Mechanism of block by tedisamil of transient outward current in human ventricular subepicardial myocytes

British Journal of Pharmacology

Volumn 125, Issue 4, 1998, Pages 659-666

  Wettwer, Erich ^a   Himmel, Herbert M ^a   Amos, Gregory J ^a,b   Li, Qi ^a,c   Metzger, Franz ^a,d   Ravens, Ursula ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b ASTRAZENECA R AND D   (Sweden)

^c Städt Klinikum ^*  (Canada)

^d Klinikum   (Germany)

Author keywords

Human cardiac myocytes; I(to) tedisamil; Transient outward current; Use dependent block; Voltage clamp

Indexed keywords

CALCIUM ION; SODIUM ION; TEDISAMIL;

ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG BINDING; DRUG MECHANISM; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MEMBRANE CURRENT; PRIORITY JOURNAL; SIMULATION; SODIUM CURRENT; VOLTAGE CLAMP;

ACTION POTENTIALS; ANTI-ARRHYTHMIA AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; CALCIUM; CYCLOPROPANES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART BLOCK; HEART VENTRICLES; HUMANS; MYOCARDIUM; POTASSIUM CHANNEL BLOCKERS; SODIUM; TIME FACTORS;

EID: 0031785347     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702110     Document Type: Article

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