Interaction of the dopamine D2 receptor agonist quinpirole with sympathetic vasomotor tone and the central action of rilmenidine in conscious rabbits

Journal of the Autonomic Nervous System

Volumn 72, Issue 2-3, 1998, Pages 187-194

  Van Den Buuse, Maarten ^a   Tritton, Scott B ^a   Burke, Sandra L ^a   Head, Geoffrey A ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

Blood pressure; Desensitisation; Heart rate; Quinpirole; Renal sympathetic nerve activity; Rilmenidine

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; DOPAMINE 2 RECEPTOR STIMULATING AGENT; METHYLDOPA; NORADRENALIN; QUINPIROLE; RILMENIDINE;

ADRENALIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD PRESSURE; BLOOD VESSEL TONE; CONFERENCE PAPER; CONTROLLED STUDY; DESENSITIZATION; FEMALE; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY NERVE; MALE; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRESSOR RESPONSE; PRIORITY JOURNAL; RABBIT; SYMPATHETIC TONE;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; BLOOD PRESSURE; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART RATE; KIDNEY; MALE; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; OXAZOLES; QUINPIROLE; RABBITS; RECEPTORS, DOPAMINE D2; SYMPATHETIC NERVOUS SYSTEM;

EID: 0031784113     PISSN: 01651838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1838(98)00104-0     Document Type: Conference Paper

References (29)

1. Dorward, P.K., Riedel, W., Burke, S.L., Gipps, J., Korner, P.I., 1985. The renal sympathetic baroreflex in the rabbit. Arterial and cardiac baroreceptor influences, resetting, and effect of anesthesia. Circ. Res. 57, 618-633.
2. Goiny, M., Lagercrantz, H., Srinivasan, M., Ungerstedt, U., Yamamoto, Y., 1991. Hypoxia-mediated in vivo release of dopamine in nucleus tractus solitarii of rabbits. J. Appl. Physiol. 70, 2395-2400.
3. Goldberg, L.I., Kohli, J.D., 1983. Peripheral dopamine receptors: a classification based on potency series and specific antagonism. Trends Pharmacol. Sci. 4, 64-66.
4. Gomez, R.E., Ernsberger, P., Feinland, G., Reis, D.J., 1991. Rilmenidine lowers blood pressure via imidazole receptors in brainstem C1 area. Eur. J. Pharmacol. 195, 181-191.
5. Head, G.A., De Jong, W., 1986. Differential blood pressure responses to intracisternal clonidine, α-methyldopa, and 6-hydroxydopamine in conscious normotensive and spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 8, 735-742.
6. Head, G.A., Burke, S.L., 1997. Relative importance of medullary brain nuclei for the sympatho-inhibitory actions of rilmenidine in the anaesthetised rabbit. J. Hypertens. 16, 503-517.
7. Head, G.A., Burke, S.L., Sannajust, F., 1994. Subretrofacial nucleus (SN) mediates rilmenidine-induced inhibition of the renal sympathetic baroreflex in rabbits. Can. J. Physiol. Pharmacol. 72, 369.
8. Laduron, P.M., Leysen, J.M., 1979. Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity. Biochem. Pharmacol. 28, 2161-2165.
9. Lahlou, S., Demenge, P., 1993. Cardiovascular responses to intrathecal dopamine receptor agonists after spinal transection in conscious rats. Cardiovasc. Res. 27, 222-230.
10. Lahlou, S., Petitjean, P., Pellissier, G., Mouchet, P., Feuerstein, C., Demenge, P., 1990. Rostrocaudal localization of cardiovascular responses induced by intrathecal administration of apomorphine in conscious, freely moving rats. J. Cardiovasc. Pharmacol. 16, 331-337.
11. Malpas, S.C., 1995. A new model for the generation of sympathetic nerve activity. Clin. Exp. Pharmacol. Physiol. 22, 11-15.
12. Malpas, S.C., Bendle, R.D., Head, G.A., Ricketts, J.H., 1996. Frequency and amplitude of sympathetic discharges by baroreflexes during hypoxia in conscious rabbits. Am. J. Physiol. 271, H2563-H2574.
13. Malpas, S.C., Ninomiya, I., 1992a. The amplitude and periodicity of synchronized renal sympathetic nerve discharges in anesthetized cats - differential effect of baroreceptor activity. J. Auton. Nerv. Syst. 40, 189-198.
14. Malpas, S.C., Ninomiya, I., 1992b. A new approach to analysis of synchronised sympathetic nerve activity. Am. J. Physiol. 263, H1311-H1317.
15. Nagahama, S., Chen, Y.F., Lindheimer, M.D., Oparil, S., 1986. Mechanism of the pressor action of LY171555, a specific dopamine D2 receptor agonist, in the conscious rat. J. Pharmacol. Exp. Ther. 236, 735-742.
16. Nagahama, S., Soo, A.M., Chen, Y.F., Lindheimer, M.D., Oparil, S., 1987. Role of vasopressin in the cardiovascular effects of LY171555, a selective dopamine D2 receptor agonist: studies in conscious Brattleboro and Long-Evans rats. J. Pharmacol. Exp. Ther. 242, 143-151.
17. Ninomiya, I., Akiyama, T., Nishiura, N., 1990. Mechanism of cardiac-related synchronized cardiac sympathetic activity in awake cats. Am. J. Physiol. 259, R499-R506.
18. Ninomiya, I., Malpas, S.C., Matsukawa, K., Shindo, T., Akiyama, T., 1993. The amplitude of synchronized cardiac sympathetic nerve activity reflects the number of activated pre- and postganglionic fibers in anesthetized cats. J. Auton. Nerv. Syst. 45, 139-147.
19. Sannajust, F., Head, G.A., 1994. Rilmenidine-induced hypotension in conscious rabbits involves imidazoline-preferring receptors. J. Cardiovasc. Pharmacol. 23, 42-50.
20. Sannajust, F., Barres, C., Koenig-Berard, E., Sassard, J., 1992. Sympathoinhibitory effects of rilmenidine may be mediated by sites located below the brainstem. Br. J. Pharmacol. 105, 535-541.
21. Van den Buuse, M., 1992. Central effects of quinpirole on blood pressure of spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 262, 303-311.
22. Van den Buuse, M., 1995. Differential effects of quinelorane and pergolide on behaviour, blood pressure, and body temperature of spontaneously hypertensive rats and Wistar-Kyoto rats. Pharmacol. Biochem. Behav. 50, 389-397.
23. Van den Buuse, M., 1997a. Pressor responses to brain dopaminergic stimulation. Clin. Exp. Pharmacol. Physiol. 24, 764-769.
24. Van den Buuse, M., 1997b. Pretreatment with quinpirole inhibits the central antihypertensive effects of rilmenidine and α-methyldopa in conscious rats. Eur. J. Pharmacol. 322, 191-199.
25. Van den Buuse, M., Tritton, S.B., 1997. Pretreatment with the dopamine agonist quinpirole inhibits central antihypertensive mechanisms in rats. Clin. Exp. Pharmacol. Physiol. 24, 661-666.
26. Van den Buuse, M., Morton, S.J., Cornish, J.L., Head, G.A., 1996. Prolonged effects of quinpirole on cardiovascular regulation. J. Pharmacol. Exp. Ther. 277, 473-483.
27. Wallenstein, S., Zucker, C.L., Fleiss, J.L., 1980. Some statistical methods useful in circulation research. Circ. Res. 47, 1-9.
28. Willems, J.L., Buylaert, W.A., Lefebvre, R.A., Bogaert, M.G., 1985. Neuronal dopamine receptors on autonomic ganglia and sympathetic nerves and dopamine receptors in the gastrointestinal system. Pharmacol. Rev. 37, 165-216.
29. Yang, R.H., Igarashi, Y., Wyss, J.M., Chen, Y.F., 1990. Dopamine D2 receptors in the posterior region of the nucleus tractus solitarius mediate the central pressor action of quinpirole (LY171555). Brain Res. Bull. 24, 97-103.