Potentiating action of MKC-242, a selective 5-HT(1A) receptor agonist, on the photic entrainment of the circadian activity rhythm in hamsters

British Journal of Pharmacology

Volumn 125, Issue 6, 1998, Pages 1281-1287

  Moriya, T ^a   Yoshinobu, Y ^a   Ikeda, M ^a   Yokota, S ^a   Akiyama, M ^a   Shibata, S ^a  

^a WASEDA UNIVERSITY   (Japan)

Author keywords

5 HT(1A) receptor; 5 Hydroxytryptamine (5 HT); Circadian rhythm; Light entrainment

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 5 HYDROXYINDOLEACETIC ACID; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; OSEMOZOTAN; RECEPTOR SUBTYPE; RITANSERIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL RHYTHM; CIRCADIAN RHYTHM; CONTROLLED STUDY; GENE EXPRESSION; HAMSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; LIGHT EXPOSURE; MALE; MESENCEPHALON; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAPHE NUCLEUS; SUPRACHIASMATIC NUCLEUS;

EID: 0031773912     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702176     Document Type: Article

References (34)

1. ABE, M., TABATA, R., SAITO, K., MATSUDA, T., BABA, A. & EGAWA, M. (1996). Novel benzodioxan derivative, 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole HCl (MKC-242), with anxiolytic-like and antidepressant-like effects in animal models. J. Pharmacol. Exp. Ther., 278, 898-905.
2. ASANO, S., MATSUDA, T., YOSHIKAWA, T., SOMBOONTHUM, P., TASAKI, H., ABE, M. & BABA, A. (1997). Interaction of orally administered 5-3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy-1,3-benzodioxole (MKC-242) with 5-HT1A receptors in rat brain. Jpn. J. Pharmacol., 74, 69-75.
3. BIELLO, S.M. & MROSOVSKY, N. (1995). Blocking the phase-shifting effect of neuropeptide Y with light. Proc. R. Soc. Lond. B. Biol. Sci., 259, 179-187.
4. BOULOS, Z. (1995). Wavelength dependence of light-induced phase shifts and period changes in hamsters. Physiol. Behav., 57, 1025-1033.
5. BRADBURY, M.J., DEMENT, W.C. & EDGAR, D.M. (1997). Serotonin-containing fibers in the suprachiasmatic hypothalamus attenuate light-induced phase delays in mice. Brain Res., 768, 125-134.
6. CAGAMPANG, F.R. & INOUYE, S.T. (1994). Diurnal and circadian changes of serotonin in the suprachiasmatic nuclei: regulation by light and an endogenous pacemaker. Brain Res., 639, 175-179.
7. CAGAMPANG, F.R., YAMAZAKI, S, OTORI, Y. & INOUYE, S.I. (1993). Serotonin in the raphe nuclei: regulation by light and an endogenous pacemaker. Neuroreport, 5, 49-52.
8. GLASS, J.D., SELIM, M. & REA, M.A. (1994). Modulation of light-induced C-Fos expression in the suprachiasmatic nuclei by 5-HT1A receptor agonists. Brain Res., 638, 235-242.
9. GLASS, J.D., SELIM, M., SRKALOVIC, G. & REA, M.A. (1995). Tryptophan loading modulates light-induced responses in the mammalian circadian system. J. Biol. Rhythms., 10, 80-90.
10. INOUYE, S.T. & SHIBATA, S. (1994). Neurochemical organization of circadian rhythm in the suprachiasmatic nucleus. Neurosci. Res., 20, 109-130.
11. LIOU, S.Y., SHIBATA, S. & UEKI, S. (1986). Effect of monoamines on field potentials in the suprachiasmatic nuclei of slices of hypothalmus of the rat evoked by stimulation of the optic nerve Neuropharmacology, 25, 1009-1014.
12. LOVENBERG, T.W., BARON, B.M., DE LECEA, L., MILLER, J.D., PROSSER, R.A., REA, M.A., FOYE, P.E., RACKE, M., SLONE, A.L., SIEGEL, B.W., DANIELSON, P.E., SUTCLIFFE, J.E. & ERLANDER, M.G. (1993). A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron, 11, 449-458.
13. MATSUDA, T., SOMBOONTHUM, P., SUZUKI, M., ASANO, S. & BABA, A. (1995a). Antidepressant-like effect by postsynaptic 5-HT1A receptor activation in mice. Eur. J. Pharmacol., 280, 235-238.
14. MATSUDA, T., YOSHIKAWA, T., SUZUKI, M., ASANO, S., SOMBOONTHUM, P, TAKUMA, K., NAKANO, Y., MORITA, T., NAKASU, Y., KIM, H.S., EGAWA, M., TOBE, A. & BABA, A. (1995b). Novel benzodioxan derivative, 5-(3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy)-1,3-benzodioxole HCl (MKC-242), with a highly potent and selective agonist activity at rat central serotonin 1A receptors. Jpn. J. Pharmacol., 69, 357-366.
15. MEYER-BERNSTEIN, E.L. & MORIN, L.P. (1996). Differential serotonergic innervation of the suprachiasmatic nuclei and the intergeniculate leaflet and its role in circadian rhythm modula-tion. J. Neurosci., 16, 2097-2111.
16. MINTZ, E.M., GILLESPIE, C.F., MARVEL, C.L., HUHMAN, K.L. & ALBERS, H.E. (1997). Serotonergic regulation of circadian rhythms in Syrian hamsters. Neuroscience, 79, 563-569.
17. MORIN, L.P. & BLANCHARD, J. (1991). Depletion of brain serotonin by 5,7-DHT modifies hamster circadian rhythm response to light. Brain Res., 566, 173-185.
18. MORIYA, T., YAMANOUCHI, S., FUKUSHIMA, T., SHIMAZOE, T., SHIBATA, S. & WATANABE, S. (1996). Involvement of 5-HT1A receptor mechanisms in the inhibitory effects of methamphetamine on photic responses in the rodent suprachiasmatic nuclei. Brain Res., 740, 261-267.
19. ONO, M., WATANABE, A., MATSUMOTO, Y., FUKUSHIMA, T., NISHIKAWA, Y., MORIYA, T., SHIBATA, S. & WATANABE, S. (1996). Methamphetamine modifies the photic entraining responses in the rodent suprachiasmatic nuclei via serotonin release. Neuroscience, 72, 213-224.
20. PENEV, P.D., TUREK, F.W. & ZEE, P.C. (1993). Monoamine depletion alters the entrainment and the response to light of the circadian activity rhythm in hamsters. Brain Res., 612, 156-164.
21. PICKARD, G.E. & REA, M.A. (1997). TFMPP, a 5HT1B receptor agonist, inhibits light-induced phase shifts of the circadian activity rhythm and c-Fos expression in the mouse suprachiasmatic nuclei. Neurosci. Lett., 231, 95-98.
22. PICKARD, G.E., WEBER, E.T., SCOTT, P.A., RIBERDY, A.F. & REA, M.A. (1996). 5HT1B receptor agonists inhibit light-induced phase shifts of behavioral circadian rhythms and expression of the immediate-early gene c-fos in the suprachiasmatic nuclei. J. Neurosci., 16, 8208-8220.
23. REA, M.A., BARRERA, J, GLASS, J.D. & GANNON, R.L. (1995). Serotonergic potentiation of photic phase shifts of the circadian activity rhythm. Neuroreport, 6, 1417-1420.
24. REA, M.A., GLASS, J.D. & COLWELL, C.S. (1994). Serotonin modulates photic responses in the hamster suprachiasmatic nuclei. J. Neurosci., 14, 3635-3642.
25. ROCA, A.L., WEAVER, D.R. & REPPERT, S.M. (1993). Serotonin receptor gene expression in the rat suprachiasmatic nuclei. Brain Res., 608, 159-165.
26. SELIM, M., GLASS, J.D., HAUSER, U.E. & REA, M.A. (1993). Serotonergic inhibition of light-induced fos protein expression and extracellular glutamate in the suprachiasmatic nuclei. Brain Res., 621, 181-188.
27. SRKALOVlC, G., SELIM, M., REA, M.A. & GLASS, J.D. (1994). Serotonergic inhibition of extracellular glutamate in the suprachismatic nuclear region assessed using in vivo brain microdialysis. Brain Res., 656, 302-308.
28. SUZUKI, M., MATSUDA, T., ASANO, S., SOMBOONTHUM, P., TAKUMA, K. & BABA, A. (1995). Increase of noradrenaline release in the hypothalamus of freely moving rat by postsynaptic 5-hydroxytryptamine1A receptor activation. Br. J. Pharmacol., 115, 703-711.
29. WEBER, E.T., GANNON, R.L., MICHEL, A.M., GILLETTE, M.U. & REA, M.A. (1995). Nitric oxide synthase inhibitor blocks lightinduced phase shifts of the circadian activity rhythm, but not c-fos expression in the suprachiasmatic nuclei of the Syrian hamster. Brain Res., 692, 137-142.
30. WEBER, E.T., MICHEL, A.M., GANNON, R.L., CATO, M.L. & REA, M.A. (1996). Local serotonin agonists dose-dependently attenuate light-induced phase advances of the suprachiasmatic nuclei in vivo. Soc. Neurosci. Abstr., 22, 1141.
31. WRIGHT, D.E., SEROOGY, K.B., LUNDGREN, K.H., DAVIS, B.M. & JENNES, L. (1995). Comparative localization of serotonin 1A, 1C, and 2 receptor subtype mRNAs in rat brain. J. Comp. Neurol., 351, 357-373.
32. YING, S.W. & RUSAK, B. (1994). Effects of serotonergic agonists on firing rates of photically responsive cells in the hamster suprachiasmatic nuclei. Brain Res., 651, 37-46.
33. YING, S.W. & RUSAK, B. (1997). 5-HT7 receptors mediate serotonergic effects on light-sensitive suprachiasmatic nuclei neurons. Brain Res., 755, 246-254.
34. YING, S.W., ZHANG, D.X. & RUSAK, B. (1993). Effects of serotonin agonists and melatonin on photic responses of hamster intergeniculate leaflet neurons. Brain Res., 628, 8-16.