The effects of norepinephrine on myocardial biology: Implications for the therapy of heart failure

Clinical Cardiology

Volumn 21, Issue 12 SUPPL. 1, 1998, Pages

  Colucci, Wilson S ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Norepinephrine; Remodeling

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; NORADRENALIN;

APOPTOSIS; BETA ADRENERGIC STIMULATION; CARDIOVASCULAR FUNCTION; CONFERENCE PAPER; DRUG EFFECT; EXTRACELLULAR MATRIX; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE REMODELING; HUMAN; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SYMPATHETIC TONE;

EID: 0031757052     PISSN: 01609289     EISSN: None     Source Type: Journal    
DOI: 10.1002/clc.4960211305     Document Type: Conference Paper

References (42)

1. Chidsey CA, Braunwald E: Sympathetic activity and neurotransmitter depletion in congestive heart failure. Pharmacol Rev 1966; 18:685-700
2. Thomas JA, Marks BH: Plasma norepinephrine in congestive heart failure. Am J Cardiol 1978;41:233-243
3. Levine TB, Francis GS, Goldsmith SR, Simon AB, Cohn JN: Activity of the sympathetic nervous system and renin angiotensin system assessed by plasma hormone levels and their relation to hemodynamic abnormalities in congestive heart failure. Am J Cardiol 1982;49:1659-1666
4. Leimbach, JR, Wallin BG, Victor RG, Aylward PE, Sundlof G, Mark AL: Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure. Circulation 1986;73:913-919
5. Swedberg K, Viquerat C, Rouleau JL, Roizen M, Atherton B, Parmley WW, Chatterjee K: Comparison of myocardial catecholamine balance in chronic congestive heart failure and angina pectoris without failure. J Clin Pharmacol 1984;54:783-786
6. Hasking GJ, Esier MD, Jennings GL, Burton D, Johns JA, Korner PI: Norepinephrine spillover to plasma in patients with congestive heart failure: Evidence of increased overall and cardiorenal sympathetic nervous activity. Circulation 1986;73:615-621
7. Esler M, Kaye D, Lambert G, Esler D, Jennings G: Adrenergic nervous system in heart failure. Am J Cardiol 1997;80(11A):7L-14L
8. Francis GS, Benedict C, Johnstone DE, Kirlin PC, Nicklas J, Liang CS, Kubo SH, Rudin-Toretsky E, Yusuf S: Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD). Circulation 1990;82(5): 1724-1729
9. Rundqvist B, Elam M, Bergmann-Sverrisdottir Y, Eisenhofer G, Friberg P: Increased cardiac adrenergic drive precedes generalized sympathetic activation in human heart failure. Circulation 1997; 95(1):169-175
10. Cohn JN: Structural basis for heart failure: Ventricular remodeling and its pharmacological inhibition. Circulation 1995; 91(10): 2504-2507
11. Colucci WS: Molecular and cellular mechanisms of myocardial failure. Am J Cardiol 1997;80(11A):15L-25L
12. Simpson P, McGrath A: Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha1 adrenergic response. J Clin Invest 1983;72:732-738
13. 1Aadrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem 1993;268:15374-15380
14. Clark WA, Rudnick SJ, LaPres JJ, Andersen LC, LaPointe MC: Regulation of hypertrophy and atrophy in cultured adult heart cells. Circ Res 1993;73:1163-1176
15. Takahashi T, Allen PD, Izumo S: Expression of A-, B-, and C-type natriuretic peptide genes in failing and developing human ventricles. Circ Res 1992;71:9-17
16. Arai M, Alpert NR, MacLennan DH, Barton P, Periasamy M: Alterations in sarcoplasmic reticulum gene expression in human heart failure. Circ Res 1993; 72:463-469
17. 2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. J Clin Invest 1992; 90:927-935
18. Feldman AM, Ray PE, Silan CM, Mercer JA, Minobe W, Bristow MR: Selective gene expression in failing human heart. Quantification of steady-state levels of messenger RNA in endomyocardial biopsies using the polymerase chain reaction. Circulation 1991; 83:1866-1872
19. Gwathmey JK, Copelas L, MacKinnon R, Schoen FJ, Feldman MD, Grossman W, Morgan JP: Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res 1987:61(1):70-76
20. i in adult rat ventricular myocytes in vitro (abstr). Circulation 1997;96(suppl I):I-629
21. Narula J, Haider N, Virmani R, DiSalvo TG, Kolodgie FD, Hajjar RJ, Schmidt U, Semigran MJ, Dec GW, Khaw B-A: Programmed myocyte death in end-stage heart failure. N Engl J Med 1996;335: 1182-1189
22. Olivetti G, Abbi R, Quaini F, Kajstura J, Cheng W, Nitahara JA, Quaini E, DeLoreto C, Beltrami CA, Krajewski S, Reed JC, Anversa P: Apoptosis in the failing human heart. N Engl J Med 1997; 336:1131-1141
23. Colucci WS: Apoptosis in the heart. N Engl J Med 1996;335: 1224-1226
24. Kajstura J, Cheng W, Reiss K, Clark WA, Sonnenblick EH, Krajewski S, Reed JC, Olivetti G, Anversa P: Apoptotic and necrotic myocyte cell death are independent contributing variables of infarct size in rats. Lab Invest 1996;74:86-107
25. Saraste A, Pulkki K, Kallajoki M, Henriksen K, Parvinen M, Voipio-Pulkki L-M: Apoptosis in human acute myocardial infarction. Circulation 1997;95:320-323
26. Liu Y, Cigola E, Cheng W, Kajstura J, Olivetti G, Hintze TH, Anversa P: Myocyte nuclear mitotic division and programmed myocyte death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs. Lab Invest 1995;73:771-787
27. Cheng W, Li B, Kajstura J, Li P, Wolin MS, Sonnenblick EH, Hintze TH, Olivetti G, Anversa P: Stretch-induced programmed myocyte cell death. J Clin Invest 1995;96:2247-2259
28. Teiger E, Dam T-V, Richard L, Wisnewsky C, Tea B-S, Gaboury L, Tremblay J, Schwartz K, Harnet P: Apoptosis in pressure overload-induced heart hypertrophy in the rat. J Clin Invest 1996;97: 2891-2897
29. Rona G: Catecholamine cardiotoxicity. J Mol Cell Cardiol 1985; 17:291-306
30. Opie LH, Walpoth B, Barsacchi R: Calcium and catecholamines: Relevance to cardiomyopathies and significance in therapeutic strategies. J Mol Cell Cardiol 1985;17:(suppl 2):21-34
31. Singal PK, Kapur N, Dhillon KS, Beamish RE, Dhalla NS: Role of free radicals in catecholamine-induced cardiomyopathy. Can J Physiol Pharmacol 1982;60:1390-1397
32. Mann DL, Kent RL, Parsons B, Cooper G IV: Adrenergic effects on the biology of the adult mammalian cardiocyte. Circulation 1992; 85:790-804
33. Communal C, Singh K, Pimentel DR, Colucci WS: Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. Circulation 1998; 98: (in press)
34. Shizukuda Y, Buttrick PM, Geenen DL, Borzuk AC, Kitsis RN, Sonnenblick EH: Continuous beta-adrenergic stimulation induces apoptosis in rat myocardium (abstr). Circulation 1997;96(suppl I): I-745
35. Iwase M, Uechi M, Vatner DE, Asai K, Shannon RP, Kudej RK, Wagner TE, Wight DC, Patrick TA, Ishikawa Y, Homey CJ, Vatner SF: Cardiomyopathy induced by cardiac Gsa overexpression. Am J Physiol 1997;41:H585-H589
36. Geng YJ, Ishikawa Y, Vatner DE, Wagner TE, Bishop SP, Vatner SF, Homey CJ: Overexpression of Gsa accelerates programmed death (apoptosis) of myocardiocytes in transgenic mice (abstr). Circulation 1996;94(suppl I):I-282
37. Geng Y-J, Homey CJ, Kim S-J, Yamamoto M, Vatner DE, Wagner TE, Vatner SE, Ishikawa Y: Persistent stimulation of β-adrenergic signaling triggers degeneration and apoptosis of cardiac myocytes (abstr). Circulation 1997;96(suppl I):I-116
38. 2-adrenergic receptor. Science 1994;264:582-586
39. Weber KT, Brilla CG: Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system. Circulation 1991;83:1849-1865
40. Conrad CH, Brooks WW, Hayes JA, Sen S, Robinson KG, Bing OHL: Myocardial fibrosis and stiffness with hypertrophy and heart failure in the spontaneously hyertensive rat. Circulation 1995;91: 161-170
41. Calderone A, Takahashi N, Izzo NJ, Thaik CM, Colucci WS: Pressure- and volume-induced left ventricular hypertrophies are associated with distinct myocyte phenotypes and differential induction of peptide growth factor mRNAs. Circulation 1995;92: 2385-2390
42. Boluyt MO, Long X, Eschenhagen T, Mende U, Schmitz W, Crow MT, Lakatta EG: Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart. Am J Physiol 1995;269(2 Pt 2):H638-647