Evidence that phosphatidylinositol 3-kinase and p70(S6K) protein are involved in differentiation of HL-60 cells induced by calcitriol

Anticancer Research

Volumn 18, Issue 5 A, 1998, Pages 3507-3514

  Marcinkowska, Ewa ^a,b   Wiedlocha, Antoni ^b   Radzikowski, Czeslaw ^a  

^a INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Calcitriol; Differentiation; Inhibitors; MAP kinase; P13 kinase; P70(S6K) protein kinase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CALCITRIOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; THAPSIGARGIN; WORTMANNIN;

ARTICLE; CELL DIFFERENTIATION; CELL NUCLEUS; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN TRANSPORT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD11; ANTIGENS, CD14; BIOLOGICAL MARKERS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCITRIOL; CALCIUM CHANNEL AGONISTS; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME INHIBITORS; HL-60 CELLS; HUMANS; INDOLES; MALEIMIDES; PROTEIN KINASE C; RIBOSOMAL PROTEIN S6 KINASES; THAPSIGARGIN;

EID: 0031761175     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. 3, retinoic acid and DMSO. Leukemia Res 19: 57-64, 1995.
2. 3: comparison with the maturation of normal monocytic and granulocytic bone marrow cells. J Leukocyte Biol 58: 547-555, 1995.
3. S6K activation mediated by phosphatydylinositol-3-OH kinase. Nature 370: 71-75, 1994.
4. 3 stimulates expression and translocation of Protein Kinase Cα and Cδ via nongenomic mechanism and rapidly induces phosphorylation of a 33-kDa protein in acute promyelocytic NB4 cells. J Biol Chem 271: 16090-16096, 1996.
5. Walters MR: Newly identified actions of the vitamin D endocrine system. Endocrine Rev 13: 719-764, 1992.
6. Kesley SM, Newland AC and Makin HIJ: Vitamin D and human leukemia. Br J Haematol 71: 173-176, 1989.
7. Munker R, Kobayashi T, Elstner E, Norman AW, Uskokovic M, Zhang W, Andreef M and Koeffler HP: A new series of vitamin D analogs is higly active for clonal inhibition, differentiation and induction of WAF1 in myeloid leukemia. Blood 88: 2201-2209, 1996.
8. 3. Biochem. J 316: 361-371, 1996.
9. 3 regulates pp60c-src activity and expression of a pp60c-src activating phosphatase. J Cell Biochem 67: 432-438, 1997.
10. 3 primes acute promyelocytic cells for TPA-induced monocytic differentiation trough both PKC and tyrosine phosphorylation cascades. Exp Cell Res 222: 61-69, 1996.
11. 3 activates raf kinase and raf perinuclear translocation via a protein kinase C-dependent pathway. J Biol Chem 268: 25132-25138, 1993.
12. 3 stimulated Egr induction. J Biol Chem 270: 3642-3647, 1995.
13. 3 induced activation and subsequent nuclear translocation of MAPK is upstream regulated by PKC in HL-60 cells. Bioch Biophys Res Com 241: 419-426, 1997.
14. 3. Biochem J 289: 675-679, 1993.
15. Berridge MJ: Inositol triphosphate and calcium signalling. Nature 361: 315-325, 1993.
16. Ward SG, June CH and Olive D: PI3-kinase: a pivotal pathway in T-cell activation? Immunology Today 17: 187-197, 1996.
17. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R and Soltoff S: Oncogenes and signal transduction. Cell 64: 281-302, 1991.
18. Kapeller R and Cantley L: Phosphatidylinositol 3-kinase. BioEssays 16: 1071-1080, 1994.
19. Kimura K, Hattori S, Kabuyama Y, Shizawa Y, Takayanagi J, Nakamura S, Toki S, Matsuda Y, Onodera K and Fukui Y: Neurite outgrowth of PC12 cells is supressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J Biol Chem 269: 18961-18967, 1994.
20. Kauffmann-Zeh A, Rodriguez-Vinciana P, Ulrich E, Gilbert C, Coffer P, Downward J and Evan G: Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 385: 544-548, 1997.
21. Kaliman P, Viñals F, Testar X, Palacin M and Zorzano A: Phosphatidylinositol 3-kinase inhibitors block differentiation of sceletal muscle cells. J Biol Chem 271: 19146-19151, 1996.
22. Ptasznik A, Beattie GM, Mally MI, Cirulli V, Lopez A and Hayek A: Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation. J Cell Biol 137: 1127-1136, 1997.
23. Powis GR, Bonjouklian MM, Berggren A, Gallegos R, Abraham C, Ashendel L, Zalkow WF, Matter J, Dodge G, Gridey G and Vlahos CJ: Wortmannin a potent and selective inhibitor of phosphatidylinositol 3-kinase. Cancer Res 54: 2419-2423, 1994.
24. Vlahos CJ, Matter WF, Hui KY and Brown RF: A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269: 5241-5248, 1994.
25. Brun GJ, Williams J, Sabers C, Wiederrecht G, Lawrence JC Jr and Abraham RT: Direct inhibition of the signalling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002. EMBO J 15: 5256-5267, 1996.
26. Lo SK, Van Seventer GA, Levin SM and Wright SD: Two leukocyte receptors (CD11a/CD18 and CD11b/CD18) mediate transient adhesion to endothelium by binding to different ligands. J Immunol 143: 3325-3329, 1989.
27. Wright SD, Tobias PS, Ulevitch RJ and Ramos RA: Lipopolysaccharide (LPS) binding protein opsonizes LPS-hearing particles. J Exp Me 170: 1231-41, 1989.
28. 3. In press, J Steroid Bioch Mol Biol.
29. Chung J, Kuo CJ, Crabtree GR and Blenis J: Rapamycin-FKBP specifically blocks growth-dependent activation of and signalling by the 70 kD and S6 protein kinases. Cell 69: 1227-1236, 1992.
30. 2+-ATPase. Proc Natl Acad Sci USA 87: 2466-2470, 1990.
31. Greber U and Gerace L: Depletion of calcium from the lumen of endoplasmic reticulum reversibly inhibits passive diffusion and signal-mediated transport into the nucleus. J Cell Biol 128: 5-14, 1995.
32. Kutner A, Perlman LK, Lago A, Sicinski RR, Schnoes HK, DeLuca HF: Novel convergent synthesis of side-chain modified analogues of 1α,25-dihydroxycholecalciferol and 1α,25-dihydroxyergocalciferol. J Org Chem 53: 3450-57, 1988.
33. Busca R, Bertolotto C, Ortonne J-P and Ballotti R: Inhibition of the phosphatidylinositol 3-kinase/p70S6-kinase pathway induces melanoma cell differentiation. J Biol Chem 271: 31824-31830, 1996.
34. Khoo S and Cobb MH: Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion. Proc Natl Acad Sci USA 94: 5599-5604, 1997.