메뉴 건너뛰기




Volumn 63, Issue 11, 1998, Pages 608-614

Inhibition studies of dehydroepiandrosterone 7α- and 7β-hydroxylation in mouse liver microsomes

Author keywords

7 hydroxylation; 7 hydroxylation; Cytochromes P450; Dehydroepiandrosterone; Mouse liver microsomes

Indexed keywords

ALPHA NAPHTHOFLAVONE; ANDROSTENEDIOL; ANDROSTENEDIONE; CARBON 14; CHLORAMPHENICOL; CORTICOSTERONE; CYTOCHROME P450; ENZYME INHIBITOR; EPIANDROSTERONE; FURAFYLLINE; KETOCONAZOLE; METYRAPONE; PHENAZONE; PRASTERONE; PREGNENOLONE; PROGESTERONE; QUINIDINE; STEROID; TESTOSTERONE;

EID: 0031788908     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(98)00071-3     Document Type: Article
Times cited : (32)

References (42)
  • 1
  • 2
    • 0021112308 scopus 로고
    • 19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes
    • 19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes. J Biol Chem. 258:1983;8839-8847.
    • (1983) J Biol Chem , vol.258 , pp. 8839-8847
    • Wood, A.W.1    Ryan, D.E.2    Thomas, P.E.3    Levin, W.J.4
  • 3
    • 0023643411 scopus 로고
    • Regioselective progesterone hydroxylation catalyzed by eleven rat hepatic cytochrome P-450 isozymes
    • Swinney D.C., Ryan D.E., Thomas P.E., Levin W. Regioselective progesterone hydroxylation catalyzed by eleven rat hepatic cytochrome P-450 isozymes. Biochemistry. 26:1987;7073-7083.
    • (1987) Biochemistry , vol.26 , pp. 7073-7083
    • Swinney, D.C.1    Ryan, D.E.2    Thomas, P.E.3    Levin, W.4
  • 4
    • 0024584510 scopus 로고
    • Purification of two isozymes of rat liver microsomal cytochrome P450 with testosterone 7α-hydroxylase activity
    • Arlotto M.P., Greenway D.J., Parkinson A. Purification of two isozymes of rat liver microsomal cytochrome P450 with testosterone 7α-hydroxylase activity. Arch Biochem Biophys. 270:1989;441-457.
    • (1989) Arch Biochem Biophys , vol.270 , pp. 441-457
    • Arlotto, M.P.1    Greenway, D.J.2    Parkinson, A.3
  • 5
    • 0002432728 scopus 로고
    • 7-Hydroxylation of dehydroepiandrosterone by rat-liver homogenante
    • Stárka L., Kutová J. 7-Hydroxylation of dehydroepiandrosterone by rat-liver homogenante. Biochim Biophys Acta. 56:1962;76-82.
    • (1962) Biochim Biophys Acta , vol.56 , pp. 76-82
    • Stárka, L.1    Kutová, J.2
  • 6
    • 0014303429 scopus 로고
    • Characterization of microsomal dehydroepiandrosterone 7-hydroxylase from rat liver
    • Sulcova J., Stárka L. Characterization of microsomal dehydroepiandrosterone 7-hydroxylase from rat liver. Steroids. 12:1968;113-126.
    • (1968) Steroids , vol.12 , pp. 113-126
    • Sulcova, J.1    Stárka, L.2
  • 9
    • 0030273492 scopus 로고    scopus 로고
    • Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7α-hydroxylation in mouse tissues
    • Doostzadeh J., Morfin R. Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7α-hydroxylation in mouse tissues. Steroids. 61:1996;613-620.
    • (1996) Steroids , vol.61 , pp. 613-620
    • Doostzadeh, J.1    Morfin, R.2
  • 10
    • 0022770127 scopus 로고
    • Cytochromes P-450 and the regulation of steroid synthesis
    • Hall P.F. Cytochromes P-450 and the regulation of steroid synthesis. Steroids. 48:1986;131-196.
    • (1986) Steroids , vol.48 , pp. 131-196
    • Hall, P.F.1
  • 11
    • 0030572961 scopus 로고    scopus 로고
    • Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine
    • Li P.K., Rhodes M.E., Burke A.M., Johnson D.A. Memory enhancement mediated by the steroid sulfatase inhibitor (p-O-sulfamoyl)-N-tetradecanoyl tyramine. Life Sci. 60:1997;45-51.
    • (1997) Life Sci , vol.60 , pp. 45-51
    • Li, P.K.1    Rhodes, M.E.2    Burke, A.M.3    Johnson, D.A.4
  • 12
    • 0028206488 scopus 로고
    • Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice
    • Morfin R., Courchay G. Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice. J Steroid Biochem Molec Biol. 50:1994;91-100.
    • (1994) J Steroid Biochem Molec Biol , vol.50 , pp. 91-100
    • Morfin, R.1    Courchay, G.2
  • 13
    • 0030436261 scopus 로고    scopus 로고
    • Pregnenolone-7β-hydroxylating activities of yeast-expressed mouse cytochrome P450-1A1 and mouse-tissue microsomes
    • Doostzadeh J., Urban P., Pompon D., Morfin R. Pregnenolone-7β-hydroxylating activities of yeast-expressed mouse cytochrome P450-1A1 and mouse-tissue microsomes. Eur J Biochem. 242:1996;641-647.
    • (1996) Eur J Biochem , vol.242 , pp. 641-647
    • Doostzadeh, J.1    Urban, P.2    Pompon, D.3    Morfin, R.4
  • 14
    • 0014036173 scopus 로고
    • Effect of phenobarbital treatment on liver microsomal metabolism and uterotropic action of 17β-estradiol
    • Levin W., Welch R.M., Conney A.H. Effect of phenobarbital treatment on liver microsomal metabolism and uterotropic action of 17β-estradiol. Endocrinology. 80:1967;135-140.
    • (1967) Endocrinology , vol.80 , pp. 135-140
    • Levin, W.1    Welch, R.M.2    Conney, A.H.3
  • 15
    • 0014250661 scopus 로고
    • Effect of phenobarbital and other drugs on the metabolism and uterotropic action of estradiol-17β and estrone
    • Levin W., Welch R.M., Conney A.H. Effect of phenobarbital and other drugs on the metabolism and uterotropic action of estradiol-17β and estrone. J Pharmacol Exp Ther. 159:1968;362-371.
    • (1968) J Pharmacol Exp Ther , vol.159 , pp. 362-371
    • Levin, W.1    Welch, R.M.2    Conney, A.H.3
  • 16
    • 0014034748 scopus 로고
    • Insecticide inhibition and stimulation of steroid hydroxylases in rat liver
    • Welch R.M., Levin W., Conney A.H. Insecticide inhibition and stimulation of steroid hydroxylases in rat liver. J Pharmacol Exp Ther. 155:1967;167-173.
    • (1967) J Pharmacol Exp Ther , vol.155 , pp. 167-173
    • Welch, R.M.1    Levin, W.2    Conney, A.H.3
  • 17
    • 0014266954 scopus 로고
    • Stimulatiry effect of phenobarbital on metabolism in vivo of estradiol-17β- And estrone in the rat
    • Welch R.M., Levin W., Conney A.H. Stimulatiry effect of phenobarbital on metabolism in vivo of estradiol-17β- and estrone in the rat. J. Pharmacol. Exp. Ther. 160:1968;171-178.
    • (1968) J. Pharmacol. Exp. Ther. , vol.160 , pp. 171-178
    • Welch, R.M.1    Levin, W.2    Conney, A.H.3
  • 18
    • 0015081666 scopus 로고
    • Effect of halogenated hydrocarbon insecticides on metabolism and uterotropic action of estrogens in rats and mice
    • Welch R.M., Levin W., Kuntzman R., Jacobson M., Conney A.H. Effect of halogenated hydrocarbon insecticides on metabolism and uterotropic action of estrogens in rats and mice. Toxicol Appl Pharmacol. 19:1971;234-246.
    • (1971) Toxicol Appl Pharmacol , vol.19 , pp. 234-246
    • Welch, R.M.1    Levin, W.2    Kuntzman, R.3    Jacobson, M.4    Conney, A.H.5
  • 19
    • 0013818005 scopus 로고
    • Effect of drugs and insecticides on the anesthetic action of steroids
    • Kuntzman R., Sansur M., Conney A.H. Effect of drugs and insecticides on the anesthetic action of steroids. Endocrinology. 77:1965;952-954.
    • (1965) Endocrinology , vol.77 , pp. 952-954
    • Kuntzman, R.1    Sansur, M.2    Conney, A.H.3
  • 20
    • 0013973233 scopus 로고    scopus 로고
    • Decreased central depressant effect of progesterone and other steroids in rats pretreated with drugs and insecticides
    • Conney A.H., Jacobson M., Levin W., Schneidman K., Kuntzman R. Decreased central depressant effect of progesterone and other steroids in rats pretreated with drugs and insecticides. J Pharmacol Exp Ther. 154:1996;310-318.
    • (1996) J Pharmacol Exp Ther , vol.154 , pp. 310-318
    • Conney, A.H.1    Jacobson, M.2    Levin, W.3    Schneidman, K.4    Kuntzman, R.5
  • 21
    • 0242714438 scopus 로고
    • Increased activity of androgen hydroxylases in liver microsomes of rats pretreated with phenobarbital and other drugs
    • Conney A.H., Klutch A. Increased activity of androgen hydroxylases in liver microsomes of rats pretreated with phenobarbital and other drugs. J Biol Chem. 238:1963;1611-1617.
    • (1963) J Biol Chem , vol.238 , pp. 1611-1617
    • Conney, A.H.1    Klutch, A.2
  • 22
    • 0016031612 scopus 로고
    • Increased liver microsomal androgen metabolism by phenobarbital: Correlation with decreased androgen action on seminal vesicles of the rat
    • Levin W., Welch R.M., Conney A.H. Increased liver microsomal androgen metabolism by phenobarbital correlation with decreased androgen action on seminal vesicles of the rat . J Pharmacol Exp Ther. 188:1974;287-292.
    • (1974) J Pharmacol Exp Ther , vol.188 , pp. 287-292
    • Levin, W.1    Welch, R.M.2    Conney, A.H.3
  • 23
    • 0013781880 scopus 로고
    • Induction of liver microsomal cortisol 6β-hydroxylase by diphenyl-hydantoin or phenobarbital: An explanation for increased excretion of 6-hydroxycortisol in human treated with these drugs
    • Conney A.H., Jacobson M., Schneidman K., Kuntzman R. Induction of liver microsomal cortisol 6β-hydroxylase by diphenyl-hydantoin or phenobarbital An explanation for increased excretion of 6-hydroxycortisol in human treated with these drugs . Life Sci. 4:1965;1091-1098.
    • (1965) Life Sci , vol.4 , pp. 1091-1098
    • Conney, A.H.1    Jacobson, M.2    Schneidman, K.3    Kuntzman, R.4
  • 24
    • 0031840780 scopus 로고    scopus 로고
    • Hydroxylation of pregnenolone at the 7α- And 7β-positions by mouse liver microsomes. Effects of cytochrome p450 inhibitors and structure-specific inhibition by steroid hormones
    • Doostzadeh J., Cotillon A.C., Morfin R. Hydroxylation of pregnenolone at the 7α- and 7β-positions by mouse liver microsomes. Effects of cytochrome p450 inhibitors and structure-specific inhibition by steroid hormones. Steroids. 63:1998;383-392.
    • (1998) Steroids , vol.63 , pp. 383-392
    • Doostzadeh, J.1    Cotillon, A.C.2    Morfin, R.3
  • 27
    • 0003112774 scopus 로고
    • In vitro metabolic transformations of 7α-hydroxy-dehydroepiandrosterone in rat liver adrenal and testis
    • Hampl R., Stárka L. In vitro metabolic transformations of 7α-hydroxy-dehydroepiandrosterone in rat liver adrenal and testis. Endocrinol Exp. 1:1967;5-13.
    • (1967) Endocrinol Exp , vol.1 , pp. 5-13
    • Hampl, R.1    Stárka, L.2
  • 28
    • 0013563671 scopus 로고
    • 19 steroid allylic alcohols by rat liver preparations
    • 19 steroid allylic alcohols by rat liver preparations. J Steroid Biochem. 1:1969;47-56.
    • (1969) J Steroid Biochem , vol.1 , pp. 47-56
    • Hampl, R.1    Stárka, L.2
  • 29
    • 0030845921 scopus 로고    scopus 로고
    • Identification and characterization of a mouse oxysterol 7α-hydroxylase cDNA
    • Schwarz M., Lund E.G., Lathe R., Björkhem I., Russell D.W. Identification and characterization of a mouse oxysterol 7α-hydroxylase cDNA. J Biol Chem. 272:1997;23995-24001.
    • (1997) J Biol Chem , vol.272 , pp. 23995-24001
    • Schwarz, M.1    Lund, E.G.2    Lathe, R.3    Björkhem, I.4    Russell, D.W.5
  • 32
    • 0023605832 scopus 로고
    • Selective inactivation by chloramphenicol of the major phenobarbital-inducible isozyme of dog liver cytochrome P450
    • Ciaccio P.J., Duignan D.B., Halpert J.R. Selective inactivation by chloramphenicol of the major phenobarbital-inducible isozyme of dog liver cytochrome P450. Drug Metab Disp. 15:1987;852-856.
    • (1987) Drug Metab Disp , vol.15 , pp. 852-856
    • Ciaccio, P.J.1    Duignan, D.B.2    Halpert, J.R.3
  • 33
    • 0027380074 scopus 로고
    • Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
    • Kunze K.L., Trager W.F. Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chem Res Toxicol. 6:1993;649-656.
    • (1993) Chem Res Toxicol , vol.6 , pp. 649-656
    • Kunze, K.L.1    Trager, W.F.2
  • 34
    • 0024376244 scopus 로고
    • Distribution and regulation of 5α-androstane-3β,17β-diol hydroxylase in the rat central nervous system
    • Warner M., Strömstedt M., Möller L., Gustafsson J.Å. Distribution and regulation of 5α-androstane-3β,17β-diol hydroxylase in the rat central nervous system. Endocrinolgy. 124:1989;2699-2706.
    • (1989) Endocrinolgy , vol.124 , pp. 2699-2706
    • Warner, M.1    Strömstedt, M.2    Möller, L.3    Gustafsson, J.Å.4
  • 35
    • 0027055261 scopus 로고
    • Neurosteroid metabolism: 7α-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes
    • Akwa Y., Morfin R., Robel P., Baulieu E.E. Neurosteroid metabolism 7α-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes . Biochem J. 288:1992;959-964.
    • (1992) Biochem J , vol.288 , pp. 959-964
    • Akwa, Y.1    Morfin, R.2    Robel, P.3    Baulieu, E.E.4
  • 36
    • 0031283159 scopus 로고    scopus 로고
    • Dehydroepiandrosterone 7α- And 7β-hydroxylation in mouse brain microsomes. Effects of cytochrome P450 inhibitors and structure-specific inhibition by steroid hormones
    • Doostzadeh J., Cotillon A.C., Morfin R. Dehydroepiandrosterone 7α- and 7β-hydroxylation in mouse brain microsomes. Effects of cytochrome P450 inhibitors and structure-specific inhibition by steroid hormones. J Neuroendocrinol. 9:1997;923-928.
    • (1997) J Neuroendocrinol , vol.9 , pp. 923-928
    • Doostzadeh, J.1    Cotillon, A.C.2    Morfin, R.3
  • 37
    • 0030720779 scopus 로고    scopus 로고
    • Effects of cytochrome P450 inhibitors and of steroid hormones on the formation of 7-hydroxylated metabolites of pregnenolone in mouse brain microsomes
    • Doostzadeh J., Morfin R. Effects of cytochrome P450 inhibitors and of steroid hormones on the formation of 7-hydroxylated metabolites of pregnenolone in mouse brain microsomes. J Endocrinol. 155:1997;343-350.
    • (1997) J Endocrinol , vol.155 , pp. 343-350
    • Doostzadeh, J.1    Morfin, R.2
  • 38
    • 0024269576 scopus 로고
    • Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome P-450 3c
    • Johnson E.F., Schwab G.E., Vickery L.E. Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome P-450 3c. J Biol Chem. 263:1988;17672-17677.
    • (1988) J Biol Chem , vol.263 , pp. 17672-17677
    • Johnson, E.F.1    Schwab, G.E.2    Vickery, L.E.3
  • 39
    • 0023949862 scopus 로고
    • Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflovone
    • Schwab G.E., Raucy J.L., Johnson E.F. Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflovone. Molec Pharmacol. 33:1988;493-499.
    • (1988) Molec Pharmacol , vol.33 , pp. 493-499
    • Schwab, G.E.1    Raucy, J.L.2    Johnson, E.F.3
  • 40
    • 0028307539 scopus 로고
    • Activation of CYP3A4: Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site
    • Shou M., Grogan J., Mancewicz J.A., Krausz K.W., Gonzalez F.J., Gelboin H.V., Korzekwa K.R. Activation of CYP3A4 Evidence for the simultaneous binding of two substrates in a cytochrome P450 active site . Biochemistry. 33:1994;6450-6455.
    • (1994) Biochemistry , vol.33 , pp. 6450-6455
    • Shou, M.1    Grogan, J.2    Mancewicz, J.A.3    Krausz, K.W.4    Gonzalez, F.J.5    Gelboin, H.V.6    Korzekwa, K.R.7
  • 41
    • 0017644411 scopus 로고
    • Precursors for 6ξ and 7α-hydroxylation of 5α-androstane-3β-,17β-diol by human normal and hyperplastic prostate
    • Morfin R., Di Stefano S., Charles J.F., Floch H.H. Precursors for 6ξ and 7α-hydroxylation of 5α-androstane-3β-,17β-diol by human normal and hyperplastic prostate. Biochimie. 59:1977;637-644.
    • (1977) Biochimie , vol.59 , pp. 637-644
    • Morfin, R.1    Di Stefano, S.2    Charles, J.F.3    Floch, H.H.4
  • 42
    • 0020427547 scopus 로고
    • Studies on the 5α-androstane-3β,17β-diol-6α-hydroxylase and on the 5α-androstane-3β,17β-diol-7α-hydroxylase in anterior hypophysis of male rats
    • Guiraud J.M., Samperez S., Jouan P. Studies on the 5α-androstane-3β,17β-diol-6α-hydroxylase and on the 5α-androstane-3β,17β-diol-7α-hydroxylase in anterior hypophysis of male rats. Steroids. 40:1982;625-639.
    • (1982) Steroids , vol.40 , pp. 625-639
    • Guiraud, J.M.1    Samperez, S.2    Jouan, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.