Effect of crystalloid administration on oxygen extraction in endotoxemic pigs

Journal of Applied Physiology

Volumn 85, Issue 5, 1998, Pages 1667-1675

  Gow, Kenneth W ^a   Phang, P Terry ^a,b   Tebbutt Speirs, Susan M ^a   English, John C ^a   Allard, Michael F ^a   Goddard, Christopher M ^a   Walley, Keith R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ST PAUL S HOSPITAL   (Canada)

Author keywords

Endotoxemia; Fluid administration; Oxygen consumption; Oxygen delivery; Septic shock

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTALLOID; ENDOTOXEMIA; FLUID BALANCE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PRIORITY JOURNAL; RESUSCITATION; SEPTIC SHOCK; SWINE;

EID: 0031769059     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.5.1667     Document Type: Article

References (38)

1. Allard, M. F., C. T. Kamimura, D. R. English, S. L. Henning, and B. R. Wiggs. Regional myocardial capillary erythrocyte transit time in the normal resting heart. Circ. Res. 72: 187-193, 1993.
2. Baile, E. M., P. D. Pare, R. W. Dahlby, and J. C. Hogg. Regional distribution of extravascular water and hematocrit in the lung. J. Appl. Physiol. 46: 937-942, 1979.
3. Barroso-Aranda, J., G. W. Schmid-Schonbein, B. W. Zweifach, and J. C. Mathison. Polymorphonuclear neutrophil contribution to induced tolerance to bacterial lipopolysaccharide. Circ. Res. 69: 1196-1206, 1991.
4. Beal, A. L., and F. B. Cerra. Multiple organ failure syndrome in the 1990s: systemic inflammatory response and organ dysfunction. JAMA 271: 226-233, 1994.
5. Bone, R. C., R. A. Balk, F. B. Cerra, R. P. Dellinger, A. M. Fein, W. A. Knaus, R. M. H. Schein, and W. J. Sibbald. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101: 1644-1655, 1992.
6. Connolly, H. V., L. A. Maginniss, and P. T. Schumacker. Transit time heterogeneity in canine small intestine: significance for oxygen transport. J. Clin. Invest. 99: 228-238, 1997.
7. Czer, L. S. C., and W. C. Shoemaker. Optimal hematocrit value in critically ill post-operative patients. Surg. Gynecol. Obstet. 117: 363-368, 1978.
8. Dantzker, D. Oxygen delivery and utilization in sepsis. Crit. Care Clin. 5: 81-98, 1989.
9. Ellman, H. Capillary permeability in septic patients. Crit. Care Med. 12: 629-633, 1984.
10. Fink, M. P., S. M. Cohn, P. C. Lee, H. R. Rothschild, Y. F. Deniz, H. Wang, and R. G. Fiddian-Green. Effect of lipopolysaccharide on intestinal intramucosal hydrogen ion concentration in pigs: evidence of gut ischemia in a normodynamic model of septic shock. Crit. Care Med. 17: 641-646, 1989.
11. Gee, M. H., and D. O. Williams. Effect of lung inflation on perivascular cuff fluid volume in isolated dog lung lobes. Microvase. Res. 17: 192-201, 1979.
12. Goddard, C. M., M. F. Allard, J. C. Hogg, and K. R. Walley. Myocardial morphometric changes related to decreased contractility after endotoxin. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H1446-H1452, 1996.
13. Gutierrez, G. Regional blood flow and oxygen transport: implications for the therapy of the septic patient. Crit. Care Med. 21: 1263-1264, 1993.
14. Gutierrez, G., F. Palizas, G. Doglio, N. Wainsztein, A. Gallisio, J. Pacin, A. Dubin, E. Schiavi, M. Jorge, J. Pusajo, F. Klein, E. S. Roman, B. Dorfman, J. Shottlender, and R. Giniger. Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 339: 195-199, 1992.
15. Hersch, M., A. A. Gnidec, A. D. Bersten, M. Troster, F. S. Rutledge, and W. J. Sibbald. Histologic and ultrastructural changes in nonpulmonary organs during early hyperdynamic sepsis. Surgery 107: 397-410, 1990.
16. Heughan, C., J. Niinisoski, and T. K. Hunt. Effect of excessive infusion of saline solution on tissue oxygen transport. Surg. Gynecol. Obstet. 135: 257-260, 1972.
17. Hogg, J. C., H. O. Coxson, M.-L. Brumwell, N. Beyers, C. M. Doerschuk, W. MacNee, and B. R. Wiggs. Erythrocyte and polymorphonuclear cell transit time and concentration in human pulmonary capillaries. J. Appl. Physiol. 77: 1795-1800, 1994.
18. Hogg, J. C., T. McLean, B. A. Martin, and B. Wiggs. Erythrocyte transit and neutrophil concentration in the dog lung. J. Appl. Physiol. 65: 1217-1225, 1988.
19. Honig, C. R., and C. L. Odoroff. Calculated dispersion of capillary transit times: significance for oxygen exchange. Am. J. Physiol. 240 (Heart Circ. Physiol. 9): H199-H208, 1981.
20. Humer, M. F., P. T. Phang, B. P. Friesen, M. F. Allard, C. M. Goddard, and K. R. Wally. Heterogeneity of gut capillary transit times and impaired gut oxygen extraction in endotoxemic pigs. J. Appl. Physiol. 81: 895-904, 1996.
21. Lam, C., K. Tyml, C. Martin, and W. Sibbald. Microvascular perfusion is impaired in a rat model of normotensive sepsis. J. Clin. Invest. 94: 2077-2083, 1994.
22. Morff, R. J. Contribution of capillary recruitment to regulation of tissue oxygénation in rat cremaster muscle. Microvasc. Res. 36: 150-161, 1988.
23. 2 uptake during bacteremia in dogs. J. Appl. Physiol. 63: 1487-1492, 1987.
24. 2 extraction in the dog. J. Appl. Physiol. 63: 387-394, 1987.
25. Ostgaard, G., and R. K. Reed. Interstitial fluid accumulation does not influence oxygen uptake in the rabbit small intestine. Acta Anaesthesiol. Scand. 39: 167-173, 1995.
26. Parker, M. M., J. H. Shelhamer, S. L. Bacharach, M. V. Green, C. Natanson, T. M. Fredrick, B. A. Damske, and J. E. Parrillo. Profound but reversible myocardial depression in patients with septic shock. Ann. Intern. Med. 100: 483-490, 1984.
27. Parrillo, J. E., M. M. Parker, C. Natanson, A. F. Suffredini, R. L. Danner, R. E. Cunnion, and F. P. Ognibene. Septic shock in humans: advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann. Intern. Med. 113: 227-242, 1990.
28. Piiper, J., and P. Haab. Oxygen supply and uptake in tissue models with unequal distribution of blood flow and shunt. Respir. Physiol. 84: 261-271, 1991.
29. Powell, R. J., G. W. Machiedo, and B. F. Rush, Jr. Decreased red blood cell deformability and impaired oxygen utilization during human sepsis. Am. Surg. 59: 65-68, 1993.
30. 2 delivery from experimental data: sensitivity to error. J. Appl. Physiol. 64: 2074-2082, 1988.
31. Schacterle, R. D., J. M. Adams, and R. J. Ribando. A theoretical model of gas transport between arterioles and tissue. Microvasc. Res. 41: 210-228, 1991.
32. Shepherd, A. P., and J. W. Kiel. A model of countercurrent shunting of oxygen in the intestinal villus. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H1136-H1142, 1992.
33. Tuchschmidt, J., D. Obltas, and J. C. Fried. Oxygen consumption in sepsis and septic shock. Crit. Care Med. 19: 664-671, 1991.
34. Tyml, K. Heterogeneity of microvascular flow in rat skeletal muscle is reduced by contraction and by hemodilution. Int. J. Microcirc. Clin. Exp. 10: 75-86, 1991.
35. 2 in endotoxemic dogs during shock and resuscitation. J. Appl. Physiol. 76: 793-800, 1994.
36. 2 extraction capabilities during acute hemorrhage. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H1942-H1947, 1993.
37. Walley, K. R. Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory. J. Appl. Physiol. 81: 885-894, 1996.
38. Weibul, E. R. Measuring through the microscope: development and evolution of stereological methods. J. Microsc. 155: 393-403, 1989.