O2 extraction maintains O2 uptake during submaximal exercise with β- adrenergic blockade at 4,300 m

Journal of Applied Physiology

Volumn 85, Issue 3, 1998, Pages 1092-1102

  Wolfel, Eugene E ^a   Selland, Mark A ^a   Cymerman, A ^b   Brooks, George A ^c   Butterfield, Gail E ^d   Mazzeo, Robert S ^e   Grover, Robert F ^a   Reeves, John T ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^e UNIVERSITY OF COLORADO   (United States)

Author keywords

High altitude; Oxygen transport

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; ISOPRENALINE; PLACEBO; PROPRANOLOL;

ADRENERGIC RECEPTOR BLOCKING; ADULT; ALTITUDE; ARTICLE; EXERCISE; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEMODYNAMIC PARAMETERS; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PHYSICAL ACTIVITY; PRIORITY JOURNAL; ANOXIA; BLOOD FLOW; BLOOD GAS ANALYSIS; CLINICAL TRIAL; CONTROLLED STUDY; DIET; DRUG EFFECT; HEMODYNAMICS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; ADULT; ALTITUDE; ANOXIA; BLOOD GAS ANALYSIS; DIET; EXERCISE; HEMODYNAMIC PROCESSES; HUMANS; ISOPROTERENOL; MALE; OXYGEN CONSUMPTION; PROPRANOLOL; REGIONAL BLOOD FLOW;

EID: 0031595531     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.85.3.1092     Document Type: Article

References (36)

1. Bevilacqua, M., S. Savonitto, E. Bosisio, E. Chebat, P. L. Bertora, M. Sardina, and G. Norbiato. Role of the Frank-Starling mechanism in maintaining cardiac output during increasing levels of treadmill exercise in β-blocked normal men. Am. J. Cardiol. 63: 853-857, 1989.
2. Butterfield, G. E., J. Gates, S. Fleming, G. A. Brooks, J. R. Sutton, and J. T. Reeves. Increased energy intake minimizes weight loss in men at high altitude. J. Appl. Physiol. 72: 1741-1748, 1992.
3. Clements, I. P., K. P. Offord, D. W. Baron, M. L. Brown, W. T. Bardsley, and C. E. Harrison, Jr. Cardiovascular hemodynamics of bicycle and handgrip exercise in normal subjects before and after administration of propranolol. Mayo Clin. Proc. 59: 604-611, 1984.
4. 2 dissociation in man during prolonged work in chronic hypoxia. J. Appl. Physiol. 38: 1022-1029, 1975.
5. Ekblom, B., A. N. Goldberg, A. Kilbom, and P. O. Astrand. Effects of atropine and propranolol on the oxygen transport system during exercise in man. Scand. J. Clin. Lab. Invest. 30: 35-42, 1972.
6. Epstein, S. E., B. F. Robinson, R. L. Kahler, and E. Braunwald. Effects of β-adrenergic blockade on the cardiac response to maximal and submaximal exercise in man. J. Clin. Invest. 44: 1745-1753, 1965.
7. Fulco, C. S., A. Cymerman, J. T. Reeves, P. B. Rock, L. A. Trad, and P. M. Young. Propranolol and the compensatory circulatory responses to orthostasis at high altitude. Aviat. Space Environ. Med. 60: 1049-1055, 1989.
8. Fulco, C. S., P. B. Rock, J. T. Reeves, L. A. Trad, P. M. Young, and A. Cymerman. Effects of propranolol on acute mountain sickness (AMS) and well-being at 4,300 meters of altitude. Aviat. Space Environ. Med. 60: 679-683, 1989.
9. Gonzalez, N. C., R. L. Clancy, and P. D. Wagner. Determinants of maximal oxygen uptake in rats acclimated to simulated altitude. J. Appl. Physiol. 75: 1608-1614, 1993.
10. Hughson, R. L., Y. Yamamoto, R. E. McCullough, J. R. Sutton, and J. T. Reeves. Sympathetic and parasympathetic indicators of heart rate control at altitude studied by spectral analysis. J. Appl. Physiol. 77: 2537-2542, 1994.
11. Joyner, M. J., B. J. Freund, S. M. Jilka, G. A. Hetrick, E. Martinez, G. A. Ewy, and J. H. Wilmore. Effects of β-blockade on exercise capacity of trained and untrained men: a hemodynamic comparison. J. Appl. Physiol. 60: 1429-1434, 1986.
12. Kaiser, P. Running performance as a function of the dose-response relationship to β-adrenoceptor blockade. Int. J. Sports Med. 3: 29-32, 1982.
13. Kelbaek, H., O. J. Hartling, T. Gjorup, J. Marving, N. J. Christensen, and J. Godtfredsen. Effects of autonomic blockade on cardiac function at rest and during upright exercise in humans. J. Appl. Physiol. 63: 554-557, 1987.
14. Lundborg, P., H. Astrom, C. Bengtsson, E. Fellenius, H. von Schenck, L. Svensson, and U. Smith. Effect of β-adrenoceptor blockade on exercise performance and metabolism. Clin. Sci. 61: 299-305, 1981.
15. Maher, J. T., S. C. Manchanda, A. Cymerman, D. L. Wolfe, and L. H. Hartley. Cardiovascular responsiveness to β-adrenergic stimulation and blockade in chronic hypoxia. Am. J. Physiol. 228: 477-481, 1975.
16. Mazzeo, R. S., P. R. Bender, G. A. Brooks, G. E. Butterfield, B. M. Groves, J. R. Sutton, E. E. Wolfel, and J. T. Reeves. Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure. Am. J. Physiol. 261 (Endocrinol. Metab. 24): E419-E424, 1991.
17. Mazzeo, R. S., G. A. Brooks, G. E. Butterfield, A. Cymerman, A. C. Roberts, M. Selland, E. E. Wolfel, and J. T. Reeves. β-Adrenergic blockade does not prevent the lactate response to exercise after acclimatization to high altitude. J. Appl. Physiol. 76: 610-615, 1994.
18. Mazzeo, R. S., G. A. Brooks, G. E. Butterfield, D. A. Podolin, E. E. Wolfel, and J. T. Reeves. Acclimatization to high altitude increases muscle sympathetic activity both at rest and during exercise. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R201-R207, 1995.
19. Mazzeo, R. S., E. E. Wolfel, G. E. Butterfield, and J. T. Reeves. Sympathetic response during 21 days at high altitude (4,300 m) as determined by urinary and arterial catecholamines. Metabolism 43: 1226-1232, 1994.
20. Moore, L. G., A. Cymerman, S. Huang, R. E. McCullough, R. G. McCullough, P. B. Rock, A. Young, P. M. Young, D. Bloedow, J. V. Weil, and J. T. Reeves. Propranolol does not impair exercise oxygen uptake in normal men at high altitude. J. Appl. Physiol. 61: 1935-1941, 1986.
21. Moore, L. G., A. Cymerman, S. Huang, R. E. McCullough, R. G. McCullough, P. B. Rock, A. Young, P. Young, J. V. Weil, and J. T. Reeves. Propranolol blocks metabolic rate increase but not ventilatory acclimatization to 4,300 m. Respir. Physiol. 70: 195-204, 1987.
22. Petersen, E. S., B. J. Whipp, J. A. Davis, D. J. Huntsman, H. V. Brown, and K. Wasserman. Effects of β-adrenergic blockade on ventilation and gas exchange during exercise in humans. J. Appl. Physiol. 54: 1306-1313, 1983.
23. Reeves, J. T., B. M. Groves, A. Cymerman, J. R. Sutton, P. D. Wagner, D. Turkevich, and C. S. Houston. Operation Everest II: cardiac filling pressures during cycle exercise at sea level. Respir. Physiol. 80: 147-154, 1990.
24. Reybrouck, T., A. Amery, and L. Billiet. Hemodynamic response to graded exercise after chronic β-adrenergic blockade. J. Appl. Physiol. 42: 133-138, 1977.
25. Richalet, J. P., P. Larmignat, C. Rathat, A. Keromes, P. Baud, and F. Lhoste. Decreased cardiac response to isoproterenol infusion in acute and chronic hypoxia. J. Appl. Physiol. 65: 1957-1961, 1988.
26. Richardson, D. W., H. A. Kontos, A. J. Raper, and J. L. Patterson, Jr. Modification by β-adrenergic blockade of the circulatory response to acute hypoxia in man. J. Clin. Invest. 46: 77-85, 1967.
27. Roberts, A. C., G. E. Butterfield, A. Cymerman, J. T. Reeves, E. E. Wolfel, and G. A. Brooks. Acclimatization to 4,300 m altitude decreases reliance on fat as substrate. J. Appl. Physiol. 81: 1762-1771, 1996.
28. Roberts, A. C., J. T. Reeves, G. E. Butterfield, R. S. Mazzeo, J. R. Sutton, E. E. Wolfel, and G. A. Brooks. Altitude and β-blockade augment glucose utilization during submaximal exercise. J. Appl. Physiol. 80: 605-615, 1996.
29. Saltin, B., R. F. Grover, C. G. Blomqvist, L. H. Hartley, and R. L. Johnson, Jr. Maximal oxygen uptake and cardiac output after 2 weeks at 4,300 m. J. Appl. Physiol. 25: 400-409, 1968.
30. Sutton, J. R., J. T. Reeves, P. D. Wagner, B. M. Groves, A. Cymerman, M. K. Malconina, P. B. Rock, P. M. Young, S. D. Walter, and C. S. Houston. Operation Everest II: oxygen transport during exercise at extreme simulated altitude. J. Appl. Physiol. 64: 1309-1321, 1988.
31. 2 uptake during submaximal and maximal exercise. J. Appl. Physiol. 54: 901-905, 1983.
32. Van Baak, M. A. β-Adrenoceptor blockade and exercise - an update. Sports Med. 4: 209-225, 1988.
33. Voelkel, N. F., L. Hegstrand, J. T. Reeves, I. F. McMurtry, and P. B. Molinoff. Effects of hypoxia on density of β-adrenergic receptors. J. Appl. Physiol. 50: 363-366, 1981.
34. Wilmore, J. H., B. J. Freund, M. J. Joyner, G. A. Hetrick, A. A. Hartzell, R. T. Strother, G. A. Ewy, and W. E. Faris. Acute response to submaximal and maximal exercise consequent to β-adrenergic blockade: implications for the prescription of exercise. Am. J. Cardiol. 55: 135D-141D, 1985.
35. Wolfel, E. E., B. M. Groves, G. A. Brooks, G. E. Butterfield, R. S. Mazzeo, L. G. Moore, J. R. Sutton, P. R. Bender, T. E. Dahms, R. E. McCullough, R. G. McCullough, S. Huang, S. Sun, R. F. Grover, H. N. Hultgren, and J. T. Reeves. Oxygen transport during steady-state submaximal exercise in chronic hypoxia. J. Appl. Physiol. 70: 1129-1136, 1991.
36. Wolfel, E. E., W. R. Hiatt, H. L. Brammell, V. Travis, and L. D. Horwitz. Plasma catecholaminc responses to exercise after training with β-adrenergic blockade. J. Appl. Physiol. 68: 586-593, 1990.