Similarities of cutaneous and breast pathology in Cowden's syndrome

Experimental Dermatology

Volumn 7, Issue 6, 1998, Pages 380-390

  Schrager, Carolina A ^a,b,d   Schneider, Douglas ^a,c   Gruener, Alexandra C ^d   Tsou, Hui C ^d   Peacocke, Monica ^d,e  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c ST ELIZABETH'S MEDICAL CENTER   (United States)

^d College of Physicians and Surgeons ^*  (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Breast cancer; Cowden's Syndrome; Fibrosis; Keloids; Sclerotic nodules

Indexed keywords

ADULT; AGED; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BREAST CANCER; CANCER RISK; CLINICAL ARTICLE; COWDEN SYNDROME; FEMALE; FIBROSIS; HAMARTOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYALINE DEGENERATION; KELOID; SKIN BIOPSY; SKIN CANCER;

EID: 0031766247     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0625.1998.tb00338.x     Document Type: Article

References (28)

1. Lloyd K M, Dennis M. Cowden's syndrome. A possible new symptom complex with multiple system involvement. Ann Intern Med 1963: 58: 136-142.
2. Weary P E, Gorlin R J, Gentry W C, Comer J E, Greer K. Multiple hamartoma syndrome (Cowden's disease). Arch Dermatol 1972: 106: 682-690.
3. Brownstein M H, Wolf M, Bikowski J B. Cowden's disease - a cutaneous marker of breast cancer. Cancer 1978: 41: 2393-2398.
4. Salem O S, Steck W D. Cowden s disease (multiple hamartoma syndrome and neoplasia syndrome). J Am Acad Dermatol 1983: 8: 686-696.
5. Starink T M, Van Der Veen J P W, Arwert F et al. The Cowden's syndrome: a clinical and genetic study in 21 patients. Clin Genet 1986: 29: 222-233.
6. Schrager C A, Schneider D, Gruener A C, Tsou H C. Peacocke M. Clinical and pathological features of breast disease in Cowden's Syndrome: An underrecognized syndrome with an increased risk of breast cancer. Hum Pathol 1998: 29: 47-53.
7. Nelen M R, Padberg G W, Peeters E A J et al. Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet 1996: 13: 114-116.
8. Li J, Yen C, Liaw D et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997. 275. 1943-1947.
9. Liaw D, Liaw D, Marsh D J et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 1997: 6: 4-67.
10. Steck P A, Pershouse M A, Jasser S A et al. Identification a candidate tumour suppressor gene, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997: 15: 356-362.
11. Li D, Sun H. TEPI, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor β. Cancer Res 1997: 57: 2124-2129.
12. Tsou H C, Teng D H F, Ping et al. Mutations in MMACI in early onset breast cancer associated with Cowden Syndrome and absence of mutations in other individuals with early onset breast cancer. Am J Hum Genet 1997: 61: 1036-1043.
13. Tsou H C, Ping X L, Xie X X et al. The genetic basis of Cowden s Syndrome: Three novel mutations in PTEN/MMAC1/TEP1, Hum Genet, in press.
14. Krieger N, Hiatt R A. Risk of breast cancer after benign diseases. Variation by histologic type, degree of atypia, age at biopsy, and length of follow-up. Am J Epidemiol 1992: 135: 619-631.
15. Nelen M R, van Staveren W C G, Peeters E A J et al. Germline mutations in the PTEN/MMACI gene in patients with Cowden disease. Hum Mol Genet 1997: 6: 1383-1387.
16. Kern W H, Clark R W. Retrogression of fibroadenomas of the breast. Am J Surg 1973: 126: 59-62.
17. Tomaszewski J E, Brooks J S J, Hicks D, Livolsi V A. Diabetic mastopathy: a distinctive clinicopathologic entity. Hum Pathol 1992: 23: 780-786.
18. Byrd B F, Hartmann W H, Graham L S, Hogle H H. Mastopathy in insulin-dependent diabetics. Ann Surg 1987: 205: 529-532.
19. Cowan D F, Herbert T A. Involution of the breast in women aged 50 to 104 years: a histopathological study of 102 cases. Surg Pathol 1989: 2: 323-333.
20. Arrigoni M G, Dockerty M B, Judd E S. The identification and treatment of mammary hamartoma. Surg Gynecol Obstet 1971: 133: 577-582.
21. Petrick P K. Mammary hamartoma. Am J Surg Pathol 1987: 11: 234-235.
22. Oberman H A. Hamartomas and hamartoma variants of the breast. Semin Diagn Pathol 1989: 6: 135-145.
23. Daya D, Trus T, D'Souza T J, Minuk T, Yemen B. Hamartoma of the breast, an underrecognized breast lesion. Anat Pathol 1994: 103: 685-689.
24. Fisher C J, Hanby A M, Robinson L, Millis R R. Mammary hamartoma - a review of 35 cases. Histopathology 1992: 20: 99-106.
25. Hanson C A, Snover D C, Dehner L P. Fibroadenomatosis (fibroadenomatoid mastopathy): a benign breast lesion with composite pathologic features. Pathology 1987: 19: 393-396.
26. Dupont W D, Page D L, Parl F F et al. Long-term risk of breast cancer in women with fibroadenoma. N Engl J Med 1994: 331: 10-15.
27. Cuyne J, Hobbs F M, Boggis C Harland R. Lobular carcinoma in a mammary hamartoma. J Clin Pathol 1992: 45: 936-937.
28. Diaz N M, Palmer J O, McDivitt R W. Carcinoma arising within fibroadenomas of the breast: A clinicopathologic study of 105 patients. Am J Clin Pathol 1991: 95: 614-622.