Thrombin receptor activation elicits rapid protein tyrosine phosphorylation and stimulation of the Raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells. Evidence for an obligate autocrine mechanism promoting cell proliferation induced by G protein-coupled receptor agonists

Journal of Clinical Investigation

Volumn 97, Issue 5, 1996, Pages 1173-1183

  Molloy, Christopher J ^a,c   Pawlowski, John E ^a   Taylor, David S ^a   Turner, Christopher E ^b   Weber, Helen ^a   Peluso, Marianne ^a   Seiler, Steven M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^c BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

Atherosclerosis; Basic fibroblast growth factor; Platelet derived growth factor; Restenosis; Smooth muscle

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; NEUTRALIZING ANTIBODY; PLATELET DERIVED GROWTH FACTOR; THROMBIN; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE; TYROSINE;

ANIMAL CELL; AORTA ATHEROSCLEROSIS; ARTERY OCCLUSION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; FIBRIN CLOT; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL DIVISION; CELLS, CULTURED; FIBROBLAST GROWTH FACTOR 2; GTP-BINDING PROTEINS; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RATS; RECEPTORS, THROMBIN; THROMBIN; TYROSINE;

EID: 0029865197     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118531     Document Type: Article

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