Naturally processed peptides from HLA-DQ7 (α1*0501-β1*0301): Influence of both α and β chain polymorphism in the HLA-DQ peptide binding specificity

European Journal of Immunology

Volumn 28, Issue 11, 1998, Pages 3840-3849

  Khalil Daher, Iman ^a   Boisgérault, Florence ^a   Feugeas, Jean Paul ^a   Tieng, Vannary ^a   Toubert, Antoine ^a   Charron, Dominique ^a,b  

^a SAINT LOUIS HOSPITAL   (France)

^b INSERM   (France)

Author keywords

Autoimmune disease; Binding motif; HLA class II peptide; HLA DQ7

Indexed keywords

DNA; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; MEMBRANE PROTEIN; TRANSFERRIN RECEPTOR;

ALLELE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA POLYMORPHISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ALLELES; AMINO ACID SEQUENCE; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; POLYMORPHISM, GENETIC; RECEPTORS, TRANSFERRIN;

EID: 0031767115     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199811)28:11<3840::AID-IMMU3840>3.0.CO;2-T     Document Type: Article

References (36)

1. Shimonkevitz, R., Colon, S., Kappler, J. W., Marrack, P. and Grey, H. M., Antigen recognition by H-2 restricted T cells. II. Tryptic ovalbumin peptide that substitutes for processed antigen. J. Immunol. 1984. 133: 2067-2074.
2. Germain, R. N., MHC-dependent antigen processing and peptide presentation/providing ligands for T lymphocyte activation. Cell 1994. 76: 287-299.
3. Brown, J. H., Jardetzky, T. S., Gorga, J. C., Stern, L. J., Urban, R. G., Strominger, J. L. and Wiley, D. C., Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature 1993. 364: 33-39.
4. Stern, L. J., Brown, J. H., Jardetzky, T. S., Gorga, J. C., Urban, R. G., Strominger, J. L. and Wiley, D. C., Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenzy virus peptide. Nature 1994. 368: 215-221.
5. Ghosh, P., Amaya, M., Mellins, E. and Willey, D. C., The structure of an intermediate in class II MHC maturation/Clip bound to HLA-DR3. Nature 1995. 378: 457-462.
6. k in complex with a dominant epitope of lysozyme. Immunity 1998. 8: 305-3318.
7. d-peptide complexes reveal that high affinity can be achieved without large anchor residues. Immunity 1998. 8: 319-329.
8. O'Sullivan, D., Sindey, J., Appella, E., Walker, L., Phillips, L., Colon, S. M., Miles, C., Chesnut, R. W. and Sette, A., Characterization of the specificity of peptide binding to four DR haplotypes. J. Immunol. 1990. 145: 1799-1808.
9. Sette, A., Ceman, S., Kubo, R. T., Sakaguchi, K., Appella, E., Hunt, D. F., Davis, T. A., Michel, H., Shabanowitz, J., Rudersdof, R., Grey, H. M. and DeMars, R., Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant. Science 1992. 258: 1801-1804.
10. Chicz, R. M., Urban, R. G., Gorga, J. C., Vignali, D. A. A., Lane, W. S. and Strominger, J. L., Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J. Exp. Med. 1993. 178: 27-47.
11. Melcherek, G., Falk, K., Rötzschke, O., Rammensee, H. G., Stevanovic, S., Gnau, V., Jung, G. and Melms, A., Natural peptide ligand motifs of two HLA molecules associated with myasthenia gravis. Int. Immunol. 1993. 5: 1229-1237.
12. Kropshofer, H., Max, H., Halder, T., Kaibus, M., Muller, C. and Kalbacjer, H., Self-peptides from four HLA-DR alleles share hydrophobic anchor residues near the NH2-terminal including prolin as a stop signal for trimming. J. Immunol. 1993. 151: 4732-4742.
13. Hammer, J., Valsasnini, P., Tolba, K., Bolin, D., Higelin, J., Takaes, B. and Sinigaglia, F., Promiscuous and allele-specific anchors in HLA-DR-binding peptides. Cell 1993. 74: 197-203.
14. Vogt, A. B., Kropshofer, H., Kalbacher, H., Kalbus, M., Rammensee, H. G., Coligan, J. E. and Martin, R., Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides. J. Immunol. 1994. 153: 1665-1673.
15. Marshall, K. W., Liu, A. F., Canales, J., Perahia, B., Jorgensen, B., Gantzos, R. D., Aguilar, B., Devaux, B. and Rothbard, J. B., Role of the polymorphic residues in HLA-DR molecules in allele-specific binding of peptide ligand. J. Immunol. 1994. 152: 4946-4957.
16. Verreck, F. A., van de Poel, A., Termijtelen, A., Amons, R., Drijfhout, J. W. and Koning, F., Identification of an HLA-DQ2 peptide binding motif and HLA-DPw3-bound self-peptide by pool sequencing. Eur. J. Immunol. 1994. 24: 375-379.
17. Chicz, R. M., Lane, W. S., Robinson, R. A., Trucco, M., Strominger, J. L. and Gorga, J. C., Self-peptide bound to the types I diabetes-associated class II MHC molecules HLA-DQ1 and HLA-DQ8. Int. Immunol. 1994. 6: 1639-1649.
18. Falk, K., Rötzschke, O., Stevanovic, S., Jung, G. and Rammensee, H. G., Pool sequencing of natural HLA-DR, DQ, and DP ligands reveals detailed peptide motifs, constraints of processing, and general rules, Immunogenetics 1994. 39: 230-242.
19. Sidney, J., Oseroff, C., del Guercio, M. F., Southwood, S., Krieger, J. I., Ishioka, G. Y., Sakaguchi, K., Appella, E. and Sette, A., Definition of a DQ3.1-specific binding motif. J. Immunol. 1994. 152: 4516-4525.
20. Kwok, W. W., Domeier, M. E., Raymond, F. C., Byers, P. and Nepom, G. T., Allele-specific motifs characterize HLTV-DQ interactions with a diabetes-associated peptide derived from glutamic acid decarboxylase. J. Immunol. 1996. 156: 2171-2177.
21. Vardtal, F., Johansen, B. H., Friee, T., Thorpe, C. J., Stevanovic, S., Eriksen, J. E., Sletten, K., Thorsby, E., Rammensee, H. G. and Sollid, L. M., The peptide binding motif of the disease-associated HLA-DQ (α1*0501-β1*0201) molecule. Eur. J. Immunol. 1996. 26: 2764-2777.
22. Todd, J. A., Bell, J. I. and McDevitt, H. O., HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 1987. 329: 599-604.
23. Khalil, I., D'Auriol, L., Gobet, M., Morin, L., Lepage, V., Deschamps, I., Park, M. S., Degos, L. and Hors, J., A combination of HLA-DQβ Asp57 negative and HLA-DQα Arg52 confer susceptibility to insulin-dependent diabetes mellitus. J. Clin. Invest. 1990. 8: 1315-1319.
24. Nepom, G. T. and Erlich, H., MHC class-II molecules and autoimmunity. Annu. Rev. Immunol. 1991. 9: 493-525.
25. Khalil, I., Deschamps, I., Lepage, V., Al-Daccak, R., Degos, L. and Hors, J., Dose effect of cis and trans encoded HLA-Dαβ heterodimers in IDDM susceptibility. Diabetes 1992. 4: 378-384.
26. Thorsby, E., HLA-associated disease susceptibility -which genes are primarily involved? The Immunologist 1995. 3: 51-58.
27. Chicz, R. M., Graziano, D. F., Trucco, M., Strominger, J. L. and Gorga, J. C., HLA-DP2, self peptide sequences and binding properties. J. Immunol. 1997. 159: 4935-4942.
28. Johansen, B. H., Jensen, T., Thorpe, C. J., Vartdal, F., Thorsby, E. and Sollid, L. M., Both alpha and beta chain polymorphisms determine the specificity of the disease-associated HLA-DQ molecules, with beta chain residues being most influential, Immunogenetics 1996. 45: 142-150.
29. Kwok, W. W., Nepom, G. T. and Raymond, F. C., HLA-DQ polymorphisms are highly selective for peptide binding interactions. J. Immunol. 1995. 155: 2468-2476.
30. Raddrizzani, L., Sturniolo, T., Guenot, J., Bono, E., Gallazzi, F., Nagy, Z. A., Sinigaglia, F. and Hammer, J., Different modes of peptide interaction enable HLA-DQ and HLA-DR molecules to bind diverse peptide repertoires. J. Immunol. 1997. 159: 703-711.
31. Busch, R., Hill, C. M., Hayball, J. D., Lamb, J. R. and Rothbard, J. B., Effect of natural polymorphism at residue 86 of the HLA-DR beta chain on peptide binding. J. Immunol. 1991. 147: 1292-1298.
32. Demtoz, S., Barbey, C., Carradin, G., Amoroso, A. and Lanzavecchia, A., The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86. Eur. J. Immunol. 1993. 23: 425-432.
33. Newton-Nash, D. K. and Eckels, D. D., Differential effect of polymorphism at HLA-DR1 a chain position 85 and 86 on binding and recognition of DR1 restricted antigenie peptides. J. Immunol. 1993. 153: 1813-1821.
34. Undlien, E., Akelsen, H. F., Joner, G., Dahl-Jorgensen, K., Sovik, O., Ronningen, K. S. and Thorsby, E., HLA-encoded genetic predisposition in IDDM: DR4 subtypes may be associated with different degrees of protection. Diabetes 1997. 46: 143-149.
35. Feugeas, J. P., Tortosa, P., Dulay, S., Augustin-Pascalis, I., Charron, D., Krishnamoorthy, R., Caillens, H. and Montchamps-Moreau, C., Analysis of HLA haplotypes in families with type I doabetes mellitus in La Reeunion island. Eur. J. Immunogenet. 1996. 2: 459-470.
36. Boisgérault, F., Khalil, I., Tieng, V., Connan, F., Tabary, T., Cohen, J. H. M., Choppin, J., Charron, D. and Toubert, A., Definition of the HLA-A29 peptide ligand motif allows to predict potential T cell epitopes from the retina S antigen, an autoantigen associated with birdshot retinopathy. Proc. Natl. Acad. Sci. USA 1996. 93: 3466-3470.