Multicenter, randomized, double-blind comparison of erythromycin estolate versus amoxicillin for the treatment of acute otitis media in children

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 17, Issue 7, 1998, Pages 470-478

  Scholz, H ^a   Noack, R ^a  

^a HELIOS KLINIKUM BERLIN BUCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ERYTHROMYCIN ESTOLATE;

ADVERSE DRUG REACTION; ARTICLE; CHILD; CLINICAL EXAMINATION; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DEMOGRAPHY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; GERMANY; HEARING LOSS; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OTITIS MEDIA; OTORRHEA; OTOSCOPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; RISK FACTOR; STATISTICAL ANALYSIS; TYMPANOMETRY;

EID: 0031754640     PISSN: 09349723     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01691129     Document Type: Article

References (38)

1. Teele DW, Klein JO, Rosner B, and the Greater Boston Otitis Media Study Group: Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study. Journal of Infectious Diseases (1989) 160:83-94
2. Deutsehe Gesellschaft für Pädiatrische Infektiologie: Atemwegsinfektionen. In: Scholz H, Belohradsky BH, Kreth W, Roos R, Stehr K (eds): Handbuch 1997: Infektionen bei Kindern und Jugendlichen. Futuramed, Munich, (1997) pp. 605-627
3. American Academy of Pediatrics: Haemophilus influenzae infections. In: Peter G (ed): 1997 Red book: report of the Committee on Infectious Diseases. American Academy of Pediatrics, Elk Grove Village, IL (1997) pp. 220-230
4. Hoppe JE, Hahn H, Niethammer D: Umfrage bei niedergelassenen Kinderärzten zur Antibiotika-Behandlung bakterieller Infektionen im Kindersalter. 1. Angina tonsillaris, akute Otitis media. Der Kinderarzt (1995) 25:639-643
5. Berman S, Byrns PJ, Bondy J, Smith PJ, Lezotte D: Otitis media-related antibiotic prescribing patterns, outcomes, and expenditures in a pediatric medicaid population. Pediatrics (1997) 100:585-592
6. Ginsburg CM, Eichenwald HF: Erythromycin: a review of its uses in pediatric practice. Journal of Pediatrics (1976) 89:872-884
7. Jenner PN, Tierney HE, Carle WK: A general practice study of a new approach to the use of antibiotics in the treatment of acute otitis media in children aged three and over. British Journal of Clinical Practice (1987) 41:820-826
8. Institut für Medizinische Statistik: Verschreibungsindex für Pharmazeutika, Deutschland-West, IV. Quartal 1995. IMS GmbH. Institut für Medizinische Statistik, Frankfurt/Main, Germany (1996) p. 301
9. Potthast H, Schug B, Elze M, Schwerdtle R, Blume H: Comparison of bioavailabilities of erythromycin estolate and erythromycin ethylsuccinate suspensions after oral multiple-dose administration. Pharmazie (1995) 50:56-60
10. Croteau D, Bergeron MG, LeBel M: Pharmacokinetic advantages of erythromycin-estolate over ethylsuccinate as determined by high-pressure liquid chromatography. Antimicrobial Agents and Chemotherapy (1988) 32:561-565
11. Hoppe JE, and the Erythromycin Study Group: Comparison of erythromycin estolate and erythromycin ethylsuccinate for treatment of pertussis. Pediatric Infectious Disease Journal (1992) 11:189-193
12. Adam D, Scholz H, and the Pharyngitis Study Group: Five days of erythromycin estolate versus ten days of penicillin V in the treatment of group A streptococcal tonsillopharyngitis in children. European Journal of Clinical Microbiology & Infectious Diseases (1996) 15:712-717
13. Ginsburg CM, McCracken GH, Steinberg JB, Crow SD, Dildy BF, Lancaster K, Olsen K: Management of group A streptococcal pharyngitis: a randomized controlled study of twice-daily erythromycin ethylsuccinate versus crythromycin estolate. Pediatric Infectious Disease Journal (1982) 1:384-387
14. Valtonen M, Piippo T, Pitkäjärvi T, Pyykönen M-L: Comparison of amoxicillin given two and three times a day in acute respiratory infections in children. Scandinavian Journal of Primary Health Care (1986) 4:201-204
15. Principi N, Marchiso P, Bigalli L, Massironi E: Amoxicillin twice daily in the treatment of acute otitis media in infants and children. European Journal of Pediatrics (1986) 145:522-525
16. Chow AW, Hall CB, Klein JO, Kammer RB, Meyer RD, Remington JS: General guidelines for the evaluation of new anti-infective drugs for the treatment of respiratory tract infections. Clinical Infectious Diseases (1992) 15, Supplement 1:62-88
17. Jerger J: Clinical experience with impedance audiometry. Archives of Otolaryngology (1970) 92:311-324
18. Dunnett CW, Gent M: Significance testing to establish equivalence between treatments, with special reference to data in the form of 2 × 2 tables. Biometrics (1977) 33:593-602
19. McLinn SE, McCarty JM, Perrotta R, Pichichero ME, Reidenberg BE, and members of the Ceftibuten Otitis Media United States Study Group: Multicenter controlled trial comparing ceftibuten with amoxicillin/elavulanate in the empiric treatment of acute otitis media. Pediatric Infectious Disease Journal (1995) 14, Supplement: 108-114
20. McLinn SE: A multicenter, double blind comparison of azithromycin and amoxicillin/clavulanate for the treatment of acute otitis media in children. Pediatric Infectious Disease Journal (1996) 15, Supplement: 20-23
21. H) for treatment of acute otitis media in children. Pediatric Infectious Disease Journal (1997) 16:463-170
22. Odio CM, Kusmiesz H, Shelton S, Nelson JD: Comparative treatment trial of Augmentin versus cefactor for acute otitis media with effusion. Pediatrics (1985) 75:819-826
23. Hoberman A, Paradise JL, Block S, Burch DJ, Jacobs MR, Balanescu MI: Efficacy of amoxicillin/clavulanale for acute otitis media: relation to Streptococcus pneumoniae susceptibility. Pediatric Infectious Disease Journal (1996) 15:955-962
24. Carlin SA, Marchant CD, Shurin PA, Johnson CE, Super DM, Rehmus JM: Host factors and early therapeutic response in acute otitis media. Journal of Pediatrics (1991) 118:178-183
25. Berman S, Roark R: Factors influencing outcome in children treated with antibiotics for acute otitis media. Pediatric Infectious Disease Journal (1993) 12:20-24
26. Kaleida PH, Casselbrant ML, Rockette HE, Paradise JL, Bluestone CD, Blatter MM, Reisinger KS, Wald ER, Supance JS: Amoxicillin or myringotomy or both for acute otitis media: results of a randomised clinical trial. Pediatrics (1991) 87:466-474
27. Chan KH, Bluestone CD, Tan LS, Reisinger KS, Blatter MM, Fall PA: Comparative study of sultamicillin and amoxicillin-clavulanate: treatment of acute otitis media. Pediatric Infectious Disease Journal (1993) 12:24-28
28. Pelton SI, Teele DW, Shurin PA, Klein JO: Disparate cultures of middle ear fluids. Results from children with bilateral otitis media. American Journal of Diseases of Children (1980) 134:951-953
29. Bergeron MG, Ahronheim G, Richard JE, Riding K, Cron C, Bryer D, MacDonald N, Bouchard M, Young J, Dempsey EE: Comparative efficacies of erythromycin-sulfisoxazole and cefactor in acute otitis media: a double blind randomised trial. Pediatric Infectious Disease Journal (1987) 6:654-660
30. Brook I, Yocum P: Bacteriology and beta-lactamase activity in ear aspirates of acute otitis media that failed amoxicillin therapy. Pediatric Infectious Disease Journal (1995) 14:805-808
31. Pichichero ME, McLinn S, Aronovitz G, Fiddes R, Blumer J, Nelson K, Dashefsky B: Cefprozil treatment of persistent and recurrent acute otitis media. Pediatric Infectious Disease Journal (1997) 16:471-478
32. Doern GV, Brueggemann AB, Pierce G, Holley HP, Rauch A: Antibiotic resistance among clinical isolates of Haemophilus influenzae in the United States in 1994 and 1995 and detection of β-lactamase-positive strains resistant to amoxicillin-clavulanate: results of a national multicenter surveillance study. Antimicrobial Agents and Chemotherapy (1997) 41:292-297
33. Cullmann W, Hagedorn J, Heinzmann W, Ringelmann R, Tauchnitz R, Wiedemann B: Multizentrische Evaluierung oraler Antibiotika. Resistenzverhalten in verschiedenen deutschen Zentren. Chemotherapie Journal (1993) 2:95-100
34. Kayser FH, Morenzoni G, Santanam P: The second European collaborative study on the frequency of antimicrobial resistance in Haemophilus influenzae. European Journal of Clinical Microbiology & Infectious Diseases (1990) 9:810-817
35. Bass JW, Steele RW, Wiebe RA, Dierdorff EP: Erythromycin concentrations in middle ear exudates. Pediatrics (1971) 48:417-422
36. Howie VM, Ploussard JH: The "in vivo sensitivity test" - bacteriology of middle ear exudate. Pediatrics (1969) 44:940-944
37. Howie VM, Ploussard JH: Efficacy of fixed combination antibiotics versus separate components in otitis media. Clinical Pediatrics (1972) 11:205-214
38. Urquhart J: Ascertaining how much compliance is enough with outpatient antibiotic regimens. Postgraduate Medical Journal (1992) 68, Supplement 3:49-58