1156.
49. Combes B, Carithers RL Jr, Maddrey WC, Lin D, McDonald MF, Wheeler DE, Eigenbrodt EH, Munoz SJ, Rubin R, Garcia-Tsao G, et al.: A randomized double blind placebo controlled trial of ursodeoxycholic acid in primary biliary cirrhosis. Hepatology 1995;22: 759-766.
50. Carithers R, Luketic V, Peters M: Extended follow up of patients in the US multi-center trial of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology 1996; 110:Suppl A1163 (abstract).
51. Poupon RE, Lindor KD, Cauch-Dudek K, Dickson ER, Poupon R, Heathcote EJ: Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology 1997;113:884-890.
52. Beuers U, Kullak-Ublick G, Paumgartner G: Mechanism of action of UDCA in cholestatic syndromes, in Alvaro D, Benedetti A, Strazzabosco M (eds.): Vanishing Bile Duct Syndrome - Pathophysiology and Treatment. Dordrecht Kluwer Academic Publishers, 1997, pp 230-239.