Effects of mexiletine on ATP sensitive K+ channel of rat skeletal muscle fibres: A state dependent mechanism of action

British Journal of Pharmacology

Volumn 125, Issue 4, 1998, Pages 858-864

  Tricarico, Domenico ^a   Barbieri, Mariagrazia ^a   Franchini, Carlo ^a   Tortorella, Vincenzo ^a   Conte Camerino, Diana ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

ADP; ATP sensitive K+ channel; Mexiletine; Skeletal muscle fibres; UDP

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIARRHYTHMIC AGENT; MEXILETINE; NUCLEOSIDE; POTASSIUM CHANNEL; PYROPHOSPHATE; URIDINE DIPHOSPHATE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; MALE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; ANIMALS; BINDING SITES; MALE; MEMBRANE POTENTIALS; MEXILETINE; MUSCLE, SKELETAL; NUCLEOSIDES; POTASSIUM CHANNELS; RATS; RATS, WISTAR; TIME FACTORS; URIDINE DIPHOSPHATE;

EID: 0031758608     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702117     Document Type: Article

References (36)

1. ALLARD, B. & LAZDUNSKI, M. (1992). Nucleotide diphosphates activate the ATP-sensitive potassium channel in mouse skeletal muscle. Pflügers Arch., 422, 185-192.
2. ATP channels of mammalian skeletal muscle. J. Membr. Biol., 152, 111-116.
3. BODEWEI, R., HEHL, S. & NEUMCKE, B. (1992). The cardiotonic bipyridine AWD 122-60 inhibits adenosine triphosphate-sensitive potassium channels of mouse skeletal muscle. Naunyn-Schmiedeberg's Arch. Pharmacol., 345, 570-577.
4. + channels toward sulfonylureas. Circ. Res., 82, 272-278.
5. CANNON, S.C. (1996). Ion-channel defects and aberrant excitability in myotonia and periodic paralysis. TINS, 19, 3-10.
6. ATP channel subunits. Neuron, 18, 827-838.
7. DAVIES, N.W., STANDEN, N.B. & STANFIELD, P.R. (1991). ATP-dependent potassium channels of muscle cells: their properties, regulation, and possible functions. J. Bioenerg. Biomemb., 23, 509-533.
8. DE LUCA, A., NATUZZI, F., LENTINI, G., FRANCHINI, C., TORTORELLA, V. & CONTE CAMERINO, D. (1995). Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers. Naunyn-Schmiedeberg's Arch. Pharmacol., 352, 653-661.
9. DE LUCA, A., PIERNO, S., NATUZZI, F., FRANCHINI, C., DURANTI, A., LENTINI, G., TORTORELLA, V., JOCKUSCH, H. & CONTE CAMERINO, D. (1997). Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on abnormal excitability of the myotonic ADR mouse. J. Pharmacol. Exp. Ther., 282, 93-100.
10. + channels in cardiac muscle by the sulphonylurea drug glibenclamide. J. Pharmacol. Exp. Ther., 261, 540-545.
11. + channel by MgATP complexes in guinea-pig ventricular myocytes. J. Physiol., 479, 95-107.
12. HEHL, S. & NEUMCKE, B. (1993). Negative cooperativity may explain flat concentration-response curves of ATP-sensitive potassium channels. Eur. Biophys. J., 22, 1-4.
13. HISANAGA, K., ONODERA, H. & KOGURE, K. (1986). Changes in levels of purine and pyrimidine nucleotides during acute hypoxia and recovery in neonatal rat brain. J. Neurochem., 47, 1344-1350.
14. KATP: an inward rectifier subunit plus the sulfonylurea receptor. Science, 270, 1166-1170.
15. INAGAKI, N., TSUURA, Y., NAMBA, N., MASUDA, K., GONOI, T., HORIE, M., SEINO, Y., MIZUTA, M. & SEINO, S. (1995b). Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and hearth. J. Biol. Chem., 270, 5691-5694.
16. JACKSON, C.E., BAROHN, R.J. & PTACEK, L.J. (1994). Paramyotonia congenita: abnormal short exercise test, and improvement after mexiletine therapy. Muscle & Nerve, 17, 763-768.
17. ATP channels: operative state-dependent regulation by a nucleotide diphosphate. Pflügers Archiv., 431, 800-802.
18. LEHMANN-HORN, F., ENGEL, A.G., RICKER, K. & RÜDEL, R. (1994). The Periodic Paralyses and Paramyotonia Congenita, in Myology 2ed Engel A.G. and Franzini-Armstrong C. (eds). 50, 1303-1327.
19. LEHMANN-HORN, F. & RÜDEL, R. (1996). Molecular pathophysiology of voltage-gated ion channels. Rev. Physiol. Biochem. Pharmacol., 128, 195-268.
20. MORTENSEN, E., YANG, T. & REFSUM, H. (1993). Potassium channel blockade as an antiarrhythmic principle. Cardiovasc. Drug. Rev., 11, 370-381.
21. + channels of mouse skeletal muscle by disopyramide. Eur. J. Pharmacol., 284, 35-41.
22. + channels in the nodal membrane of frog nerve by holding potential and tetrodotoxin. Biochim. Biophys. Acta. 727, 177-184.
23. NICHOLS, C.G. & LEDERER, W.J. (1991). Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am. J. Physiol., 261, H1675-H1686.
24. NICHOLS, C.G., SHYNG, S.L., NESTOROWICZ, A., GASLER, B., CLEMENT, IV, J.P., GONZALES, G., AGUILAR-BRYAN, L., PERMUTT, M.A. & BRYAN, J. (1996). Adenosine diphosphate as an intracellular regulator of insulin secretion. Science, 272, 1785-1787.
25. OLSCHEWSKI, A., BRAU, M.E., OLSCHEWSKI, H., HEMPELMANN, G. & VOGEL, W. (1996). ATP-dependent potassium channel in rat cardiomyocytes is blocked by lidocaine. Circulation, 93, 656-659.
26. ATP channels is mediated by Kir6.2. Proc. Natl. Acad. Sci. USA. 94, 11716-11720.
27. SAKMANN, B. & NEHER, E. (1983). Geometric parameters of pipettes and membrane patches, in Single-Channel Recording B. Sakmann and E. Neher, (eds). Plenum, New York, 37-51.
28. + channels. Br. J. Pharmacol., 115, 381-382.
29. + channel-opening drugs. Am. J. Physiol., 269, C525-C545.
30. + channels of skeletal muscle fibers from young adult and aged rats: possible involvement of thiol-dependent redox mechanisms in the age-dependent modifications of their biophysical and pharmacological properties. Mol. Pharmacol., 46, 754-761.
31. ATP channel complex of rat skeletal muscle. Eur. J. Pharmacol., 321, 369-378.
32. + depleted rat, an animal model of hypokalemic periodic paralysis. Mol. Pharmacol., 54, 197-206.
33. WELSH, D.G. & LINDINGER, M.I. (1997). Metabolite accumulation increases adenine nucleotide degradation and decreases glycogenolysis in ischaemic rat skeletal muscle. Acta Physiol. Scand., 161, 203-210.
34. WU, B., SATO, T., KIYOSUE, T. & ARITA, M. (1992). Blockade of 2,4-dinitrophenol induced ATP sensitive potassium current in guinea pig ventricular myocytes by class I antiarrhythmic drugs. Cardiovasc. Res., 26, 1095-1011.
35. + channels in Xenopus oocytes. Eur. J. Pharmacol., 247, 267-272.
36. + channels from pancreatic B-cells. FEBS Lett., 239, 241-244.