Secondary structure of the hepatitis C virus 5' untranslated region and efficacy of interferon therapy for chronic hepatitis C

Liver

Volumn 18, Issue 5, 1998, Pages 331-336

  Suzuki, Katsunori ^a   Shinzawa, Haruhide ^a   Kuboki, Makoto ^a   Ishibashi, Masamichi ^a   Yoshii, Eiichi ^a   Saito, Takafumi ^a   Takahashi, Tsuneo ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

5' untranslated region; Hepatitis C; Interferon; Internal ribosome entry site (IRES); Single strand confirmation polymorphisms

Indexed keywords

ALPHA INTERFERON; VIRUS RNA;

ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; DRUG EFFICACY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; MALE; POINT MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; RNA STRUCTURE; SEQUENCE ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0031783749     PISSN: 01069543     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0676.1998.tb00814.x     Document Type: Article

References (21)

1. HOOFNAGLE J H. Therapy of acute and chronic viral hepatitis. Adv Intern Med 1994, 39: 241-75.
2. SAITO T, SHINZAWA H, KUBOKI M, et al. A randomized, controlled trial of human lymphoblastoid interferon in patients with compensated type C cirrhosis. Am J Gastroenterol 1994; 89: 681-6.
3. HAGIWARA H, HAYASHI N, MITA E, et al. Quantitative analysis of hepatitis C virus RNA in serum during interferon alfa therapy. Gastroenterology 1993; 104: 877-83.
4. YOSHIOKA K, KAKUMU S, WAKITA T, et al. Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alpha therapy: relationship to genotypes of hepatitis C virus. Hepatology 1992; 16: 293-9.
5. KANAI K, KAKO M, OKAMOTO H. HCV genotypes in chronic hepatitis C and response to interferon. Lancet 1992; 339: 1543.
6. TSUBOTA A, CHAYAMA K, IKEDA K, et al. Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection. Hepatology 1994; 19: 1088-94.
7. GUEN B L, SQUADRITO G, NALPAS B, et al. Hepatitis C virus genome complexity correlates with response to interferon therapy: a study in French patients with chronic hepatitis C Hepatology 1997; 25: 1250-4.
8. KOIZUMI K, ENOMOTO N, KUROSAKI M, et al. Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment. Hepatology 1995; 22: 30-5.
9. ENOMOTO N, SAKUMA I, ASAHINA Y, et al. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b-sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 1995; 96: 224-30.
10. ENOMOTO N, SAKUMA I, ASAHINA Y, et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 1996; 334: 77-81.
11. MAJOR M E, FEINSTONE S M. The molecular virology of hepatitis C. Hepatology 1997; 25: 1527-38.
12. BROWN E A, ZHANG H, PING L-H, et al. Secondary structure of the 5′ nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res 1992; 20: 5041-5.
13. TSUKIYAMA-KOHARA K, IIZUKA N, KOHARA M, et al. Internal ribosome entry site within hepatitis C virus RNA. J Virol 1992; 66: 1476-83.
14. WANG C, SARNOW P, SIDDIQUI A. Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism. J Virol 1993; 67: 3338-44.
15. ORITA M, IWAHANA H, KANAZAWA H, et al. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci USA 1989; 86: 2766-70.
16. SIMMONDS P E, ALBERTI A, ALTER H J, et al. A proposed system for the nomenclature of hepatitis C viral genotypes. Hepatology 1994; 19: 1321-4.
17. WIDELL A, SHEV S, MANSSON S, et al. Genotyping of hepatitis C virus isolates by a modified polymerase chain reaction assay using type specific primers: epidemiological applications J Med Virol 1994; 44: 272-9.
18. YAMAMOTO C, ENOMOTO N, KUROSAKI M, et al. Nucleotide sequence variations in the internal ribosome entry site of hepatitis C virus-1b: no association with efficacy of interferon therapy or serum HCV-RNA levels. Hepatology 1997; 26: 1616-20.
19. KOLYKHALOV A A, AGAPOV E V, BLIGHT K J, et al. Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 1997; 277: 570-4.
20. YANAGI M, PURCELL R H, EMERSON SU, et al. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Proc Natl Acad Sci USA 1997; 94: 8738-43.
21. HONDA M, PING L H, RUNBRAND R C A, et al. Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA. Virology 1996; 222: 31-42.