The combination of interleukin-2 and interferon α effectively augments the antibody-dependent cellular cytotoxicity of monoclonal antibodies 17-1A and BR55-2 against the colorectal carcinoma cell line HT29

Cancer Immunology Immunotherapy

Volumn 46, Issue 4, 1998, Pages 213-220

  Bungard, Sven ^a   Flieger, Dimitri ^a   Schweitzer, Susann ^a   Sauerbruch, Tilman ^a   Spengler, Ulrich ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

ADCC; Colorectal carcinoma; Cytokine therapy; Flow cytometry; Monoclonal antibodies

Indexed keywords

ALPHA INTERFERON; COLONY STIMULATING FACTOR 1; EDRECOLOMAB; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY BR 55 2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY DETECTION; ARTICLE; CELL LEVEL; CELL STRAIN HT29; COLORECTAL CARCINOMA; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DRUG SYNERGISM; FLOW CYTOMETRY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HT29 CELLS; HUMANS; INTERFERON TYPE II; INTERFERON-ALPHA; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; MACROPHAGE COLONY-STIMULATING FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031777947     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050480     Document Type: Article

References (44)

1. Adams DO, Hall T, Steplewski Z, Koprowski H (1984) Tumors undergoing rejection induced by monoclonal antibodies of the IgG2a isotype contain increased numbers of macrophages activated for a distinctive form of antibody-dependent cytolysis. Proc Natl Acad Sci USA 81:3506
2. Aguet M, Vignaux F, Fridman WH, Gresser I (1981) Enhancement of Fc gamma receptor expression in interferon-treated mice. Eur J Immunol 11:926
3. Akiyama Y, Lubeck MD, Steplewski Z, Koprowski H (1984) Induction of mouse IgG2a-and IgG3-dependent cellular cytotoxicity in human monocytic cells (U937) by immune interferon. Cancer Res 44:5127
4. Blaszczyk-Thurin M, Thurin J, Hindsgaul O, Karlsson KA, Steplewski Z, Koprowski H (1987) Y and blood group B type 2 glycolipid antigens accumulate in a human gastric carcinoma cell line as detected by monoclonal antibody. Isolation and characterization by mass spectrometry and NMR spectroscopy. J Biol Chem 262:372
5. Blottiere HM, Douillard JY, Koprowski H, Steplewski Z (1990) Humoral and cellular responses of colorectal cancer patients treated with monoclonal antibodies and interferon γ. Cancer Immunol Immunother 3:29
6. Böyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at I g. Scand J Clin Lab Invest Suppl 97:77
7. Dingemans KP, Pels E, Dongen G van (1983) Destruction of murine lymphoma cells by allogeneic peritoneal macrophages in vitro: influence of antiserum. J Natl Cancer Inst 70:181
8. Eisenthal A, McIntosh JK (1990) Effect of recombinant human tumor necrosis factor alpha on the induction of antibody-dependent cellular cytotoxicity in the treatment of established B16 melanoma liver nodules. Cancer Immunol Immunother 31:243
9. Eisenthal A, Rosenberg SA (1989) The effect of various cytokines on the in vitro induction of antibody-dependent cellular cytotoxicity in murine cells. Enhancement of IL-2-induced antibody-dependent cellular cytotoxicity activity by IL-1 and tumor necrosis factor-alpha. J Immunol 142:2307
10. Flieger D, Gruber R, Schlimok G, Reiter C, Pantel K, Riethmüller G (1995) A novel non-radioactive cellular cytotoxicity test based on the differential assessment of living and killed target and effector cells. J Immunol Methods 180:1
11. Frödin J, Lefvert A, Mellstedt H (1990) Pharmacokinetics of the mouse monoclonal antibody 17-1A in cancer patients receiving various treatment schedules. Cancer Res 50:4866
12. Giacomini P, Tecce R, Gambari R, Sacchi A, Fisher PB, Natali PG (1988) Recombinant human IFN-gamma, but not IFN-alpha or IFN-beta, enhances MHC-and non-MHC-encoded glycoproteins by a protein synthesis-dependent mechanism. J Immunol 140:3073
13. Göttlinger HG, Funke I, Johnson JP, Gokel JM, Riethmüller G (1986) The epithelial cell surface antigen 17-1A, a target for antibody-mediated tumor therapy: its biochemical nature, tissue distribution and recognition by different monoclonal antibodies. Int J Cancer 38:47
14. Herberman RB, Ortaldo JR, Mantovani A, Hobbs DS, Kung HF, Pestka S (1982) Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes. Cell Immunol 67:160
15. Herlyn D, Koprowski H (1982) IgG2a monoclonal antibodies inhibit human tumor growth through interaction with effector cells. Proc Natl Acad Sci USA 79:4761
16. Herlyn M, Steplewski Z, Herlyn D, Koprowski H (1979) Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies. Proc Natl Acad Sci USA 70:1438
17. Johnson WJ, Bolognesi DP, Adams DO (1984) Antibody-dependent cytolysis (ADCC) of tumor cells by activated murine macrophages is a two-step process: quantification of target binding and subsequent target lysis. Cell Immunol 83:170
18. Johnson WJ, Steplewski Z, Matthews TJ, Hamilton TA, Koprowski H, Adams DO (1986) Cytolytic interactions between murine macrophages, tumor cells, and monoclonal antibodies: characterization of lytic conditions and requirements for effector activation. J Immunol 136:4704
19. Liesveld JL, Frediani KE, Winslow JM, Duerst RE, Abboud CN (1991) Cytokine effects and role of adhesive proteins and Fc receptors in human macrophage-mediated antibody dependent cellular cytotoxicity. J Cell Biochem 45:381
20. Lubeck MD, Steplewski Z, Baglia F, Klein MH, Dorrington KJ, Koprowski H (1985) The interaction of murine IgG subclass proteins with human monocyte Fc receptors. J Immunol 135:1299
21. Lubeck MD, Kimoto Y, Steplewski Z, Koprowski H (1988) Killing of human tumor cell lines by human monocytes and murine monoclonal antibodies. Cell Immunol 111:107
22. Malkovsky M, Loveland B, North M, Asherson GL, Gao L, Ward P, Fiers W (1987) Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes. Nature 325:262
23. Masucci G, Wersäll P, Ragnhammar P, Mellstedt H (1989) Granulocyte-monocyte-colony-stimulating factor augments the cytotoxic capacity of lymphocytes and monocytes in antibody-dependent cellular cytotoxicity. Cancer Immunol Immunother 29:288
24. Masucci G, Wersäll P, Nielsen J, Nielsen HK, Wigzell H, Mellstedt H (1989) Lymphokine activated killer (LAK) cells in antibody dependent cellular cytotoxicity (ADCC) using mAb 17-1A: a combination of potential usefulness in tumor therapy. Hybridoma 8:507
25. Masucci G, Ragnhammar P, Wersäll P, Mellstedt H (1990) Granulocyte-monocyte colony-stimulating-factor augments the interleukin-2-induced cytotoxic activity of human lymphocytes in the absence and presence of mouse or chimeric monoclonal antibodies (mAb 17-1A). Cancer Immunol Immunother 31:231
26. Mufson RA, Aghajanian J, Wong G, Woodhouse C, Morgan AC (1989) Macrophage colony-stimulating factor enhances monocyte and macrophage antibody-dependent cell-mediated cytotoxicity. Cell Immunol 119:182
27. Munn DH, Cheung NK (1987) Interleukin-2 enhancement of monoclonal antibody-mediated cellular cytotoxicity against human melanoma. Cancer Res 47:6600
28. Munn DH, Cheung NK (1989) Antibody-dependent antitumor cytotoxicity by human monocytes cultured with recombinant macrophage colony-stimulating factor. Induction of efficient antibody-mediated antitumor cytotoxicity not detected by isotope release assays. J Exp Med 170:511
29. Munn DH, Cheung NK (1995) Antibody-independent phagocytosis of tumor cells by human monocyte-derived macrophages cultured in recombinant macrophage colony-stimulating factor. Cancer Immunol Immunother 41:46
30. Okabe M, Gomi K, Morimoto M, Nakamizo N (1985) The different effects of recombinant human interferon-gamma and recombinant human interferon-beta on the activation of natural killer cells. Jpn J Cancer Res 76:608
31. Ortaldo JR, Woodhouse C, Morgan AC, Herberman RB, Cheresh DA, Reisfeld R (1987) Analysis of effector cells in human antibody-dependent cellular cytotoxicity with murine monoclonal antibodies. J Immunol 138:3566
32. Ragnhammar P, Frödin J, Trotta P, Mellstedt H (1994) Cytotoxicity of white blood cells activated by granulocyte-colony-stimulating factor, granulocyte/macrophage-colony-stimulating factor and macrophage-colony-stimulating factor against tumor cells in the presence of various monoclonal antibodies. Cancer Immunol Immunother 39:254
33. Ralph P, Nakoinz I, Rennick D (1988) Role of interleukin 2, interleukin 4, and α, β, and γ interferon in stimulating macrophage antibody-dependent tumoricidal activity. J Exp Med 167:712
34. Riethmüller G, Schneider-Gädicke E, Schlimok G, Schmiegel W, Raab R, Höffken K, Gruber R, Pichlmaier H, Hirche H, Pichlmayr R, Buggisch P, Witte J, the German Cancer Aid 17-1A Study Group (1994) Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma Lancet 343:1177
35. Sanda MG, Bolton E, Mule JJ, Rosenberg SA (1992) In vivo administration of recombinant macrophage colony-stimulating factor induces macrophage-mediated antibody-dependent cytotoxicity of tumor cells. J Immunother 12:132
36. Scholz D, Lubeck M, Loibner H, McDonald-Smith J, Kimoto Y, Koprowski H, Steplewski Z (1991) Biological activity in the human system of isotype variants of oligosaccharide-Y-specific murine monoclonal antibodies. Cancer Immunol Immunother 33:153
37. Shetye J, Christensson B, Rubio C, Rodensjö M, Biberfeld P, Mellstedt H (1989) The tumor-associated antigens BR55-2, GA73-3 and GICA 19-9 in normal and corresponding neoplastic human tissues, especially gastrointestinal tissues. Anticancer 9:395
38. Staib L, Link KH, Büchler M (1991) Steigerung der Zytotoxizität spezifischer monoklonaler Antikörper gegen humane Karzinomzellen durch GM-CSF in vitro. Onkologie 14:261
39. Steplewski Z, Lubeck MD, Koprowski H (1983) Human macrophages armed with murine immunoglobulin G2a antibodies to tumors destroy human cancer cells. Science 221:865
40. Steplewski Z, Lubeck MD, Scholz D, Loibner H, McDonald Smith J, Koprowski H (1991) Tumor cell lysis and tumor growth inhibition by the isotype variants of mAb BR55-2 directed against Y oligosaccharide. In Vivo 5:79
41. Takamuku K, Baba K, Arinaga S, Li J, Mori M, Akiyoshi T (1996) Apoptosis in antibody-dependent monocyte-mediated cytotoxicity with monoclonal antibody 17-1A against human colorectal carcinoma cells: enhancement with interferon gamma. Cancer Immunol Immunother 43:220
42. Tweardy DJ, Fujiwara H, Scillian JJ, Ellner JJ (1986) Concurrent enhancement of monocyte immunoregulatory properties and effector functions by recombinant interferon-gamma. Cell Immunol 100:34
43. Vuist WM, Visseren MJ, Otsen M, Bos K, Vyth-Dreese FA, Figdor CG, Melief CJ, Hekman A (1993) Enhancement of the antibody-dependent cellular cytotoxicity of human peripheral blood lymphocytes with interleukin-2 and interferon alpha. Cancer Immunol Immunother 36:163
44. Weiner LM, Steplewski Z, Koprowski H, Sears HE, Litwin S, Comis RL (1986) Biologic effects of gamma interferon pretreatment followed by monoclonal antibody 17-1A administration in patients with gastrointestinal carcinoma. Hybridoma 5 Suppl 1:S65