Differential effects of pentoxifylline and interleukin-10 on production of tumor necrosis factor and inducible nitric oxide synthase by murine macrophages

Journal of Infectious Diseases

Volumn 175, Issue 4, 1997, Pages 1008-1111

  Loftis, Laura L ^b   Meals, Elizabeth A ^b   Keith English, B ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 10; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; DRUG EFFECT; GRAM NEGATIVE BACTERIUM; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK;

EID: 0030901344     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/513960     Document Type: Article

References (16)

1. Raetz C, Ulevitch R, Wright S, Sibley C, Ding A, Nathan C. Gramnegative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J 1993;5:2652-60.
2. Murray H. Interferon-gamma, the activated macrophage and the host defense against microbial challenge. Ann Intern Med 1988;108:595-608.
3. Tracey K. The acute and chronic pathophysiologic effects of TNF: mediation of septic shock and wasting (cachexia). In: Beutler B, ed. Tumor necrosis factors: the molecules and their emerging role in medicine. New York: Raven Press, 1992:255-73.
4. Szabo C. Alterations in nitric oxide production in various forms of circulatory shock. New Horizons 1995;3:2-32.
5. Nathan C, Xie Q. Nitric oxide synthases: roles, tolls, and controls. Cell 1994;78:915-8.
6. Anstey NM, Weinberg JB, Hassanali MY, et al. Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med 1996;184:557-67.
7. Nicholson S, Bonecini-Almeida MG, Silva JRL, et al. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis. J Exp Med 1996;183:2293-302.
8. Strieter R, Remick D, Ward P, et al. Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun 1988;155:1230-6.
9. Zeni F, Pain P, Vindimian M, et al. Effects of pentoxifylline on circulating cytokine concentrations and hemodynamics in patients with septic shock: results from a double-blind, randomized, placebo-controlled study. Crit Care Med 1996;24:207-14.
10. Nakayama I, Kawahara Y, Tsuda T, Koide M, Yokoyama M. Cyclic AMP elevating agents synergize with inflammatory cytokines to induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Ann NY Acad Sci 1995;748:586-9.
11. Lauterbach R, Grabowska A, Marcinkiewicz J. Effect of pentoxifylline on nitric oxide release by murine macrophages. Biol Neonate 1995;67: 72-6.
12. Moore K, O'Garra A, Malefyt R, Vieiraa P, Mosmann T. Interleukin-10. Annu Rev Immunol 1993;11:165-90.
13. Cunha F, Moncada S, Liew F. Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-gamma in murine macrophages. Biochem Biophys Res Commun 1992;182:1155-9.
14. Corradin SB, Fasel N, Buchmuller-Rouiller Y, Ransijn A, Smith J, Mauel J. Induction of macrophage nitric oxide production by interferon-gamma and tumor necrosis factor-alpha is enhanced by interleukin-10. Eur J Immunol 1993;23:2045-8.
15. Mattsson E, Van Dijk H, Van Kessel K, Verhoef J, Fleer A, Rollof J. Intracellular pathways involved in tumor necrosis factor-α release by human monocytes on stimulation with lipopolysaccharide or staphylococcal peptidoglycan are partly similar. J Infect Dis 1996;173:212-8.
16. Opal SM, Cross AS, Jhung JW, et al. Potential hazards of combination immunotherapy in the treatment of experimental septic shock. J Infect Dis 1996;173:1415-21.