Quantitative evaluation of leukocyte infiltration into the spinal cord in a model of experimental autoimmune encephalomyelitis: Statistical-analytical techniques for use in evaluating drugs

International Journal of Immunopathology and Pharmacology

Volumn 11, Issue 3, 1998, Pages 117-137

  Chapman, D L ^a   Vroegop, S M ^a   Galinet, L A ^a   Ready, K A ^a   Dunn, C J ^a   Vidmar, T J ^a   Buxser, S E ^a  

^a PFIZER INC   (United States)

Author keywords

EAE; Experimental autoimmune encephalomyelitis; Immunocytochemnistry; Leukocyte infiltration; Negative binomial distribution

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CELL SURFACE MARKER; MONOCLONAL ANTIBODY;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECURRENT DISEASE; STATISTICAL ANALYSIS;

EID: 0031774130     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463209801100302     Document Type: Article

References (50)

1. Raine C.S., L.B. Barnett, A. Brown, T. Behar and D.E. McFarlin. 1980. Neuropathology of experimental allergic encephalomyelitis in inbred strains of mice. Lab. Invest. 43:150.
2. Lando Z., D. Teitelbaum and R. Arnon. 1980. Induction of experimental allergic encephalomyelitis in genetically resistant strains of mice. Nature 287:551.
3. Swanborg R.H. 1995. Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. Clin. Immunol. Immunopath. 77:4.
4. Raine C.S. 1991. Multiple Sclerosis; a pivotal role for the T cell in lesion development. Neuropathol. Appl. Neurobiol. 17:265.
5. Dijkstra C.D., C.H. Polman and F. Berkenbosch. 1993. Multiple sclerosis: some possible therapeutic opportunities. Trends Pharmacol. 14:124.
6. Moor A.C.E., H.E. De Vries, A.G. De Boer and D.D. Breimer. 1994. The blood-brain barrier and multiple sclerosis. Biochem. Pharm. 47:1717.
7. Fabry Z., C.S. Raine and M.N Hart. 1994. Nervous tissue as an immune compartment: the dialect of the immune response in the CNS. Immunol. Today 15:218.
8. Martin R., H.F. McFarland and D.E. McFarlin. 1992. Immunological aspects of demyelinating diseases. Annu. Rev. Immunol. 10:153.
9. Rivers T.M., D.H. Sprunt and G.P. Berry. 1933. Observations on attempts to produce disseminated encephalomyelitis in monkeys. J. Exp. Med. 58:39.
10. Kabat E.A., A. Wolfe and A.E. Bezer. 1946. The rapid production of acute disseminated encephalomyelitis in rhesus monkeys by injection of brain tissue with adjuvants. Science 104:362.
11. Martenson R.E. 1984. Myelin basic protein speciation. In Experimental Allergic Encephalomyelitis: A Useful Model for Multiple Sclerosis. E.G. Alford, Jr., ed. Liss, New York, p. 146.
12. Paterson P.Y. 1960. Transfer of allergic encephalomyelitis in rats by means of lymph node cells. J. Exp. Med. 111:119.
13. Ben-Nun A., H. Wekerle and I.R. Cohen. 1981. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol. 11:195.
14. Pettinelli C.B and D.E. MacFarlin. 1981. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vivo activation of lymph node cells by myelin basic protein: requirement for Lyt1+2- T lymphocytes. J. Immunol. 127:1420.
15. Traugott U., D.E. McFarlin and C.S. Raine. 1986. Immunopathology of the lesion in chronic relapsing experimental autoimmune encephalomyelitis in the mouse. Cell. Immunol. 99:395.
16. Raine C.S., B. Cannella, A.M. Duijvestijn and A.H. Cross. 1990. Homing to central nervous system vasculature by antigen-specific lymphocytes II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Lab. Invest. 63:476.
17. Merrill J.E., D.H. Kono, J. Clayton, D.G. Ando, D.R. Hinton and F.M. Hofman. 1992. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice. Proc. Natl. Acad. Sci. 89:574.
18. Hickey W.F. and N.K. Gonatas. 1984. Suppressor T-lymphocytes in the spinal cords of Lewis rats recovered from acute experimental allergic encephalomyelitis. Cell. Immunol. 85:284.
19. Hickey W.F., N.K. Gonatas, H. Kimura and D.B. Wilson. 1983. Identification and quantitation of T lymphocyte subsets found in the spinal cord of the Lewis rat during acute experimental allergic encephalomyelitis. J. Immunol. 131:2805.
20. Sobel R.A., B.W. Blanchette, A.K. Bhan and R.B.Colvin. 1984. The immunopathology or experimental allergic encephalomyelitis. I. Quantitative analysis of inflammatory cells in situ. J. Immunol. 132:2393.
21. Sedgwick J., S. Brostoff and D. Mason. 1987. Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. J. Exp. Med. 165:1058.
22. Baron J.L., J.A. Madri, N.H. Ruddle, G. Hashim and C.A. Janeway. 1993. Surface expression of alpha-4 integrin by CD4 T cells is required for the entry into brain parenchyma. J. Exp. Med. 177:57.
23. Kent S.J., S.J. Karlaick, C. Cannon, D.K. Hines, T.A. Yadnock, L.C. Frtiz and H.C. Horner. 1995. A monoclonal antibody to 4-integrin suppresses and reverses active experiemental allergic encephalomyelitis. J. Neuroimmunol. 58:1.
24. Prophet, E.B., B. Mills, J.B. Arrington, and L.H. Sobin. 1992. Manual of Histological Staining Methods of the Armed Forces Institute of Pathology. 3rd ed., McGraw-Hill, New York.
25. Mantel N. and W. Haenszel. 1959. Statistical aspects of the analysis of data from retrospective studies of disease. J. Nat. Can. Inst. 22:719.
26. Zar J.H. 1984. In (a) Biostatistical Analysis. Prentice Hall, Englewood Heights, NJ, p. 176. (b) ibid. p. 390. ibid. p. 406.
27. Zar J.H. 1984. In (a) Biostatistical Analysis. Prentice Hall, Englewood Heights, NJ, p. 176. (b) ibid. p. 390. ibid. p. 406.
28. Zar J.H. 1984. In (a) Biostatistical Analysis. Prentice Hall, Englewood Heights, NJ, p. 176. (b) ibid. p. 390. ibid. p. 406.
29. Hollander M. and D. Wolfe. 1973. In: Nonparametric Statistical Methods. John Wiley and Sons, New York.
30. Bliss C.I. and R.A. Fisher. 1953. Fitting the negative binomial distribution to biological data. Biometrics 9:176.
31. Montmort P.R. In Essai d'analyse sur les jeux de hasards, Paris. P. 1714.
32. Fisher R.A., A.S. Corbett and C.B. Williams. 1943. The relation between the number of species and the number of individuals in a random sample of an animal population. J. Animal Ecology 12:42.
33. Fisher R.A. 1942. The negative binomial distribution. Ann. Eugenics 11:182.
34. Press W.H., B.P. Flannery, S.A. Teukolsky and W.T. Vetterling. 1986. In Numerical Recipes. Cambridge University Press, Cambridge, p. 254.
35. SAS Institute Inc. 1989. In SAS/STAT User's Guide. Version 6, Fourth ed., SAS Institute Inc., Cary, NC.
36. Waters W.E. and W.R. Henson. 1959. Some sampling attributes of the negative binomial distribution with special reference to forest insects. Forest Science 5:397.
37. DeGroot M.H. 1975. In Probability and Statistics. Addison-Wesley Publishing Co., Reading, MA, p. 209.
38. Snedecor G.W. and W.G. Cochran. 1980. In Statistical Methods. Seventh ed. Ames: The Iowa State University Press, p. 282.
39. McMahon R.P., M. Proschan, N.L. Geller, P.H. Stone and G. Sopko. 1994. Sample size calculation for clinical trials in which entry criteria and outcomes are counts of events. Statistics in Medicine 13:859.
40. Bauer J., I. Huitinga, W. Zhao, H. Lassmann, W.F. Hickey and C.D. Dijkstra. 1995. The role of macrophages, perivascular cells, and microglia cells in the pathogenesis of experimental autoimmune encephalomyelitis. Glia 15:437.
41. Traugott U., C.S. Raine and D.E. McFarlin. 1985. Acute experimental allergic encephalomyelitis in the mouse: Immunopathology of the developing lesion. Cell. Immunol. 91:240.
42. Racke M.K., L. Quigley, B. Cannella, C.S. Raine, D.E. MacFarlin and D.E. Scott. 1994. Superantigen modulation of experimental allergic encephalomyelitis. J. Immunol. 152:2051.
43. Robbinson D., S. Conkle, B. Singh and G.H. Strejan. 1996. Native, but genetically inactivated, pertussis toxin protects mice against experimental allergic encephalomyelitis. Cell. Immunol. 168:165.
44. Yu M., A. Nishiyama, B.D. Trapp and V.K. Tuohy. 1996. Interferon-β inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis. J. Neuroimmunol. 64:91.
45. Wekerle H. 1993. Lymphocytes traffic to the brain.In The Blood-Brain Barrier. W.M. Pardridge, ed. Raven Press, New York, p. 67.
46. Eng L.F., R.S. Ghirnikar and Y.L. Lee. 1996. Inflammation in EAE: role of chemokine/cytokine expression by resident and infiltrating cells. Neurochemical Res. 21:511.
47. Huitinga I., S.R. Ruuls, S. Jung, N. Van Rooijen, H.P. Hartung and C.D. Dijkstra. 1995. Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats. Clin. Exp. Immunol. 100:344.
48. Perry V.H., M.C. Brown and P. Andersson. 1993. Manipulating macrophages in nervous system repair. In Neuronal Cell Death and Repair. A.C. Cuello, ed. Elsevier Science Publishers B.V., p. 193.
49. Leeson C.R. and T.S. Leeson. 1976. In Histology. 3rd ed. W.B. Saunders Co., Philadelphia, London, Toronto.
50. David and Moore. 1954. Notes on contagious distributions in plant populations. Ann. Bot. Lond. N.S. 18:47.