Effects on skeletal muscle amino acids and whole body nitrogen metabolism of total parenteral nutrition following laparoscopic cholecystectomy and given to healthy volunteers

Clinical Nutrition

Volumn 17, Issue 5, 1998, Pages 205-210

  Hammarqvist, F ^a   Jacks, J ^b   Wernerman, J ^b  

^a ST GÖRAN S HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Amino acids; Parenteral nutrition; Protein metabolism; Skeletal muscle; Surgery

Indexed keywords

AMINO ACID; GLUTAMINE; MUSCLE PROTEIN; NITROGEN;

ADULT; ARTICLE; CATABOLISM; CHOLECYSTECTOMY; CLINICAL ARTICLE; CLINICAL TRIAL; HUMAN; LAPAROSCOPIC SURGERY; NITROGEN BALANCE; NITROGEN METABOLISM; POLYSOME; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RIBOSOME; SKELETAL MUSCLE; TOTAL PARENTERAL NUTRITION;

EID: 0031784867     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0261-5614(98)80060-5     Document Type: Article

References (30)

1. Clowes G H A, Randell H T, Cha C-J 1980 Amino acid and energy metabolism in septic and traumatized patients. JPEN 4: 195-203
2. Souba W W, Smith R J, Wilmore D W 1985 Glutamine metabolism by the intestinal tract. JPEN 9: 608-617
3. Wilmore D W, Smith R J, O'Dwyer S T et al 1988 The gut: a central organ after surgical stress. Surgery 104: 917-923
4. Vinnars E, Bergström J, Fürst P 1975 Influence of the postoperative state on the intracellular free amino acids in human muscle tissue. Ann Surg 182: 665-671
5. Cuthbertson D P 1932 Observations on the disturbance of metabolism produced by injury to the limbs. Quart J Med 25: 233-246
6. Hammarqvist F 1989 Intravenous amino acid supply after trauma: the effects of glutamine on muscle protein metabolism. Thesis. Karolinska Institute, Stockholm, Sweden
7. Wernerman J, von der Decken A, Vinnars E 1986 Protein synthesis in skeletal muscle in relation to nitrogen balance after abdominal surgery. The effect of total parenteral nutrition. JPEN 10: 578-582
8. Essén P, McNurlan M A, Wernerman J et al 1992 Uncomplicated surgery, but not general anesthesia, decreases muscle protein synthesis. Am J Physiol 262: E253-E260
9. Jorfeldt L 1985 A standardized human model of moderate trauma: Quantitative studies of glucose turnover during cholecystectomy. Acta Chir Scand 151 suppl 522: 57-85
10. Essén P, Thorell A, McNurlan M A et al 1995 Laparoscopic cholecystectomy does not prevent the postoperative protein catabolic response in muscle. Ann Surg 222: 36-42
11. Hammarqvist F, Westman B, Leijonmarck C-E et al 1996 Decrease in muscle glutamine, ribosomes, and the nitrogen losses are similar after laparoscopic compared with open cholecystectomy during the immediate postoperative period. Surgery 119: 417-423
12. Hammarqvist F, Wernerman J, Ali M R, Vinnars E 1990 Effects of an amino acid solution enriched with either branched chain amino acids or ornithine-alpha-ketoglutarate on the postoperative intracellular amino acid concentration of skeletal muscle. Br J Surg 77: 214-218
13. Setaro F, Morley C G D 1976 A modified fluorometric method for the determination of microgram quantities of DNA from cell or tissue cultures. Ann Biochem 71: 313-317
14. Fleck A 1967 The determination of organic nitrogen. Proc Ass Clin Biochem 4: 212-215
15. Snedecor G W, Cochran W G In: Ames I A. Statistical Methods, 7th Ed. 141-143
16. Hammarqvist F, Luo J-L, Andersson K, Wernerman J 1997 Skeletal muscle glutathione is depleted in critically ill patients. Crit Care Med 25: 78-84
17. Gamrin L, Essén P, Hultman E, Wernerman J 1996 A descriptive study of skeletal muscle metabolism in critically ill patients: free amino acids, energy rich phosphates, protein, nucleic acids, fat, water and electrolytes. Crit Care Med 24: 575-583
18. Andersson K, Luo J-L, Hammarqvist F, Wernerman J 1994 The effect of fasting on muscle glutathione levels. Clinical Nutrition 13: O.12 (suppl 1)
19. Askanazi J, Carpentier Y A, Michelsen C B et al 1980 Muscle and plasma amino acids following injury: influence of intercurrent infection. Ann Surg 191: 78-85
20. Sjölin J, Stjernström H, Henneberg S et al 1989 Splanchnic and peripheral release of 3-methylhistidine in relation to its urinary excretion in human infection. Metabolism 38: 23-29
21. Souba W W, Herskowitz K, Klimberg S V et al 1990 The effects of sepsis and endotoxemia on gut glutamine metabolism. Ann Surg 211: 543-551
22. Herskowitz K, Souba W W 1990 Intestinal glutamine metabolism during critical illness: a surgical perspective. Nutrition 6: 199-206
23. Hammarqvist F, Wernerman J, Ali M R et al 1989 Addition of glutamine to total parenteral nutrition after elective abdominal surgery spares free glutamine in muscle, counteracts the fall in muscle protein synthesis, and improves nitrogen balance. Ann Surg 209: 455-461
24. Hammarqvist F, Wernerman J, von der Decken A, Vinnars E 1990 Alanyl-glutamine counteracts the depletion of free glutamine and the decline in protein synthesis postoperatively in skeletal muscle. Ann Surg 212: 637-644
25. Hammarqvist F, Wernerman J, von der Decken A, Vinnars E 1991 An addition of alpha-ketoglutarate to total parenteral nutrition given following elective abdominal surgery improves nitrogen balance, counteracts the fall in protein synthesis and spares intracellular free glutamine in skeletal muscle. Surgery 109: 28-36
26. Essén P, Wernerman J, Sonnenfeld T et al 1992 Free amino acids in plasma and muscle during 24 hours postoperatively - a descriptive study. Clin Physiol 12: 165-179
27. Essén P, McNurlan M A, Gamrin L et al 1998 Tissues protein synthesis rate in critically ill patients. Crit Care Med 26: 92-100
28. Aulick L H, Wilmore D W 1979 Increased peripheral amino acid release following burn injury. Surgery 85: 560-565
29. Hammarqvist F, von der Decken A, Vinnars E 1994 Stress hormone and amino acid infusion in healthy volunteers; short term effects on protein synthesis and amino acid metabolism in skeletal muscle. Metabolism 43: 1158-1163
30. Wernerman J, Botta D, Hammarqvist F et al 1989 Stress hormones given to healthy volunteers alter the concentration and configuration of ribosomes in skeletal muscle reflecting changes in protein synthesis. Clin Sci 77: 611-616