Effect of adrenalectomy on the slimming activity of liposome-carried oleoyl-estrone in the rat

International Journal of Obesity

Volumn 22, Issue 12, 1998, Pages 1225-1230

  Grasa, M M ^a,b   Cabot, C ^a,b   Adan C ^a,b   Vila R ^b   Esteve, M ^a,b   Estruch, J ^a   Fernandez Lopez J A ^b   Remesar, X ^b   Alemany, M ^b  

^a Laboratoris SALVAT SA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Adrenalectomy; Glucocorticoids; Leptin; Obesity; Oleoyl estrone; Slimming

Indexed keywords

CORTICOSTERONE; ESTRONE; ESTRONE OLEATE; GLUCOCORTICOID; GLUCOSE; INSULIN; LEPTIN; LIPOSOME; UNCLASSIFIED DRUG; UREA;

ADRENALECTOMY; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; UREA BLOOD LEVEL; WEIGHT REDUCTION;

ANIMALIA;

EID: 0031766002     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0800751     Document Type: Article

References (48)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-431.
2. Rentsch J, Levens N, Chiesi M. Recombinant ob-gene product reduces food intake in fasted mice. Biochem Biophys Res Commun 1995; 214: 131-136.
3. Seeley RJ, Van Dijk G, Campfield LA, Smith FJ, Burn P, Nelligan JA, Bell SM, Baskin DG, Woods SC, Schwartz MW. Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm Metab Res 1996; 28: 664-668.
4. Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-1188.
5. Hwa JJ, Ghibaudi L, Compton D, Fawzi AB, Strader CD. Intracerebroventricular injection of leptin increases thermogenesis and mobilizes fat metabolism in ob/ob mice. Horm Metab Res 1966; 28: 659-663.
6. Sanchis D, Balada F, Grasa MM, Virgili J, Peinado J, Monserrat C, Fernández-López JA, Remesar X, Alemany M. Oleoyl-estrone induces the loss of body fat in rats. Int J Obes 1996; 20: 588-594.
7. Sanchis D, Balada F, Picó C, Grasa MM, Virgili J, Farrerons C, Palou A, Fernández-López JA, Remesar X, Alemany M. Rats receiving the slimming agent oleoyl-estrone in liposomes (Merlin-2) decrease food intake but maintain thermogenesis. Arch Physiol Biochem 1997; 105: 663-672.
8. Balada F, Sanchis D, Grasa MM, Virgili J, Estruch J, Fernández-López JA, Remesar X, Alemany M. Effect of the slimming agent oleoyl-estrone in liposomes on the body weight of Zucker obese rats. Int J Obes 1997; 21: 789-895.
9. Balada F, Sanchis D, Virgili J, Grasa MM, Monserrat C, Fernández-López JA, Remesar X, Alemany M. Effect of the slimming agent oleoyl-estrone in liposomes (Merlin-2) on the body weight of rats fed a cafeteria diet. Arch Physiol Biochem 1997; 105: 487-495.
10. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-295.
11. Fernández-Real JM, Sanchis D, Ricart W, Casamitjana R, Castañer MF, Soler J, Alemany M. Is oleoyl-estrone a ponderostat signal in humans? Int J Obes 1997; 21 (suppl 2): S74 (abstract)
12. Sanchis D, Adán A, Ardévol A, Grasa MM, Cabot C, Balada F, Vilà R, Estruch J, Puerta ML, Fernández-López JA, Remesar X, Alemany M. Short-term treatment with oleoyl-estrone in liposomes (Merlin-2) strongly reduces the expression of the ob gene in young rats. Biochem J 1997; 326: 357-360.
13. Cabot C, Grasa MM, Estruch J, Fernández-López JA, Remesar X, Alemany M. Zucker. Obese rats are insentitive to the CRH-increasing effect of oleoyl-estrone. Brain Res.Bull. 1998; 46: (in press).
14. Björntorp P. Endocrine abnormalities of obesity. Metabolism 1995; 44 (Suppl. 3): 21-23.
15. Dubuc PU. Interactions between insulin and glucocorticoids in the maintenance of genetic obesity. Am J Physiol 1992; E550-E555.
16. Onai T, Kilroy G, York DA, Bray GA. Regulation of B3-adrenergic receptor mRNA by sympathetic nerves and glucocorticoids in BAT of Zucker obese rats. Am J Physiol 1995; 269: R519-R526.
17. Sainsbury A, Cusin I, Rohner-Jeanrenaud F, Jeanrenaud B. Adrenalectomy prevents the obesity syndrome produced by-chronic central Neuropeptide Y infusion in normal rats. Diabetes 1997; 46: 209-214.
18. Bazin R, Planche E, Dupuy F, Krief S, Lavau M. Deprivation of corticosterone does not prevent onset of obesity in Zucker fa/fa rat. Am J Physiol 1987; 252: E461-E466.
19. Feldkircher KM, Mistry AM, Romsos DR. Adrenalectomy reverses pre-existing obesity in adult genetically obese (ob/ob) mice. Int J Obes 1996; 20: 232-235.
20. Westphal U. Steroid protein interactions I. Monographs on Endocrinology, Vol 4. 1971, Springer-Verlag: New York, pp 375-433.
21. Siiteri PK, Murai JT, Hammond GL, Misker JA, Raymoure WJ, Kuhn RW. The serum transport of steroid hormones. Rec Progr Horm Res 1982; 38: 457-510.
22. Hammond GL, Smith CL. Hormonal regulation of corticosteroid-binding globulin biosynthesis in the male rat. Endocrinology 1992; 130: 2245-2251.
23. Padridge WM. Transport of protein-bound hormones into tissues in vivo. Endocr Rev 1981; 2: 103-116.
24. Björntorp P. The regulation of adipose tissue distribution in humans. Int J Obes 1996; 20: 291-302.
25. Tokuyama K, Himms-Hagen J. Enhanced acute response to corticosterone in genetically-obese (ob/ob) mice. Am J Physiol 1989; 257: E133-E138.
26. McEwen BS, Wallach G, Magnus C. Corticosterone binding to hipoccampus: immediate and delayed influences of the absence of adrenal secretion. Brain Res 1974; 70: 321-334.
27. Devenport L, Knehans A, Thomas T, Sundstrom A. Corticosterone's dual metabolic actions. Life Sci 1989; 45: 1389-1396.
28. Flier JS. The adipocyte: storage depot or node on the energy information superhighway? Cell 1995; 80: 15-18.
29. Fève B, Baude B, Krief S, Strosberg AD, Pairault J, Emorine LJ. Inhibition by dexamethasone of B3-adrenergic receptor responsiveness in 3T3-F442A adipocytes. J Biol Chem 1992; 267: 15909-15915.
30. Turnbow MA, Keller SR, Rice MK, Garner CW. Dexamethasone down-regulation of insulin receptor substrate -1 in 3T3-L1 adipocytes. J Biol Chem 1994; 269: 2516-2520.
31. De Vos P, Saladin R, Auwerx J, Taels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 1995; 270: 15958-15961.
32. Mellon-Nussbaum SH, Ponticorvo L, Schatz F, Hochberg RS. Estradiol fatty acid esters. J Biol Chem 1982; 257: 5678-5684.
33. Good CA, Kramer H, Somogyi M. The purification of glycogen. J Biol Chem 1933; 100: 485-491.
34. Serafini MT, Alemany M. A micromethod for the enzymatic estimation of the degree of ramification of glycogen. J Biochem Biophys Meth 1987; 15: 33-39.
35. Folch J, Lees M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1957; 232: 497-509.
36. Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 1969; 6: 24-27.
37. Heding LG. Determination of total serum insulin (IRI) in insulin treated diabetic patients. Diabetologia 1972; 8: 260-266.
38. Rothwell NJ, Stock MJ. Influence of adrenalectomy on age-related-changes in energy-balance, thermogenesis and brown fat activity in the rat. Comp Biochem Physiol 1988; 89A: 265-269.
39. Slicker LJ, Sloop KW, Surface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey J, Stephens TW. Regulation of expression of ob niRNA and protein by glucocorticoids and cAMP. J Biol Chem 1996; 271: 5301-5304.
40. Zakrzewska KE, Cusin I, Sainsbury A, Rohner-Jeanrenaud F, Jeanrenaud B. Glucocorticoids as counterregulatory hormones of leptin - Toward an understanding of leptin resistance. Diabetes 1997; 46: 717-719.
41. Maffei M, Halaas J, Ravussin F, Pratley RE, Lee GH, Zhang Y, Fey H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JF. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995; 1: 115-116.
42. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K. Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 1996; 222: 19-26.
43. Phillips MS, Liu QY, Hammond HA, Dugan V, Hey PJ, Caskey CT, Hess JF. Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 1996; 13: 18-19.
44. Rafecas J, Esteve M, Fernández-López JA, Remesar X, Alemany M. Water balance in Zucker obese rats. Comp Biochem Physiol 1993; 104A: 813-818.
45. Brunner L, Nick HP, Cumin F, Chiesi M, Baum HP, Whitebread S, Strickerkrongrad A, Levens N. Leptin is a physiologically important regulator of food intake. Int J Obes 1997; 21: 1152 1160.
46. Blundell J. Pharmacological approaches to appetite suppression. Trends Pharmacol Sci 1991; 12: 147-157.
47. Albeck DS, Hastings NB, Mcewen BS. Effects of adrenalectomy and type I or type II glucocorticoid receptor activation on AVP and CRH mRNA in the rat hypothalamus. Mol Brain Res 1994; 26: 129-134.
48. Krahn DD, Gosnell BA, Majchrzak MJ. The anorectic effects of CRH and restraint stress decrease with repeated exposures. Biol Psychiatry 1990; 27: 1094-1102.