Interaction of orally administered 5-{3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy}-1,3-benzodioxole (MKC-242) with 5-HT(1A) receptors in rat brain

Japanese Journal of Pharmacology

Volumn 74, Issue 1, 1997, Pages 69-75

  Asano, Shoichi ^a   Matsuda, Toshio ^a   Yoshikawa, Takashi ^a   Somboonthum, Pranee ^a   Tasaki, Hatsue ^a   Abe, Michikazu ^b   Baba, Akemichi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

5 HT(1A) receptor agonist; 5 3 ((2S) 1,4 benzodioxan 2 ylmethyl)amino propoxy 1,3 benzodioxole (MKC 242); Anxiolytic; Autoradiography

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; BRAIN RECEPTOR; BUSPIRONE; OSEMOZOTAN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN INJURY; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG RECEPTOR BINDING; HIPPOCAMPUS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RADIORECEPTOR ASSAY; RAT; RECEPTOR DENSITY;

EID: 0030918219     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.74.69     Document Type: Article

References (29)

1. Taylor DP: Serotonin agents in anxiety. Ann NY Acad Sci 600, 545-556 (1990)
2. Shimizu H, Kumasaka Y, Tanaka H, Hirose A and Nakamura M: Anticonflict action of tandospirone in a modified Geller-Seifter conflict test in rats. Jpn J Pharmacol 58, 283-289 (1992)
3. Lucki I, Singh A and Kreiss DS: Antidepressant-like behavioral effects of serotonin receptor agonists. Neurosci Biobehav Rev 18, 85-95 (1994)
4. 1A agonists with potential anxiolytic properties. J Pharmacol Exp Ther 246, 745-752 (1988)
5. 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP). Eur J Pharmacol 151, 365-371 (1988)
6. 2-adrenoceptors in the rat brain. Eur J Pharmacol 180, 183-186 (1990)
7. 1A receptor agonist, ipsapirone, does not affect 8-OH-DPAT-and stress-induced increases in plasma adrenaline levels in the rat. Eur J Pharmacol 198, 129-135 (1991)
8. Evenden JL: Effects of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) after repeated administration on a conditioned avoidance response (CAR) in the rat. Psychopharmacology (Berlin) 109, 134-144 (1992)
9. Wieland S, Fischette CT and Lucki 1: Effect of chronic treatments with tandospirone and imipramine on serotonin-mediated behavioral responses and monoamine receptors. Neuropharmacology 32, 561-573 (1993)
10. 1A autoreceptor desensitization following chronic citalopram treatment, as determined by in vivo microdialysis. Neuropharmacology 33, 331-334 (1994)
11. 1A receptors. Jpn J Pharmacol 69, 357-366 (1995)
12. Abe M, Tabata R, Saito K, Matsuda T, Baba A and Egawa M: Novel benzodioxan derivative, 5-{3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino] propoxyl}-1,3-benzodioxole HCl (HCl), with anxiolytic-like and antidepressant-like effects in animal models. J Pharmacol Exp Ther 278, 898-905 (1996)
13. 1A binding in rat brain - a combined in situ hybridisation/in vitro receptor autoradiographic study. Brain Res 561, 51-60 (1991)
14. Paxinos G and Watson C: The Rat Brain in Stereotaxic Coordinates, Second Edition. Academic Press, San Diego (1986)
15. 1A receptor activation. Br J Pharmacol 115, 703-711 (1995)
16. Matsuda T, Somboonthum P, Suzuki M, Asano S and Baba A: Antidepressant-like effect by postsynaptic 5-HT1A receptor activation in mice. Eur J Pharmacol 280, 235-238 (1995)
17. 1A receptor antagonists. Psychopharmacology (Berlin) 119, 47-54 (1995)
18. 3H]WAY 100635 in the mouse. Eur J Pharmacol 271, 505-514 (1994)
19. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J Neurosci 6, 3474-3482 (1986)
20. 1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology 4, 131-144 (1991)
21. 1A receptors. Eur J Pharmacol 170, 75-82 (1989)
22. 1A receptor agonists. Eur J Pharmacol 200, 299-304 (1991)
23. 1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone. J Pharmacol Exp Ther 265, 7-15 (1993)
24. 1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins. J Pharmacol Exp Ther 265, 16-23 (1993)
25. 1A receptors and pharmacotherapy. Is serotonin receptor down-regulation linked to the mechanism of action of antidepressant drugs? Psychopharmacol Bull 30, 39-43 (1994)
26. 1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn Schmiedebergs Arch Pharmacol 352, 141-148 (1995)
27. Kreiss DS and Lucki I: Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo. J Pharmacol Exp Ther 274, 866-876 (1995)
28. 1A receptors in rat brain following antidepressant drug treatment. Synapse 4, 347-352 (1989)
29. 1A agonist. J Pharmcol Exp Ther 279, 1035-1042 (1996)