Pathogenesis of atherosclerosis: The alternative hypothesis

Journal of Interventional Cardiology

Volumn 11, Issue 6, 1998, Pages 529-534

  Bhakdi, Sucharit ^a,b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Inst of Med Microbiol and Hygiene   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN;

ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; COMPLEMENT ACTIVATION; ENZYME DEGRADATION; ENZYME MODIFICATION; EXTRACELLULAR MATRIX; FOAM CELL; HUMAN; HYPOTHESIS; MACROPHAGE ACTIVATION; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0031772425     PISSN: 08964327     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8183.1998.tb00164.x     Document Type: Article

References (29)

1. Goldstein JL, Brown MS. The low-density lipoprotein pathway and its relation to atherosclerosis. Annu Rev Biochem 1977;46:897-930.
2. Goldstein JL, Ho YK, Basu SK, Brown MS. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci USA 1979;76:333-337.
3. Brown MS, Goldstein JL. Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem 1983;52:223-261.
4. Steinbrecher UP, Parthasarathy S, Carew TE, et al. Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids. Proc Natl Acad Sci USA 1984;81:3883-3887.
5. Steinberg D. Oxidative modification of LDL and atherogenesis. Circulation 1997;94:1062-1071.
6. Steinbrecher UP, Lougheed M. Scavenger receptor-independent stimulation of cholesterol esterification in macrophages by low density lipoprotein extracted from human aortic intima. Arterioscler Thromb 1992;12:608-625.
7. Kühn H, Heydeck D, Hugou I, et al. In vivo action of 15-lipoxygenase in early stages of human atherogenesis. J Clin Invest 1997;99:888-893.
8. Haberland ME, Fong D, Cheng L. Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits. Science 1988;241:215-218.
9. Ylä-Herttuala S, Palinski W, Rosenfeld ME, et al. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 1989;84:1086-1095.
10. Palinski W, Ylä-Herttuala S, Rosenfeld ME, et al. Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein. Arteriosclerosis 1990;10:325-335.
11. Hammer A, Kager G, Dohr G, et al. Generation, characterization, and histochemical application of monoclonal antibodies selectively recognizing oxidatively modified apoB-containing serum lipoproteins. Arterioscler Thromb Vasc Biol 1995; 15:704-713.
12. Napoli C, D'Armiento FP, Mancini FP, et al. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. J Clin Invest 1997;100: 2680-2690.
13. Jürgens G, Chen Q, Esterbauer H, et al. Immunostaining of human autopsy aortas with antibodies to modified apolipoprotein B and apoprotein (a). Arterioscler Thromb 1993;13:1689-1699.
14. Frank JS, Fogelman AM. Ultrastructure of the intima in WHHL and cholesterol-fed rabbit aortas prepared by ultra-rapid freezing and freeze-etching. J Lipid Res 1989;30: 967-978.
15. Simionescu N, Vasile E, Lupu F, et al. Prelesional events in atherogenesis. Accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit. Am J Pathol 1986;123:109-125.
16. Mora R, Lupu F, Simionescu N. Prelesional events in atherogenesis. Colocalization of apolipoprotein B, unesterified cholesterol and extracellular phospholipid liposomes in the aorta of hyperlipidemic rabbit. Atherosclerosis 1987;67: 143-154.
17. Chao FF, Amende LM, Blanchette Mackie EJ, et al. Unesterified cholesterol-rich lipid particles in atherosclerotic lesions of human and rabbit aortas. Am J Pathol 1988;131:73-83.
18. Vlaicu R, Niculescu F, Rus HG, et al. Immunohistochemical localization of the terminal C5b-9 complement complex in human aortic fibrous plaque. Atherosclerosis 1985;57:163-167.
19. Niculescu F, Hugo F, Rus HG, et al. Quantitative evaluation of the terminal C5b-9 complement complex by ELISA in human atherosclerotic arteries. Clin Exp Immunol 1987;69:477-483.
20. Seifert PS, Hugo F, Hansson GK, et al. Prelesional complement activation in experimental atherosclerosis. Terminal C5b-9 complement deposition coincides with cholesterol accumulation in the aortic intima of hypercholesterolemic rabbits. Lab Invest 1989;60:747-754.
21. Seifert PS, Hugo F, Tranum-Jensen J, et al. Isolation and characterization of a complement-activating lipid extracted from human atherosclerotic lesions. J Exp Med 1990;172:547-557.
22. Alving CR, Richards RL, Guirguis AH. Cholesterol-dependent human complement activation resulting in damage to liposomal model membranes. J Immunol 1977;188:342-347.
23. Bhakdi S, Dorweiler B, Kirchmann R, et al. On the pathogenesis of atherosclerosis: Enzymatic transformation of human low density lipoprotein to an atherogenic moiety. J Exp Med 1995;182:1959-1971.
24. Klouche M, Gottschling S, Gerl V, et al. Atherogenic properties of enzymatically degraded low density lipoprotein: Selective induction of MCP-1 and cytotoxic effects on human macrophages. Arterioscl Thromb Vasc Biol 1998;18: 1376-1385.
25. Isner JM, Kearney M, Bortman S, et al. Apoptosis in human atherosclerosis and restenosis. Circulation 1995;91:2703-2711.
26. Bjorkerud S, Bjorkerud B. Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability. Am J Pathol 1996; 149:367-380.
27. Torzewski M, Klouche M, Hock J. et al. Immunohistochemical demonstration of enzymatically modified human low density lipoprotein and its colocalization with the terminal complement complex in the early atherosclerotic lesion. Arterioscl Thromb Vasc Biol 1998;18;369-378.
28. Schmiedt W, Kinscherf R, Deigner HP, et al. Complement C6-deficiency protects against diet-induced atherosclerosis in rabbits. Arterioscl Thromb Vasc Biol 1998 (in press).
29. Hebert PR, Gaziano JM, Chan KS, et al. Cholesterol lowering with statin drugs, risk of stroke, and total mortality. JAMA 1997;278:313-321.